Results 31 to 40 of about 279,214 (183)

Prospects for targeting ACKR1 in cancer and other diseases

Frontiers in Immunology, 2023
The chemokine network is comprised of a family of signal proteins that encode messages for cells displaying chemokine G-protein coupled receptors (GPCRs).
Kyler S. Crawford, Brian F. Volkman
doaj   +1 more source

Pathophysiology of chemokines and chemokine receptors in dermatological science: A focus on psoriasis and cutaneous T-cell lymphoma

Dermatologica Sinica, 2012
Skin is an immunological organ with a delicate immunological network that governs the homeostasis and homing of the pro- and anti-inflammatory immune cells.
Chih-Hung Lee, Sam Tzen-Yue Hwang
doaj   +1 more source

The role of CXCR3 and its ligands in cancer

Frontiers in Oncology, 2022
Chemokines are a class of small cytokines or signaling proteins that are secreted by cells. Owing to their ability to induce directional chemotaxis of nearby responding cells, they are called chemotactic cytokines. Chemokines and chemokine receptors have
Xiaoming Wang, Yangyang Zhang, Sen Wang, Hongyan Ni, Peng Zhao, Guangyu Chen, Benling Xu, Long Yuan   +7 more
doaj   +1 more source

Mathematical Model of HIV superinfection dynamics and R5 to X4 switch [PDF]

, 2006
During the HIV infection several quasispecies of the virus arise, which are able to use different coreceptors, in particular the CCR5 and CXCR4 coreceptors (R5 and X4 phenotypes, respectively).
Bagnoli, Franco, Lio, Pietro, Sguanci, Luca   +2 more
core   +1 more source

Evolution of chemokine receptors is driven by mutations in the sodium binding site.

PLoS Computational Biology, 2018
Chemokines and their receptors (members of the GPCR super-family) are involved in a wide variety of physiological processes and diseases; thus, understanding the specificity of the chemokine receptor family could help develop new receptor specific drugs.
Bruck Taddese, Madeline Deniaud, Antoine Garnier, Asma Tiss, Hajer Guissouma, Hervé Abdi, Daniel Henrion, Marie Chabbert   +7 more
doaj   +1 more source

The Effect of N-Terminal Cyclization on the Function of the HIV Entry Inhibitor 5P12-RANTES. [PDF]

, 2017
Despite effective treatment for those living with Human Immunodeficiency Virus (HIV), there are still two million new infections each year. Protein-based HIV entry inhibitors, being highly effective and specific, could be used to protect people from ...
F Nguyen, Anna, J LiWang, Patricia, Jian, Mike, S Schill, Megan   +3 more
core   +2 more sources

CXCR2 deficient mice display macrophage-dependent exaggerated acute inflammatory responses [PDF]

, 2017
CXCR2 is an essential regulator of neutrophil recruitment to inflamed and damaged sites and plays prominent roles in inflammatory pathologies and cancer. It has therefore been highlighted as an important therapeutic target.
A Mantovani, A Rot, A Rot, A Zlotnik, A Zlotnik, AA Filardy, AE Cardona, AEI Proudfoot, C Schinke, D Marvel, DI Gabrilovich, F Bachelerie, F Balkwill, F Porcheray, F Sallusto, FR Balkwill, G Cacalano, H Saiwai, HM Baldwin, J Dalli, J Schindelin, J Yang, J-I Youn, J-I Youn, K Kishida, KM Hertzer, L Liu, M-C Lo, MK Ho, O Soehnlein, P Ranganathan, P Scapini, RA Navarro-Xavier, RM Devalaraja, S Milatovic, T Jamieson, T Jamieson, T Kakinuma, TJ Schall   +38 more
core   +1 more source

Chemokines and chemokine receptors: an overview

Frontiers in Bioscience, 2009
Chemokines are chemotactic cytokines orchestrating leukocyte recruitment in physiological and pathological conditions. This complex system includes 42 molecules and 19 receptors and is subjected to different levels of regulation, including ligand production, post-translational modifications and degradation, as well as receptor expression and signaling ...
R. Bonecchi, E.R. Galliera, E.M. Borroni, M.M. Corsi, M. Locati, A. Mantovani   +5 more
openaire   +3 more sources

The bovine chemokine receptors and their mRNA abundance in mononuclear phagocytes

BMC Genomics, 2010
Background The chemokine and chemokine receptor families play critical roles in both the healthy and diseased organism mediating the migration of cells.
Ashley George, Lawrence Freya, Easton Victoria, Siddiqui Nazneen, Widdison Stephanie, Werling Dirk, Watson Michael, Coffey Tracey J   +7 more
doaj   +1 more source

Chemokines, molecular drivers of thromboinflammation and immunothrombosis

Frontiers in Immunology, 2023
Blood clotting is a finely regulated process that is essential for hemostasis. However, when dysregulated or spontaneous, it promotes thrombotic disorders.
Julian Leberzammer, Julian Leberzammer, Julian Leberzammer, Philipp von Hundelshausen, Philipp von Hundelshausen   +4 more
doaj   +1 more source