Results 181 to 190 of about 49,554 (304)

Identification of Crucial Drug Targets and Pathways to Reprogram Drug Resistance Through Epigenetic Modulation in Advanced Lung Cancer Using Integrated Bioinformatics Approach

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Resistance to chemotherapy, which is demonstrated in almost every patient with advanced‐stage lung cancer (ALC), underscores an urgent need to unravel the underlying molecular mechanisms and identify novel strategies to overcome drug resistance. In the present study, an attempt was made to identify epigenetic targets and modulators that can be
Okibur Rahman, Mossammat Rima Akter, Nur Alam   +2 more
wiley   +1 more source

Characterization and Validation of Antibodies for Immunohistochemical Staining of the Chemokine CXCL12. [PDF]

J Histochem Cytochem, 2019
Fricker SP, Sprott K, Spyra M, Uhlig P, Lange N, David K, Wang Y.   +6 more
europepmc   +1 more source

Supplementary Figure 6 from The CXCL12–CXCR4 Chemokine Pathway: A Novel Axis Regulates Lymphangiogenesis

, 2023
Zhuo Wei, Lin Jia, Nan Song, Xin‐an Lu, Yanping Ding, Xiaofeng Wang, Xiaomin Song, Yan Fu, Yongzhang Luo   +8 more
openalex   +1 more source

Supplementary Figure 2 from The CXCL12–CXCR4 Chemokine Pathway: A Novel Axis Regulates Lymphangiogenesis [PDF]

, 2023
Zhuo Wei, Lin Jia, Nan Song, Xin‐an Lu, Yanping Ding, Xiaofeng Wang, Xiaomin Song, Yan Fu, Yongzhang Luo   +8 more
openalex   +1 more source

C‐X‐C chemokine receptor CXCR4 mediates diurnal changes in the aggregation and dispersion of CD8+ T cells within the tumor microenvironment

International Journal of Cancer, Volume 158, Issue 6, Page 1740-1754, 15 March 2026.
What's new? In addition to governing daily variations in biological activity, the circadian clock regulates immune cell migration into tumors. Whether this influence extends to immune cell localization within the tumor microenvironment (TME) is unknown. Here, using cell and animal models, the authors investigated immune cell distribution within the TME
Akito Tsuruta, Marina Fujimoto, Yasuha Hiraoka, Aoi Taniguchi, Yuki Shiiba, Takuto Inoki, Tomoaki Yamauchi, Yuya Yoshida, Naoya Matsunaga, Shigehiro Ohdo, Satoru Koyanagi   +10 more
wiley   +1 more source

Identification of an inhibitory chemokine for the CXCL12/CXCR4 axis that affects stem cell homeostasis

, 2014
Takahiko Hara, Kosuke Tanegashima
openalex   +2 more sources

The Study of CXCL7-CXCL12 Chemokine Heterodimer by NMR Spectroscopy [PDF]

, 2013
Sushant Patil, Irina V. Nesmelova
openalex   +1 more source

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, Volume 46, Issue 2, Page 352-381, March 2026.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

Local Anesthetics in Cancer: Mechanisms and Translational Perspectives

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Local anesthetics demonstrate multifaceted antitumor effects that collectively contribute to cancer suppression. Beyond canonical sodium channel blockade, these agents exert the following pharmacological actions: inhibition of tumor cell proliferation, suppression of migration and invasion, induction of proapoptotic pathways, attenuation of ...
Wan‐li Wang, Tu Huang, Yi‐hang Hao, Min Zheng, Xin‐hua Liang   +4 more
wiley   +1 more source

CXCL12 chemokine dimer signaling modulates acute myelogenous leukemia cell migration through altered receptor internalization [PDF]

Donovan Drouillard, Michael Halyko, Elizabeth Cinquegrani, Maria Poimenidou, Miracle Emosivbe, Donna McAllister, Francis C. Peterson, Adriano Marchese, Michael B. Dwinell   +8 more
openalex   +1 more source