Results 91 to 100 of about 24,401 (257)

Senescent Cell Derived Artificial Vesicle‐Based Senolytic Sonovaccine Platform with Augmented Lymph Node Delivery and Antigen Cross‐Presentation Efficacy

Advanced Science, EarlyView.
A senolytic sonovaccine platform (SenoVac) is developed, in which senescent cell‐derived vesicles serve as broad senescent cell antigen reservior. The “2‐step” click chemistry strategy for effective lymph node delivery, and ultrasound‐triggered endosomal escape to boost cross‐presentation, ensures efficient senescent cell clearance and disease ...
Liang Zhang, Yubo Lai, Jia Wang, Lingling Liu, Jieyuan An, Mi Qu, Yuan Liang, Bijun Tan, Guodong Yang, Xuekang Yang, Lijun Yuan   +10 more
wiley   +1 more source

The LXR agonist T0901317 promotes the reverse cholesterol transport from macrophages by increasing plasma efflux potential

Journal of Lipid Research, 2008
The liver X receptors (LXRs) have been shown to affect lipoprotein plasma profile, lipid metabolism, and reverse cholesterol transport (RCT). In the present study, we investigated whether a short-term administration of the synthetic LXR agonist T0901317 (
Ilaria Zanotti, Francesco Potì, Matteo Pedrelli, Elda Favari, Elsa Moleri, Guido Franceschini, Laura Calabresi, Franco Bernini   +7 more
doaj   +1 more source

Baseline characteristics of participants across increasing quartile of cholesterol efflux capacity–radiolabeled.

, 2021
Baseline characteristics of participants across increasing quartile of cholesterol efflux capacity–radiolabeled.
Parag H. Joshi (11462674), Anand Rohatgi (4917304), Ian J. Neeland (3124149), Oludamilola Akinmolayemi (11462668), Suzanne Saldanha (11462671), Sneha Deodhar (4705870), Colby R. Ayers (11462677)   +6 more
core   +1 more source

Influence of HDL particles on cell-cholesterol efflux under various pathological conditions[S]

Journal of Lipid Research, 2017
It has been reported that low cell-cholesterol efflux capacity (CEC) of HDL is an independent risk factor for CVD. To better understand CEC regulation, we measured ABCA1- and scavenger receptor class B type I (SR-BI)-dependent cell-cholesterol efflux ...
Bela F. Asztalos, Katalin V. Horvath, Michael Mehan, Yuya Yokota, Ernst J. Schaefer   +4 more
doaj   +1 more source

Effect of apoA-I Mutations in the Capacity of Reconstituted HDL to Promote ABCG1-Mediated Cholesterol Efflux. [PDF]

PLoS ONE, 2013
ATP binding cassette transporter G1 (ABCG1) mediates the cholesterol transport from cells to high-density lipoprotein (HDL), but the role of apolipoprotein A-I (apoA-I), the main protein constituent of HDL, in this process is not clear.
Georgios Daniil, Vassilis I Zannis, Angeliki Chroni   +2 more
doaj   +1 more source

Increased cholesterol efflux capacity in metabolic syndrome: Relation with qualitative alterations in HDL and LCAT [PDF]

, 2015
Background: Metabolic syndrome (MetS) is associated with changes in HDL levels, composition and sub-fraction profile. Whether these alterations affect HDL anti-atherogenic function, specifically measured as its capacity to perform cholesterol efflux, is ...
Lucero, Diego Martín, López, Graciela I., Svidirov, Denis, Schreier, Laura Ester, Remaley, Alan T., Fassio, Eduardo, Freeman, Lita   +6 more
core   +1 more source

Association between cholesterol efflux capacity and individual components of metabolic syndrome.

, 2021
Association between cholesterol efflux capacity and individual components of metabolic syndrome.
Parag H. Joshi (11462674), Anand Rohatgi (4917304), Ian J. Neeland (3124149), Oludamilola Akinmolayemi (11462668), Suzanne Saldanha (11462671), Sneha Deodhar (4705870), Colby R. Ayers (11462677)   +6 more
core   +1 more source

Cholesterol Efflux Capacity, High-Density Lipoprotein Particle Number, and Incident Cardiovascular Events

, 2017
Background: Recent failures of drugs that raised high-density lipoprotein (HDL) cholesterol levels to reduce cardiovascular events in clinical trials have led to increased interest in alternative indices of HDL quality, such as ...
Paul M Ridker, Olga V. Demler, Amit V. Khera, Samia Mora, Steven J. Adelman, Daniel J. Rader, Heidi L. Collins, Robert J. Glynn   +7 more
core   +1 more source

Baseline characteristics of participants across increasing quartiles of cholesterol efflux capacity–fluorescent.

, 2021
Baseline characteristics of participants across increasing quartiles of cholesterol efflux capacity–fluorescent.
Parag H. Joshi (11462674), Anand Rohatgi (4917304), Ian J. Neeland (3124149), Oludamilola Akinmolayemi (11462668), Suzanne Saldanha (11462671), Sneha Deodhar (4705870), Colby R. Ayers (11462677)   +6 more
core   +1 more source

Dual Functions of Dietary Rubber Seed Oil Supplementation: Enriching N‐3 Polyunsaturated Fatty Acids and Enhancing Antioxidant Capacity in Pekin Ducks

Animal Research and One Health, EarlyView.
Dietary RSO supplementation improved growth performance, simultaneously enriched n‐3 polyunsaturated fatty acids (n‐3 PUFA), and enhanced antioxidant capacity in Pekin ducks, which suggested that RSO has the potential to be a novel n‐3 PUFA source and an antioxidant for Pekin ducks to generate animal functional foods.
Lei Zhuang, Yongbao Wu, Zitao Zhao, Junting Cao, Yanhong Guo, Zhanyue Wu, Qimeng Wang, Peilong Yang, Sen Wu, Zhiguo Wen, Shuisheng Hou   +10 more
wiley   +1 more source