Comprehensive analysis of the chromatin landscape in Drosophila melanogaster. [PDF]
, 2010 Chromatin is composed of DNA and a variety of modified histones and non-histone proteins, which have an impact on cell differentiation, gene regulation and other key cellular processes.
Alekseyenko, Artyom A +29 more
core +4 more sources
UBR2 of the N-end rule pathway is required for chromosome stability via histone ubiquitylation in spermatocytes and somatic cells [PDF]
, 2012 The N-end rule pathway is a proteolytic system in which its recognition components (N-recognins) recognize destabilizing N-terminal residues of short-lived proteins as an essential element of specific degrons, called N-degrons.
An, JY +12 more
core +1 more source
Spt2p defines a new transcription-dependent gross chromosomal rearrangement pathway.
PLoS Genetics, 2008 Large numbers of gross chromosomal rearrangements (GCRs) are frequently observed in many cancers. High mobility group 1 (HMG1) protein is a non-histone DNA-binding protein and is highly expressed in different types of tumors.
Nilabja Sikdar +4 more
doaj +1 more source
c-Myc-Induced Extrachromosomal Elements Carry Active Chromatin
Neoplasia: An International Journal for Oncology Research, 2003 Murine Pre-13 lymphocytes with experimentally activated MycER show both chromosomal and extrachromosomal gene amplification. In this report, we have elucidated the size, structure, functional components of c-Myc-induced extrachromosomal elements (EEs ...
Greg Smith +5 more
doaj +1 more source
CenH3 distribution reveals extended centromeres in the model beetle Tribolium castaneum.
PLoS Genetics, 2020 Centromeres are chromosomal domains essential for kinetochore assembly and correct chromosome segregation. Inconsistent in their underlying DNA sequences, centromeres are defined epigenetically by the presence of the centromere-specific histone H3 ...
Tena Gržan +4 more
doaj +1 more source
Sequence-specific targeting of dosage compensation in Drosophila favors an active chromatin context. [PDF]
PLoS Genetics, 2012 The Drosophila MSL complex mediates dosage compensation by increasing transcription of the single X chromosome in males approximately two-fold. This is accomplished through recognition of the X chromosome and subsequent acetylation of histone H4K16 on X ...
Artyom A Alekseyenko +18 more
doaj +1 more source
Histone H3 lysine 56 acetylation by Rtt109 is crucial for chromosome positioning [PDF]
, 2008 Peer reviewedPublisher ...
Botsios, Sotirios +2 more
core +3 more sources
Emerging roles of telomeric chromatin alterations in cancer [PDF]
, 2019 Telomeres, the nucleoprotein structures that cap the ends of eukaryotic chromosomes, play important and multiple roles in tumorigenesis. Functional telomeres need the establishment of a protective chromatin structure based on the interplay between the ...
Biroccio, Annamaria +2 more
core +1 more source
DNA Modifications: Function and Applications in Normal and Disease States
Biology, 2014 Epigenetics refers to a variety of processes that have heritable effects on gene expression programs without changes in DNA sequence. Key players in epigenetic control are chemical modifications to DNA, histone, and non-histone chromosomal proteins ...
Vichithra R. B. Liyanage +5 more
doaj +1 more source
Chipping away at gamma-H2AX foci [PDF]
, 2009 The mammalian histone H2AX protein functions as a dosage-dependent genomic caretaker and tumor suppressor. Phosphorylation of H2AX to form gamma-H2AX in chromatin around DNA double strand breaks (DSBs) is an early event following induction of these ...
Bassing, Craig H +3 more
core +1 more source