Results 81 to 90 of about 24,401 (257)

Serum cholesterol acceptor capacity in intrauterine growth restricted fetuses [PDF]

, 2017
AIM Intrauterine growth restriction (IUGR) is an independent risk factor for the development of cardiovascular diseases later in life. The mechanisms whereby slowed intrauterine growth confers vascular risk are not clearly established.
Mohaupt, Markus G, Ulrich Pecks, Escher, Geneviève, Bauerschlag, Dirk O., Mohaupt, Markus G., Pecks, Ulrich, Maass, Nicolai, Nicolai Maass, Orlikowsky, Thorsten, Bauerschlag, Dirk O, Rath, Werner, Markus G. Mohaupt, Werner Rath, Thorsten Orlikowsky, Geneviève Escher, Dirk O. Bauerschlag   +15 more
core   +1 more source

Photodynamic Priming and Minocycline Overcome Chemoresistance by Reprogramming the Pancreatic Tumor Immune Microenvironment In Vivo

Advanced Science, EarlyView.
Dual priming with minocycline and photodynamic priming reprograms the pancreatic tumor microenvironment to overcome chemoresistance. By suppressing DNA repair enzyme Tdp1, inducing photooxidative damage, and enhancing irinotecan delivery via light‐activated nanoencapsulation, this strategy remodels the tumor microenvironment and drives immune ...
Fernanda V. Cabral, Jose Quilez‐Alburquerque, Olivia Mooradian, Shivendran Vytheswarran, Badri Parshad, Girgis Obaid, Huang‐Chiao Huang, Tayyaba Hasan   +7 more
wiley   +1 more source

Effects of smoking cessation on HDL functionality

Tobacco Induced Diseases, 2019
Objective Cigarette smoking is positively correlated with the morbidity of cardiovascular diseases (CVD). It was reported that reduced high density lipoprotein (HDL) functionality is one of the causes of CVD.
Emi Kawachi, Kohei Takata, Satoshi Imaizumi, Shin-ichiro Miura, Keijiro Saku   +4 more
doaj   +1 more source

Intestinal Source Control of Lipid Metabolism by Enzyme‐Probiotic Encapsulated, Spatiotemporal Crosslinked, and Small Intestine‐Adhesive Hydrogel Microspheres

Advanced Science, EarlyView.
A thiol‐modified alginate hydrogel microsphere‐encapsulated enzyme‐probiotic biohybrid (AKK‐COD) system has been developed to address the spatiotemporal delivery and colonization challenges of small intestine‐targeted probiotic for lipid metabolism regulation. The system exerts sequential functions of intragastric protection, small intestinal adhesion,
Xiaolin Wu, Weiwen Liang, Siqi He, Guangyuan Chen, Hui Zhou, Xinglong Wang, Yifei Li, Dingcai Wu, Bingna Zheng, Ruoxu Dou, Rongkang Huang   +10 more
wiley   +1 more source

Characterization and response to exercise training of HDL-specific phospholipid efflux

Journal of Lipid Research
The HDL-specific phospholipid efflux (HDL-SPE) assay is a novel cell-free measure of HDL function that is inversely associated with coronary artery disease. However, the effect of exercise training on HDL-SPE is unknown.
Eric C. Leszczynski, Charles S. Schwartz, Kiani J.C. Jacobs, Prasun K. Dev, Sujoy Ghosh, Jeremy M. Robbins, Robert E. Gerszten, Anand Rohatgi, Timothy S. Collier, Robert J. Konrad, Masaki Sato, Rafael Zubirán, Claude Bouchard, Edward B. Neufeld, Alan T. Remaley, Mark A. Sarzynski   +15 more
doaj   +1 more source

Dalcetrapib and anacetrapib differently impact HDL structure and function in rabbits and monkeys

Journal of Lipid Research, 2017
Inhibition of cholesteryl ester transfer protein (CETP) increases HDL cholesterol (HDL-C) levels. However, the circulating CETP level varies and the impact of its inhibition in species with high CETP levels on HDL structure and function remains poorly ...
Mathieu R. Brodeur, David Rhainds, Daniel Charpentier, Teodora Mihalache-Avram, Mélanie Mecteau, Geneviève Brand, Evelyne Chaput, Anne Perez, Eric J. Niesor, Eric Rhéaume, Cyrille Maugeais, Jean-Claude Tardif   +11 more
doaj   +1 more source

In Vivo Inflammation Does Not Impair ABCA1-Mediated Cholesterol Efflux Capacity of HDL

, 2012
HDL provides atheroprotection by facilitating cholesterol efflex from lipid-laden macrophages in the vessel wall. In vitro studies have suggested impaired efflux capacity of HDL following inflammatory changes.
Wolfkamp, Simone C. S., Dallinga-Thie, Geesje M., Franssen, Remco, Schimmel, Alinda W. M., van Leuven, Sander I., Stroes, Erik S. G.   +5 more
core   +1 more source

Biophysical characterization of reactions associated with reverse cholesterol transport [PDF]

, 2012
This thesis aimed at improving our understanding of reactions relevant in the reverse cholesterol transport (RCT). RCT facilitates cholesterol homeostasis and is the most important pathway involved in cardiovascular disease.
Zehender, Fabian
core   +1 more source

T‐Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan‐Cancer Characteristics, and Therapeutic Interventions

Advanced Science, EarlyView.
This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang, Wanhui Dong, Jian Chen, Zhangjie Zhou, Shujuan Fu, Tingting Wu, Haiyan Jiang, Zhiying Wang, Zhixian Zhong, Yi Zhong   +9 more
wiley   +1 more source

Lower than average HDL cholesterol efflux capacity in Lithuanian population [PDF]

Lipids in Health and Disease, 2019
Abstract Background The aim of our study was to evaluate high-density lipoprotein cholesterol (HDL-C) efflux capacity in healthy controls and patients with severe dyslipidemia. Evaluation of HDL function may be beneficial for better understanding of cardiovascular diseases, as well as for taking actions to
Kutkienė, Sandra, Petrulionienė, Žaneta, Karčiauskaitė, Dovilė, Laucevičius, Aleksandras, Matuzevičienė, Gabija, Staigytė, Justina, Šaulytė Mikulskienė, Akvilė, Gargalskaitė, Urtė, Skiauterytė, Eglė, Kovaitė, Milda   +9 more
openaire   +4 more sources