Results 231 to 240 of about 731,089 (287)

Mitochondrial permeability transition in skeletal muscle phenocopies muscle alterations seen in cancer cachexia and other wasting conditions

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Skeletal muscle wasting conditions are characterized by muscle fibre atrophy, mitochondrial respiratory dysfunction, mitochondrial depletion and fragmentation of acetylcholine receptor (AChR) cluster at the neuromuscular junction.
Maya Semel   +10 more
wiley   +1 more source

Synergistic Regulation of Biomaterials and Macrophages: A Novel Paradigm in Immunotherapy

open access: yesMedComm – Biomaterials and Applications, Volume 5, Issue 4, December 2026.
Bioengineered materials mediating the modulation of macrophage plasticity and inflammatory signals in the tumor microenvironment effectively remodel immunoregulatory states, boost antitumor immunity, and promote tissue repair, achieving synergistic therapeutic outcomes.
Jiayu Zhang   +16 more
wiley   +1 more source

Comparison of Different Methods for Sensitivity Analysis Applied to a Model for Meniscus Tissue Engineering

open access: yesProceedings in Applied Mathematics and Mechanics, Volume 26, Issue 4, December 2026.
ABSTRACT Mathematical models describing physical or biological processes are often involved and need a lot of parameters whose values may be unknown and hence must be estimated. Some parameters may have a strong impact on the solution and are hence important to know in order to obtain accurate results, whereas other parameters may have little impact on
Henry Jäger, Bernd Simeon
wiley   +1 more source

Comparative Effects of Photobiomodulation and Platelet‐Rich Plasma on Joint Repair in Rats With Knee Osteoarthritis

open access: yesLasers in Surgery and Medicine, Volume 58, Issue 9, Page 802-810, November 2026.
ABSTRACT Objective This study aimed to evaluate whether the combination of photobiomodulation and platelet‐rich plasma therapy provides superior anti‐inflammatory and joint‐protective effects compared to individual treatments in an experimental model of osteoarthritis.
Anne Missrie   +5 more
wiley   +1 more source

Redefining CHI3L1: Therapeutic Opportunities at the Crossroads of Immune Suppression and Disease Progression

open access: yesMedicinal Research Reviews, Volume 46, Issue 6, Page 1897-1921, November 2026.
ABSTRACT Chitinase‐3‐like‐1 (CHI3L1, also known as YKL‐40) has been recognized as a biomarker of inflammation and tissue remodeling and has now emerged as a pseudoenzymatic immune checkpoint. Recent structural, immunological, and translational studies redefine it as an active regulator of immune suppression rather than a passive disease marker. Despite
Kirti Upmanyu   +2 more
wiley   +1 more source

Osteochondritis dissecans in the medial femoral condyle in a cat with bilateral medial patellar luxation and hip dysplasia

open access: yesVeterinary Record Case Reports, Volume 14, Issue 4, November 2026.
Abstract A 5‐month‐old female domestic shorthair cat was presented due to a 3‐month history of intermittent hindlimb lameness. Physical examination, radiographs and computed tomography were indicative of osteochondritis dissecans (OCD) in the right medial femoral condyle, accompanied by bilateral medial patellar luxation (MPL) and bilateral hip ...
Ute Wiesbauer   +3 more
wiley   +1 more source

Effectiveness of Recombinant Human Growth Hormone Therapy in Small‐for‐Gestational‐Age Children With Short Stature: A Stratified Analysis Based on Genetic Variant Status

open access: yesClinical Endocrinology, Volume 105, Issue 5, Page 556-564, November 2026.
ABSTRACT Objective This study aimed to evaluate the impact of pathogenic genetic variants on growth outcomes following 3 years of recombinant human growth hormone (rhGH) therapy in children born small for gestational age with persistent short stature (SGA‐SS). Design A retrospective cohort study.
Sanghee Park   +15 more
wiley   +1 more source

PIEZO1 Is a Contextual Mechanosensor and Its Depletion in Scx‐Lineage Cells Accelerates Structural and Functional Recovery

open access: yesThe FASEB Journal, Volume 40, Issue 19, 15 October 2026.
PIEZO1 supports adaptive matrix remodeling during tendon homeostasis but has a distinct role following injury. ScxCre‐driven Piezo1 depletion reduced Scx+ cell recruitment/accumulation within the healing defect of the patellar tendon and was associated with accelerated collagen remodeling and improved mechanical recovery.
Nicole A. Chittim   +4 more
wiley   +1 more source

What's Your Diagnosis? Large Mediastinal Mass in a Dog

open access: yes
Veterinary Clinical Pathology, EarlyView.
Rosane O. Cruz   +7 more
wiley   +1 more source

Sustainable Fabrication of Tailored Bone Substitutes: From High‐Throughput Scaffold Manufacturing, Scaled‐Up HMSC Expansion to Dynamic Cultivation in a Perfusion Bioreactor

open access: yesAdvanced Science, Volume 13, Issue 56, 9 October 2026.
ABSTRACT The demand for off‐the‐shelf biocompatible bone substitutes has driven the development of numerous independent in vitro technologies to generate products resembling physiological tissues. Due to technical challenges and overly simplified cultivation approaches/niches, the end‐products are often uniformly shaped and inferior to native bone ...
Franziska Braun   +10 more
wiley   +1 more source

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