Results 101 to 110 of about 24,401 (257)

Cellular cholesterol efflux in diabetes mellitus

, 2016
Cellular cholesterol efflux is the first step of the reverse cholesterol transport pathway that transfers extrahepatic cholesterol to the liver for further metabolism.
Tsun, Gar-shun, 秦嘉信
core   +1 more source

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

High‐Density Lipoprotein Particle Concentration and Size Predict Incident Coronary Artery Disease Events in a Cohort With Type 1 Diabetes

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The cholesterol efflux capacity of high density lipoprotein (HDL) is negatively associated with cardiovascular risk. Small HDL particles account almost quantitatively for cholesterol efflux capacity, perhaps mediated through efflux of ...
Tina Costacou, Tomas Vaisar, Rachel G. Miller, W. Sean Davidson, Jay W. Heinecke, Trevor J. Orchard, Karin E. Bornfeldt   +6 more
doaj   +1 more source

Testing the role of apoA-I, HDL, and cholesterol efflux in the atheroprotective action of low-level apoE expression

Journal of Lipid Research, 2003
Low levels of transgenic mouse apolipoprotein E (apoE) suppress atherosclerosis in apoE knockout (apoE−/−) mice without normalizing plasma cholesterol.
Fayanne E. Thorngate, Patricia G. Yancey, Ginny Kellner-Weibel, Lawrence L. Rudel, George H. Rothblat, David L. Williams   +5 more
doaj   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

USF1 deficiency alleviates inflammation, enhances cholesterol efflux and prevents cholesterol accumulation in macrophages

Lipids in Health and Disease, 2018
Background The focus of studies on high-density lipoproteins (HDL) has shifted from HDL-cholesterol (HDL-C) to HDL function. We recently demonstrated that low USF1 expression in mice and humans associates with high plasma HDL-C and low triglyceride ...
Maija Ruuth, Jarkko Soronen, Essi Kaiharju, Krista Merikanto, Julia Perttilä, Jari Metso, Miriam Lee-Rueckert, Marja-Riitta Taskinen, Petri T. Kovanen, Katariina Öörni, Vesa M. Olkkonen, Matti S. Jauhiainen, Pirkka-Pekka Laurila   +12 more
doaj   +1 more source

High density lipoprotein cholesterol efflux capacity in high cardiovascular risk patients.

, 2018
High Density Lipoprotein Cholesterol Efflux Capacity in High Cardiovascular Risk Patients Introduction. Cholesterol efflux capacity is the process by which high-density lipoproteins (HDLs) can take cholesterol from macrophages and transfer them to the ...
Amšiejūtė, Rūta,
core  

HDL Cholesterol Efflux Predicts Graft Failure in Renal Transplant Recipients

, 2016
High-density lipoprotein (HDL) particles are involved in the protection against cardiovascular disease by promoting cholesterol efflux, in which accumulated cholesterol is removed from macrophage foam cells. We investigated whether HDL cholesterol efflux
Dikkers, Arne, Sanders, Jan-Stephan F, Tietge, Uwe J F, Bakker, Stephan J L; id_orcid, Dullaart, Robin P F, Bakker, Stephan J L, Sanders, Jan-Stephan F; id_orcid, Annema, Wijtske, de Boer, Jan Freark   +8 more
core   +1 more source

Test for interaction between cholesterol efflux capacity and other covariates in its association with metabolic syndrome.

, 2021
Test for interaction between cholesterol efflux capacity and other covariates in its association with metabolic syndrome.
Parag H. Joshi (11462674), Anand Rohatgi (4917304), Ian J. Neeland (3124149), Oludamilola Akinmolayemi (11462668), Suzanne Saldanha (11462671), Sneha Deodhar (4705870), Colby R. Ayers (11462677)   +6 more
core   +1 more source