Results 1 to 10 of about 92,482 (260)
Post-translational modifications of epigenetic modifier TIP60: their role in cellular functions and cancer [PDF]
Epigenetics & ChromatinTIP60 is a crucial lysine acetyltransferase protein that catalyzes the acetylation of histone and non-histone proteins. This enzyme plays a crucial role in maintaining genomic integrity, by participating in DNA damage repair, ensuring accurate ...
Himanshu Gupta, Ashish Gupta
doaj +2 more sources
Functional Diversity of Non-Histone Chromosomal Protein HmgB1 [PDF]
International Journal of Molecular Sciences, 2020 The functioning of DNA in the cell nucleus is ensured by a multitude of proteins, whose interactions with DNA as well as with other proteins lead to the formation of a complicated, organized, and quite dynamic system known as chromatin. This review is devoted to the description of properties and structure of the progenitors of the most abundant non ...
Elena Chikhirzhina +4 more
openaire +3 more sources
The essential role of Drosophila HIRA for de novo assembly of paternal chromatin at fertilization. [PDF]
PLoS Genetics, 2007 In many animal species, the sperm DNA is packaged with male germ line--specific chromosomal proteins, including protamines. At fertilization, these non-histone proteins are removed from the decondensing sperm nucleus and replaced with maternally provided
Emilie Bonnefoy +3 more
doaj +1 more source
Discover Oncology, 2022 Morphogenesis and organogenesis in the low organisms have been found to be modulated by a number of proteins, and one of such factor, deformed epidermal auto-regulatory factor-1 (DEAF-1) has been initially identified in Drosophila.
Longji Wu +6 more
doaj +1 more source
Integration host factor of Mycobacterium tuberculosis, mIHF, compacts DNA by a bending mechanism. [PDF]
PLoS ONE, 2013 The bacterial chromosomal DNA is folded into a compact structure called as 'nucleoid' so that the bacterial genome can be accommodated inside the cell.
Arpit Mishra +8 more
doaj +1 more source
Hepatocyte Chromosomal Non‐histone Proteins in Developing Rats [PDF]
European Journal of Biochemistry, 1979 Rat hepatocytes taken at different stages of the perinatal period were partially purified. On sodium dodecylsulphate acrylamide electrophoresis chromosomal non‐histone proteins showed important variations in complexity during development. Chromosomal phosvitin kinase strongly increased during the last days of fetal life; it strongly decreased just ...
Lydie Tichonicky +2 more
openaire +3 more sources
Model of a DNA-protein complex of the architectural monomeric protein MC1 from Euryarchaea. [PDF]
PLoS ONE, 2014 In Archaea the two major modes of DNA packaging are wrapping by histone proteins or bending by architectural non-histone proteins. To supplement our knowledge about the binding mode of the different DNA-bending proteins observed across the three domains ...
Françoise Paquet +7 more
doaj +1 more source
Persistent STAT5 phosphorylation and epigenetic dysregulation of GM-CSF and PGS2/COX2 expression in Type 1 diabetic human monocytes. [PDF]
PLoS ONE, 2013 STAT5 proteins are adaptor proteins for histone acetylation enzymes. Histone acetylation at promoter and enhancer chromosomal regions opens the chromatin and allows access of transcription enzymes to specific genes in rapid response cell signals, such as
Erin Garrigan +10 more
doaj +1 more source
PLoS Genetics, 2021 Aberrant repair of DNA double-strand breaks can recombine distant chromosomal breakpoints. Chromosomal rearrangements compromise genome function and are a hallmark of ageing.
David A Ellis +9 more
doaj +1 more source
Degradation of RNA during lysis of Escherichia coli cells in agarose plugs breaks the chromosome. [PDF]
PLoS ONE, 2017 The nucleoid of Escherichia coli comprises DNA, nucleoid associated proteins (NAPs) and RNA, whose role is unclear. We found that lysing bacterial cells embedded in agarose plugs in the presence of RNases caused massive fragmentation of the chromosomal ...
Sharik R Khan, Andrei Kuzminov
doaj +1 more source