Results 231 to 240 of about 38,162 (257)

Modulation of chondrocyte proliferation by ascorbic acid and BMP‐2

Journal of Cellular Physiology, 1998
Chondrocytes show an unusual ability to thrive under serum-free conditions as long as insulin, thyroxine, and cysteine are present. Studies with sternal chondrocytes from chick embryos indicate that thymidine incorporation in chondrocytes cultured under serum-free conditions is 30-50% of that seen with fetal bovine serum (FBS).
R, Venezian, B J, Shenker, S, Datar, P S, Leboy   +3 more
openaire   +2 more sources

GDF15 enhances proliferation of aged chondrocytes by phosphorylating SMAD2

Journal of Orthopaedic Science, 2022
Aging is one of the primary factors influencing development of osteoarthritis, and the TGF-β pathway plays an important role in age-related osteoarthritis. Specifically, GDF15 phosphorylates SMAD2/3 in the TGF-β pathway to inhibit cardiomyocyte hypertrophy, and promote proliferation of chondrocytes.
Dongming, Wang, Xiaochun, Wei, Xiang, Geng, Pengcui, Li, Lu, Li   +4 more
openaire   +2 more sources

Effects of Pulsed Electromagnetic Fields on Human Articular Chondrocyte Proliferation

Connective Tissue Research, 2001
Low-energy, low-frequency pulsed electromagnetic fields (PEMFs) can induce cell proliferation in several cell culture models. In this work we analysed the proliferative response of human articular chondrocytes, cultured in medium containing 10% FBS, following prolonged exposure to PEMFs (75 Hz, 2.3 mT), currently used in the treatment of some ...
Mónica De Mattei, A Caruso, Agnese Pellati   +2 more
exaly   +3 more sources

Autologous chondrocyte implantation: cells phenotype and proliferation analysis

Knee Surgery, Sports Traumatology, Arthroscopy, 2001
AbstractThe phenotype and proliferation of human chondrocytes in culture were analyzed before they were implanted as autologous graft in cartilage lesions. During ten autologous chondrocyte implantations in articular cartilage lesions of the knee in ten patients, small amounts of cells to be implanted were collected and analyzed by morphology ...
A, Gigante, C, Bevilacqua, C, Zara, M, Travasi, C, Chillemi   +4 more
openaire   +2 more sources

Lysophosphatidic acid stimulates cell proliferation in rat chondrocytes

Biochemical Pharmacology, 2005
Rat primary chondrocytes express the lysophosphatidic acid (LPA) receptor, LPA1, LPA3, but not LPA2. When chondrocytes were stimulated with LPA, phospholipase C-mediated cytosolic calcium increase was dramatically induced. LPA also stimulated two kinds of mitogen-activated protein kinase, extracellular signal-regulated kinase (ERK) and p38 kinase in ...
Mi-Kyoung, Kim, Ha-Young, Lee, Kyoung Sun, Park, Eun Ha, Shin, Seong Ho, Jo, Jeanho, Yun, Sung Won, Lee, Young Hyun, Yoo, Yun-Sik, Lee, Suk-Hwan, Baek, Yoe-Sik, Bae   +10 more
openaire   +2 more sources

Defective chondrocyte proliferation and differentiation in osteochondromas of MHE patients

Bone, 2006
Multiple hereditary exostoses (MHE) is an autosomal dominant skeletal disorder caused by mutations in one of the two EXT genes and characterized by multiple osteochondromas that generally arise near the ends of growing long bones. Defective endochondral ossification is likely to be involved in the formation of osteochondromas.
Catherine, Benoist-Lasselin, Emmanuel, de Margerie, Linda, Gibbs, Sarah, Cormier, Caroline, Silve, Gisèle, Nicolas, Martine, LeMerrer, Jean-Francois, Mallet, Arnold, Munnich, Jacky, Bonaventure, Louise, Zylberberg, Laurence, Legeai-Mallet   +11 more
openaire   +2 more sources

Inhibition of Proliferation of Chondrocytes by Specific Receptors in Response to Retinoids

Biochemical and Biophysical Research Communications, 1996
All-trans retinoic acid inhibited the proliferation of chondrocytes derived from rat xiphoid cartilage when added to the culture medium at 10(-10)-10(-8) M. Proliferation of mouse clonal osteoblastic cells was also inhibited to a significant extent by all-trans retinoic acid.
H, Hagiwara, A, Inoue, S, Nakajo, K, Nakaya, S, Kojima, S, Hirose   +5 more
openaire   +2 more sources

Isolation and In Vitro Proliferation of Chondrocytes, Tenocytes, and Ligament Cells

2003
In recent years it has become possible to grow large numbers of selected cell types in vitro from relatively small tissue samples. This capability has served as the foundation for using autogenous, as well as allogeneic, cells expanded in culture for engineering tissues that display little potential for spontaneous regeneration. Cartilage, tendons, and
S, Shortkroff, M, Spector
openaire   +2 more sources

Proliferation and differentiation of chondrocytes in cell culture.

Physiologia Bohemoslovaca, 1983
Chondrocytes freshly explanted from the sternal cartilage of 14- to 16-day-old chick embryos proliferate and differentiate in cell culture in a serum-free medium as well as in a medium containing 10% foetal calf serum. A comparable degree of multiplication and differentiation was found in chondrocytes cultivated in the serum-free medium containing ...
M, Baudysová, J, Michl
openaire   +1 more source

Stimulation by glucocorticoids of the differentiated phenotype of chondrocytes and the proliferation of rabbit costal chondrocytes in culture.

Journal of biochemistry, 1985
Hydrocortisone stimulated glycosaminoglycan (GAG) synthesis, a characteristic of the cartilage phenotype, of rabbit costal chondrocytes in confluent quiescent culture, as judged by the incorporations of [35S]sulfate and [3H]glucosamine. Hydrocortisone also stimulated incorporation of [3H]serine into proteoglycan.
T, Takano, M, Takigawa, F, Suzuki
openaire   +1 more source