JC Virus Agnogene Regulates Histone-Modifying Enzymes via PML-NBs: Transcriptomics in VLP-Expressing Cells [PDF]
VirusesJC virus (JCV) replicates within the nuclei of glial cells in the human brain and causes progressive multifocal leukoencephalopathy. JCV possesses a small, circular, double-stranded DNA genome, divided into early and late protein-coding regions.
Yukiko Shishido-Hara, Takeshi Yaoi
doaj +2 more sources
The essential role of Drosophila HIRA for de novo assembly of paternal chromatin at fertilization. [PDF]
PLoS Genetics, 2007 In many animal species, the sperm DNA is packaged with male germ line--specific chromosomal proteins, including protamines. At fertilization, these non-histone proteins are removed from the decondensing sperm nucleus and replaced with maternally provided
Emilie Bonnefoy +3 more
doaj +1 more source
Discover Oncology, 2022 Morphogenesis and organogenesis in the low organisms have been found to be modulated by a number of proteins, and one of such factor, deformed epidermal auto-regulatory factor-1 (DEAF-1) has been initially identified in Drosophila.
Longji Wu +6 more
doaj +1 more source
Integration host factor of Mycobacterium tuberculosis, mIHF, compacts DNA by a bending mechanism. [PDF]
PLoS ONE, 2013 The bacterial chromosomal DNA is folded into a compact structure called as 'nucleoid' so that the bacterial genome can be accommodated inside the cell.
Arpit Mishra +8 more
doaj +1 more source
The BRPF1 bromodomain is a molecular reader of di-acetyllysine
Current Research in Structural Biology, 2020 Bromodomain-containing proteins are often part of chromatin-modifying complexes, and their activity can lead to altered expression of genes that drive cancer, inflammation and neurological disorders in humans.
Juliet O. Obi +10 more
doaj +1 more source
Model of a DNA-protein complex of the architectural monomeric protein MC1 from Euryarchaea. [PDF]
PLoS ONE, 2014 In Archaea the two major modes of DNA packaging are wrapping by histone proteins or bending by architectural non-histone proteins. To supplement our knowledge about the binding mode of the different DNA-bending proteins observed across the three domains ...
Françoise Paquet +7 more
doaj +1 more source
EXPRESSION OF ONCOMARKER PROTEINS IN MAMMARY GLAND TUMOR CELLS IN CATS
Ветеринарная патология, 2022 At the present stage of the study of carcinogenesis, the main mechanism of genetically determined changes leading to uncontrolled cell malignancy is based on molecular research.
V. V. Mitenko, O. V. Dilekova
doaj +1 more source
Persistent STAT5 phosphorylation and epigenetic dysregulation of GM-CSF and PGS2/COX2 expression in Type 1 diabetic human monocytes. [PDF]
PLoS ONE, 2013 STAT5 proteins are adaptor proteins for histone acetylation enzymes. Histone acetylation at promoter and enhancer chromosomal regions opens the chromatin and allows access of transcription enzymes to specific genes in rapid response cell signals, such as
Erin Garrigan +10 more
doaj +1 more source
PLoS Genetics, 2021 Aberrant repair of DNA double-strand breaks can recombine distant chromosomal breakpoints. Chromosomal rearrangements compromise genome function and are a hallmark of ageing.
David A Ellis +9 more
doaj +1 more source
Degradation of RNA during lysis of Escherichia coli cells in agarose plugs breaks the chromosome. [PDF]
PLoS ONE, 2017 The nucleoid of Escherichia coli comprises DNA, nucleoid associated proteins (NAPs) and RNA, whose role is unclear. We found that lysing bacterial cells embedded in agarose plugs in the presence of RNases caused massive fragmentation of the chromosomal ...
Sharik R Khan, Andrei Kuzminov
doaj +1 more source