Results 81 to 90 of about 16,792 (188)

Lesion Site‐Targeted Microspheres Modulate Nav1.7‐Related Signaling for Osteoarthritis Treatment

Advanced Science, Volume 13, Issue 48, 28 August 2026.
Cartilage‐targeted carbamazepine‐loaded WYRGRL‐modified composite microspheres (CBZ/WCOM) anchor to exposed type II collagen in osteoarthritic lesions and release carbamazepine under acidic conditions. This bind‐then‐release platform modulates Nav1.7‐related sodium signaling, Na⁺/Ca²⁺ exchanger‐associated Ca2+ dynamics, and heat shock protein 70 ...
Cheng Chen, Jiaying Li, Jinjin Ma, Xiaonan Yuan, Yao Xiao, Yang Zhang, Yuan Chen, Hao Jiang, Hui He, Jie Hu, Qianglong Chen, Jinniu Zhang, Bin Li, Yun Zhou, Fengxuan Han, Yong Wang   +15 more
wiley   +1 more source

Decorina e Condroitim sulfato na remodelação da matriz extracelular do línquen escleroso vulvar Decorin and chondroitin sulfate in linchen sclerosus extracellular matrix remodeling

Anais Brasileiros de Dermatologia, 2005
FUNDAMENTOS: O líquen escleroso (LS) apresenta zona de hialinização do colágeno na derme superior característica, que persiste pouco definida do ponto de vista morfológico e cujo significado permanece sem explicação.
Adriana de Carvalho Corrêa, Lúcia M.S. Azevedo, Gutemberg Leão de Almeida, Tullia Cuzzi, Christina Maeda Takiya   +4 more
doaj   +1 more source

End-functionalized glycopolymers as mimetics of chondroitin sulfate proteoglycans

Chemical Science, 2010
Glycosaminoglycans are sulfated polysaccharides that play important roles in fundamental biological processes, such as cell division, viral invasion, cancer and neuroregeneration. The multivalent presentation of multiple glycosaminoglycan chains on proteoglycan scaffolds may profoundly influence their interactions with proteins and subsequent ...
Lee, Song-Gil, Brown, Joshua M., Rogers, Claude J., Matson, John B., Krishnamurthy, Chithra, Rawat, Manish, Hsieh-Wilson, Linda C.   +6 more
openaire   +5 more sources

MicroRNAs in Spinal Cord Injury: Molecular and Translational Insights

Brain and Behavior, Volume 16, Issue 8, August 2026.
MicroRNAs (miRNAs) modulate secondary injury cascades following spinal cord injury (SCI), including inflammation, oxidative stress, apoptosis, and demyelination. Key miRNAs such as miR‐21, miR‐124, miR‐219, and miR‐223 exert neuroprotective effects by regulating astrocytic response, axon regeneration, and remyelination.
Seyyedeh Fahimeh Talebi, Hossein Kalarestaghi, Ehsan Sheikh Hesabi, Saeed Vafaei‐Nezhad   +3 more
wiley   +1 more source

Sulodexide. Nephroprotective properties and horizons for use in nephrology

Медицинский совет, 2015
Sulodexide belongs to the class of glycosaminoglycans (GAGs) or mucopolysaccharides. Found in mammalian tissuesm, GAGs regulate the activity of a wide range of proteins (including chemokines, cytokines, growth factors, enzymes, morphogens, and adhesion ...
M. M. Batyushin
doaj   +1 more source

Research Evolution and Frontiers in Glial Scar and Spinal Cord Injury Research: A Bibliometric Perspective

Brain and Behavior, Volume 16, Issue 8, August 2026.
ABSTRACT Introduction Glial scars play a key role in the pathophysiology of spinal cord injury. This study aims to systematically analyze global research trends and advances on glial scars in spinal cord injury through bibliometric methods. Method A comprehensive literature search was performed in the Web of Science Core Collection.
Shanyong Zhang, Renfeng Zhang, Yuan Qu, Tingting Hou   +3 more
wiley   +1 more source

Pleiotrophin Signals Through ALK Receptor to Enhance the Growth of Neurons in the Presence of Inhibitory Chondroitin Sulfate Proteoglycans. [PDF]

Neurosci Insights, 2023
Gupta SJ, Churchward MA, Todd KG, Winship IR.   +3 more
europepmc   +1 more source

WONOEP XVII appraisal: The role of the extracellular matrix in epilepsy

Epilepsia, Volume 67, Issue 8, Page 3894-3908, August 2026.
Abstract The extracellular matrix (ECM) is composed of proteoglycans and glycoproteins that regulate the external environment surrounding neurons, glia, and the vascular system. The ECM is vital for maintaining the structure and function of the brain and also acts as a reservoir for various signaling molecules and neurotransmitters, modulating synaptic
Eleonora Lugara, Erwin A. van Vliet, Alessia Romagnolo, Kevin Staley, Kyle P. Lillis, Chris Dulla, David C. Henshall, Katja Kobow   +7 more
wiley   +1 more source

Placental Sequestration of Plasmodium falciparum Malaria Parasites Is Mediated by the Interaction Between VAR2CSA and Chondroitin Sulfate A on Syndecan-1.

PLoS Pathogens, 2016
During placental malaria, Plasmodium falciparum infected erythrocytes sequester in the placenta, causing health problems for both the mother and fetus.
Marina Ayres Pereira, Thomas Mandel Clausen, Caroline Pehrson, Yang Mao, Mafalda Resende, Mads Daugaard, Anders Riis Kristensen, Charlotte Spliid, Line Mathiesen, Lisbeth E Knudsen, Peter Damm, Thor G Theander, Stefan R Hansson, Morten A Nielsen, Ali Salanti   +14 more
doaj   +1 more source

Keratan Sulfate: An Electroconductive Glycosaminoglycan at the Interface of Sensory Perception and Neural Signaling

Journal of Neuroscience Research, Volume 104, Issue 8, August 2026.
Laboratory studies show KS has electroconductive properties with the ability to trap and transport protons in neurotransductive processes (Grotthuss proton shuttling). This maintains electrochemical gradients and fluxes at the neuronal cell surface in neural activation. Such processes are central to neuronal cell signaling and communication.
James Melrose
wiley   +1 more source