JC Virus Agnogene Regulates Histone-Modifying Enzymes via PML-NBs: Transcriptomics in VLP-Expressing Cells [PDF]
VirusesJC virus (JCV) replicates within the nuclei of glial cells in the human brain and causes progressive multifocal leukoencephalopathy. JCV possesses a small, circular, double-stranded DNA genome, divided into early and late protein-coding regions.
Yukiko Shishido-Hara, Takeshi Yaoi
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Functional Diversity of Non-Histone Chromosomal Protein HmgB1 [PDF]
International Journal of Molecular Sciences, 2020 The functioning of DNA in the cell nucleus is ensured by a multitude of proteins, whose interactions with DNA as well as with other proteins lead to the formation of a complicated, organized, and quite dynamic system known as chromatin. This review is devoted to the description of properties and structure of the progenitors of the most abundant non ...
Elena Chikhirzhina +4 more
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The essential role of Drosophila HIRA for de novo assembly of paternal chromatin at fertilization. [PDF]
PLoS Genetics, 2007 In many animal species, the sperm DNA is packaged with male germ line--specific chromosomal proteins, including protamines. At fertilization, these non-histone proteins are removed from the decondensing sperm nucleus and replaced with maternally provided
Emilie Bonnefoy +3 more
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Discover Oncology, 2022 Morphogenesis and organogenesis in the low organisms have been found to be modulated by a number of proteins, and one of such factor, deformed epidermal auto-regulatory factor-1 (DEAF-1) has been initially identified in Drosophila.
Longji Wu +6 more
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Integration host factor of Mycobacterium tuberculosis, mIHF, compacts DNA by a bending mechanism. [PDF]
PLoS ONE, 2013 The bacterial chromosomal DNA is folded into a compact structure called as 'nucleoid' so that the bacterial genome can be accommodated inside the cell.
Arpit Mishra +8 more
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Hepatocyte Chromosomal Non‐histone Proteins in Developing Rats [PDF]
European Journal of Biochemistry, 1979 Rat hepatocytes taken at different stages of the perinatal period were partially purified. On sodium dodecylsulphate acrylamide electrophoresis chromosomal non‐histone proteins showed important variations in complexity during development. Chromosomal phosvitin kinase strongly increased during the last days of fetal life; it strongly decreased just ...
C, Guguen-Guillouzo +2 more
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The BRPF1 bromodomain is a molecular reader of di-acetyllysine
Current Research in Structural Biology, 2020 Bromodomain-containing proteins are often part of chromatin-modifying complexes, and their activity can lead to altered expression of genes that drive cancer, inflammation and neurological disorders in humans.
Juliet O. Obi +10 more
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Model of a DNA-protein complex of the architectural monomeric protein MC1 from Euryarchaea. [PDF]
PLoS ONE, 2014 In Archaea the two major modes of DNA packaging are wrapping by histone proteins or bending by architectural non-histone proteins. To supplement our knowledge about the binding mode of the different DNA-bending proteins observed across the three domains ...
Françoise Paquet +7 more
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EXPRESSION OF ONCOMARKER PROTEINS IN MAMMARY GLAND TUMOR CELLS IN CATS
Ветеринарная патология, 2022 At the present stage of the study of carcinogenesis, the main mechanism of genetically determined changes leading to uncontrolled cell malignancy is based on molecular research.
V. V. Mitenko, O. V. Dilekova
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Persistent STAT5 phosphorylation and epigenetic dysregulation of GM-CSF and PGS2/COX2 expression in Type 1 diabetic human monocytes. [PDF]
PLoS ONE, 2013 STAT5 proteins are adaptor proteins for histone acetylation enzymes. Histone acetylation at promoter and enhancer chromosomal regions opens the chromatin and allows access of transcription enzymes to specific genes in rapid response cell signals, such as
Erin Garrigan +10 more
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