Results 11 to 20 of about 119,158 (272)
PLoS Genetics, 2021 Aberrant repair of DNA double-strand breaks can recombine distant chromosomal breakpoints. Chromosomal rearrangements compromise genome function and are a hallmark of ageing.
David A Ellis +9 more
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Impact of histone H4 lysine 20 methylation on 53BP1 responses to chromosomal double strand breaks. [PDF]
, 2012 Recruitment of 53BP1 to chromatin flanking double strand breaks (DSBs) requires γH2AX/MDC1/RNF8-dependent ubiquitination of chromatin and interaction of 53BP1 with histone H4 methylated on lysine 20 (H4K20me). Several histone methyltransferases have been
Guan, Yinghua +7 more
core +13 more sources
Degradation of RNA during lysis of Escherichia coli cells in agarose plugs breaks the chromosome. [PDF]
PLoS ONE, 2017 The nucleoid of Escherichia coli comprises DNA, nucleoid associated proteins (NAPs) and RNA, whose role is unclear. We found that lysing bacterial cells embedded in agarose plugs in the presence of RNases caused massive fragmentation of the chromosomal ...
Sharik R Khan, Andrei Kuzminov
doaj +1 more source
SUMO control of centromere homeostasis
Frontiers in Cell and Developmental Biology, 2023 Centromeres are unique chromosomal loci that form the anchorage point for the mitotic spindle during mitosis and meiosis. Their position and function are specified by a unique chromatin domain featuring the histone H3 variant CENP-A.
Sebastiaan J. W. van den Berg +2 more
doaj +1 more source
The DNA intercalators ethidium bromide and propidium iodide also bind to core histones
FEBS Open Bio, 2014 Eukaryotic DNA is compacted in the form of chromatin, in a complex with histones and other non-histone proteins. The intimate association of DNA and histones in chromatin raises the possibility that DNA-interactive small molecules may bind to chromatin ...
Amrita Banerjee +6 more
doaj +1 more source
PLoS ONE, 2023 Acetylation of lysine residues is an important and common post-translational regulatory mechanism occurring on thousands of non-histone proteins. Lysine deacetylases (KDACs or HDACs) are a family of enzymes responsible for removing acetylation.
Tasha B Toro +4 more
doaj +1 more source
HIPK2 and extrachromosomal histone H2B are separately recruited by Aurora-B for cytokinesis [PDF]
, 2018 Cytokinesis, the final phase of cell division, is necessary to form two distinct daughter cells with correct distribution of genomic and cytoplasmic materials.
A Konishi +65 more
core +1 more source
Selfish chromosomal drive shapes recent centromeric histone evolution in monkeyflowers.
PLoS Genetics, 2021 Centromeres are essential mediators of chromosomal segregation, but both centromeric DNA sequences and associated kinetochore proteins are paradoxically diverse across species.
Findley R Finseth +2 more
doaj +1 more source
PARP-3 and APLF function together to accelerate nonhomologous end joining [PDF]
, 2010 PARP-3 is a member of the ADP-ribosyl transferase superfamily of unknown function. We show that PARP-3 is stimulated by DNA double-strand breaks (DSBs) in vitro and functions in the same pathway as the poly (ADP-ribose)-binding protein APLF to accelerate
Ahel +59 more
core +1 more source
VEZF1 elements mediate protection from DNA methylation [PDF]
, 2010 There is growing consensus that genome organization and long-range gene regulation involves partitioning of the genome into domains of distinct epigenetic chromatin states.
AC Bell +54 more
core +5 more sources