Results 261 to 270 of about 57,848 (292)

Lysophosphatidic acid stimulates cell proliferation in rat chondrocytes

Biochemical Pharmacology, 2005
Rat primary chondrocytes express the lysophosphatidic acid (LPA) receptor, LPA1, LPA3, but not LPA2. When chondrocytes were stimulated with LPA, phospholipase C-mediated cytosolic calcium increase was dramatically induced. LPA also stimulated two kinds of mitogen-activated protein kinase, extracellular signal-regulated kinase (ERK) and p38 kinase in ...
Mi-Kyoung, Kim, Ha-Young, Lee, Kyoung Sun, Park, Eun Ha, Shin, Seong Ho, Jo, Jeanho, Yun, Sung Won, Lee, Young Hyun, Yoo, Yun-Sik, Lee, Suk-Hwan, Baek, Yoe-Sik, Bae   +10 more
openaire   +2 more sources

GDF15 enhances proliferation of aged chondrocytes by phosphorylating SMAD2

Journal of Orthopaedic Science, 2022
Aging is one of the primary factors influencing development of osteoarthritis, and the TGF-β pathway plays an important role in age-related osteoarthritis. Specifically, GDF15 phosphorylates SMAD2/3 in the TGF-β pathway to inhibit cardiomyocyte hypertrophy, and promote proliferation of chondrocytes.
Dongming, Wang, Xiaochun, Wei, Xiang, Geng, Pengcui, Li, Lu, Li   +4 more
openaire   +2 more sources

Suppression of growth plate chondrocyte proliferation by corticosteroids

Pediatric Nephrology, 2000
Growth depression is a side effect of high-dose glucocorticoid therapy in childhood. It is partially mediated by alterations of the somatotropic hormone axis and partially by direct local effects on growth plate chondrocytes. The mechanisms of interaction of corticosteroids and somatotropic and calciotropic hormones at the cellular level were recently ...
G, Klaus, C, Jux, P, Fernandez, J, Rodriguez, R, Himmele, O, Mehls   +5 more
openaire   +2 more sources

Sphingosine-1-phosphate stimulates rat primary chondrocyte proliferation

Biochemical and Biophysical Research Communications, 2006
Rat primary chondrocytes express the sphingosine-1-phosphate (S1P) receptor, S1P(2), S1P(3), S1P(4), but not S1P(1). When chondrocytes were stimulated with S1P or phytosphingosine-1-phosphate (PhS1P, an S1P(1)- and S1P(4)-selective agonist), phospholipase C-mediated cytosolic calcium increase was dramatically induced.
Mi-Kyoung, Kim, Ha Young, Lee, Jong-Young, Kwak, Joo-In, Park, Jeanho, Yun, Yoe-Sik, Bae   +5 more
openaire   +2 more sources

APOPTOSIS AND PROLIFERATION OF GROWTH PLATE CHONDROCYTES IN RABBITS

The Journal of Bone and Joint Surgery. British volume, 1997
The growth plates of the femoral head of Japanese white rabbits aged 5, 10, 15 and 20 weeks were stained for apoptotic and proliferating chondrocytes using the TUNEL and PCNA antibody staining techniques. Both TUNEL- and PCNA-positive chondrocytes were detected in all of the specimens.
T, Aizawa, S, Kokubun, Y, Tanaka
openaire   +2 more sources

Unphysiologically High Magnesium Concentrations Support Chondrocyte Proliferation and Redifferentiation

Tissue Engineering, 2006
The effect of unphysiologically high extracellular magnesium concentrations on chondrocytes, induced by the supplementation of magnesium sulfate, was studied using a 3-phase tissue engineering model. The experiments showed that chondrocyte proliferation and redifferentiation, on the gene and protein expression level, are enhanced.
Frank, Feyerabend, Frank, Witte, Michael, Kammal, Regine, Willumeit   +3 more
openaire   +2 more sources

Neuropeptide Y Promotes mTORC1 to Regulate Chondrocyte Proliferation and Hypertrophy

Endocrinology, 2023
Abstract Peripheral neuropeptide Y (NPY) has been reported to regulate bone metabolism and homeostasis; however, its potential roles in growth plate chondrogenesis remain unclear. Here, we found that NPY expression decreased during chondrocyte differentiation in vitro and in vivo.
Xiaomin Kang, Xiao Ma, Huixia Li, Xinxin Jin, Xin Gao, Dongxu Feng, Shufang Wu   +6 more
openaire   +2 more sources

The proliferation of chondrocytes and pannus in adjuvant arthritis

Virchows Archiv B Cell Pathology, 1977
Cell proliferation in the pannus formation of adjuvant arthritis was studied by autoradiography. It was found that after day 9 an increased cell proliferation starts in the joint capsule recessus and synovial villi on the injected side. From these proliferating cells a pannus, which during the first phase frequently consists only of few cell layers ...
W, Mohr, A, Wild
openaire   +2 more sources

Three-Dimensional Microenvironments Retain Chondrocyte Phenotypes During Proliferation Culture

Tissue Engineering, 2007
Although autologous chondrocyte implantation has already been in clinical use, chondrocyte dedifferentiation is problematic during proliferation culture. We attempted a three-dimensional (3D) collagen gel culture under chondrocyte proliferation with repeated passaging to prevent the chondrocytes dedifferentiation.
Tsuguharu, Takahashi, Toru, Ogasawara, Yukiyo, Asawa, Yoshiyuki, Mori, Eiju, Uchinuma, Tsuyoshi, Takato, Kazuto, Hoshi   +6 more
openaire   +2 more sources

Inhibition effect of osthole on proliferation of rat chondrocytes

Journal of Chinese Integrative Medicine, 2012
To investigate the effects of osthole on chondrocyte proliferation in vitro.Primary rat chondrocytes were isolated from the femoral head of newborn rats using collagenase digestion and cultured in Dulbecco's modified Eagle's medium. The proliferation of primary chondrocytes was assessed in second-passage cultures using cell counting kit-8 and the ...
Dao-fang, Ding, Song-pu, Wei, Xiao-feng, Li, Xiao-gang, Zhang, Hong-sheng, Zhan, Tie-li, Duan, Yue-long, Cao   +6 more
openaire   +2 more sources