Spatio-temporal regulation of concurrent developmental processes by generic signaling downstream of chemokine receptors [PDF]
eLife, 2018 Chemokines are secreted proteins that regulate a range of processes in eukaryotic organisms. Interestingly, different chemokine receptors control distinct biological processes, and the same receptor can direct different cellular responses, but the basis ...
Divyanshu Malhotra +3 more
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PET Imaging Radiotracers of Chemokine Receptors [PDF]
Molecules, 2021 Chemokines and chemokine receptors have been recognized as critical signal components that maintain the physiological functions of various cells, particularly the immune cells.
Santosh R. Alluri +2 more
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Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3 [PDF]
Cell Discovery, 2022 Chemokine receptors are a family of G-protein-coupled receptors with key roles in leukocyte migration and inflammatory responses. Here, we present cryo-electron microscopy structures of two human CC chemokine receptor–G-protein complexes: CCR2 bound to ...
Zhehua Shao +21 more
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Differential expression of chemokine receptors on monocytes in TB and HIV S [PDF]
Heliyon, 2023 In the present study, we defined multiple chemokine receptors expressed by classical, intermediate and non-classical monocyte subsets in TB, HIV and TB/HIV co-infection and associate it with the perturbation of monocyte subsets due to the diseases ...
Wegene Tamene +7 more
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CC chemokine receptors are prognostic indicators of gastric cancer and are associated with immune infiltration [PDF]
BMC Medical GenomicsBackground CC chemokine receptors are responsible for regulating the tumor microenvironment (TME) and participating in carcinogenesis and tumor advancement.
Xinghe Liao +4 more
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Closely related, yet unique: Distinct homo- and heterodimerization patterns of G protein coupled chemokine receptors and their fine-tuning by cholesterol. [PDF]
PLoS Computational Biology, 2018 Chemokine receptors, a subclass of G protein coupled receptors (GPCRs), play essential roles in the human immune system, they are involved in cancer metastasis as well as in HIV-infection.
Stefan Gahbauer +2 more
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Bidirectional Regulation of Opioid and Chemokine Function
Frontiers in Immunology, 2020 The opioid family of GPCRs consists of the classical opioid receptors, designated μ-, κ-, and δ-opioid receptors, and the orphanin-FQ receptor, and these proteins are expressed on both neuronal and hematopoietic cells.
Thomas J. Rogers
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Chemokines and chemokine receptors: A new strategy for breast cancer therapy
Cancer Medicine, 2020 Chemokines and chemokine receptors not only participate in the development of tissue differentiation, hematopoiesis, inflammation, and immune regulation but also play an important role in the process of tumor development.
Hui Liu +8 more
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Human Mas-related G protein-coupled receptors-X1 induce chemokine receptor 2 expression in rat dorsal root ganglia neurons and release of chemokine ligand 2 from the human LAD-2 mast cell line [PDF]
, 2013 Primate-specific Mas-related G protein-coupled receptors-X1 (MRGPR-X1) are highly enriched in dorsal root ganglia (DRG) neurons and induce acute pain. Herein, we analyzed effects of MRGPR-X1 on serum response factors (SRF) or nuclear factors of activated
A Breit +73 more
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Chemokine Receptors and Phagocyte Biology in Zebrafish
Frontiers in Immunology, 2020 Phagocytes are highly motile immune cells that ingest and clear microbial invaders, harmful substances, and dying cells. Their function is critically dependent on the expression of chemokine receptors, a class of G-protein-coupled receptors (GPCRs ...
Frida Sommer +2 more
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