Results 91 to 100 of about 16,792 (188)

Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type

Scientific Reports, 2017
Amyloid aggregates found in the brain of patients with neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, are thought to spread to increasingly larger areas of the brain through a prion-like seeding mechanism.
Elisabet Ihse, Hodaka Yamakado, Xander M. van Wijk, Roger Lawrence, Jeffrey D. Esko, Eliezer Masliah   +5 more
doaj   +1 more source

Specific genes involved in synthesis and editing of heparan sulfate proteoglycans show altered expression patterns in breast cancer

BMC Cancer, 2013
Background The expression of a specific set of genes controls the different structures of heparan sulfate proteoglycans (HSPGs), which are involved in the growth, invasion and metastatic properties of cancerous cells.
Fernández-Vega Iván, García Olivia, Crespo Ainara, Castañón Sonia, Menéndez Primitiva, Astudillo Aurora, Quirós Luis M   +6 more
doaj   +1 more source

Distribution and postnatal development of chondroitin sulfate proteoglycans in the perineuronal nets of cholinergic motoneurons innervating extraocular muscles. [PDF]

Sci Rep, 2022
Ritok A, Kiss P, Zaher A, Wolf E, Ducza L, Bacskai T, Matesz C, Gaal B.   +7 more
europepmc   +1 more source

Organ‐on‐a‐Chip Technology: Advances in Modeling Inflammation, Neurovascularization and Nociception in Human Intervertebral Disc Degeneration

Smart Medicine, Volume 5, Issue 4, August 2026.
Organ‐on‐a‐chip to miniaturize the human intervertebral disc in modeling key degenerative features, including ECM degradation, inflammation, neovascularization, sensory innervation, and nociception toward precision translation for studying disease mechanisms and therapeutic testing.
Izzat Zulkiflee, Nurul Fariha Za'aba, Abhay Pandit, Isma Liza Mohd Isa   +3 more
wiley   +1 more source

Inhibition of central axon regeneration: perspective from chondroitin sulfate proteoglycans in lamprey spinal cord injury. [PDF]

Neural Regen Res, 2022
Hu J, Jin LQ, Selzer ME.
europepmc   +1 more source

Curcumin‐Loaded GelMA Microspheres Alleviate Osteoarthritis: Transcriptomic Evidence for Immune Microenvironment Remodeling and ECM Homeostasis Restoration

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
This study provides the first multi‐model evidence combined with transcriptomic validation, demonstrating that Cur‐MS not only directly protects chondrocytes and restores extracellular matrix homeostasis but also modulates the joint inflammatory immune microenvironment.
Bin Jiang, Xin Jiang, Shaobo Li, Hao Niu, Wenbin Ji   +4 more
wiley   +1 more source

The Role of Chondroitin Sulfate Proteoglycans in Nervous System Development. [PDF]

J Histochem Cytochem, 2021
Mencio CP, Hussein RK, Yu P, Geller HM.
europepmc   +1 more source

Microtubules in Spinal Cord Injury: From Cytoskeletal Dysregulation to Therapeutic Regeneration

Journal of Neurochemistry, Volume 170, Issue 8, August 2026.
Graphical illustration of the microtubule interactome following spinal cord injury as potential targets for therapy. ABSTRACT Spinal cord injury (SCI) triggers an immediate and sustained disruption of the composition and organization of the neuronal cytoskeleton.
Itzhak Fischer, Peter W. Baas
wiley   +1 more source

Chondroitin 6-Sulfation Regulates Perineuronal Net Formation by Controlling the Stability of Aggrecan

Neural Plasticity, 2016
Perineuronal nets (PNNs) are lattice-like extracellular matrix structures composed of chondroitin sulfate proteoglycans (CSPGs). The appearance of PNNs parallels the decline of neural plasticity, and disruption of PNNs reactivates neural plasticity in ...
Shinji Miyata, Hiroshi Kitagawa
doaj   +1 more source

Chondroitin Sulfate Proteoglycans Are De Facto Cellular Receptors for Human Papillomavirus 16 under High Serum Conditions. [PDF]

J Virol, 2022
Fons NR, Kines RC, Thompson CD, Day PM, Lowy DR, Schiller JT.   +5 more
europepmc   +1 more source