Results 21 to 30 of about 92,482 (260)

Endogenous expression of inactive lysine deacetylases reveals deacetylation-dependent cellular mechanisms.

PLoS ONE, 2023
Acetylation of lysine residues is an important and common post-translational regulatory mechanism occurring on thousands of non-histone proteins. Lysine deacetylases (KDACs or HDACs) are a family of enzymes responsible for removing acetylation.
Tasha B Toro, Elena V Skripnikova, Kiara E Bornes, Kun Zhang, Terry J Watt   +4 more
doaj   +1 more source

Spt2p defines a new transcription-dependent gross chromosomal rearrangement pathway.

PLoS Genetics, 2008
Large numbers of gross chromosomal rearrangements (GCRs) are frequently observed in many cancers. High mobility group 1 (HMG1) protein is a non-histone DNA-binding protein and is highly expressed in different types of tumors.
Nilabja Sikdar, Soma Banerjee, Han Zhang, Stephanie Smith, Kyungjae Myung   +4 more
doaj   +1 more source

Sequence-specific targeting of dosage compensation in Drosophila favors an active chromatin context. [PDF]

PLoS Genetics, 2012
The Drosophila MSL complex mediates dosage compensation by increasing transcription of the single X chromosome in males approximately two-fold. This is accomplished through recognition of the X chromosome and subsequent acetylation of histone H4K16 on X ...
Artyom A Alekseyenko, Joshua W K Ho, Shouyong Peng, Marnie Gelbart, Michael Y Tolstorukov, Annette Plachetka, Peter V Kharchenko, Youngsook L Jung, Andrey A Gorchakov, Erica Larschan, Tingting Gu, Aki Minoda, Nicole C Riddle, Yuri B Schwartz, Sarah C R Elgin, Gary H Karpen, Vincenzo Pirrotta, Mitzi I Kuroda, Peter J Park   +18 more
doaj   +1 more source

c-Myc-Induced Extrachromosomal Elements Carry Active Chromatin

Neoplasia: An International Journal for Oncology Research, 2003
Murine Pre-13 lymphocytes with experimentally activated MycER show both chromosomal and extrachromosomal gene amplification. In this report, we have elucidated the size, structure, functional components of c-Myc-induced extrachromosomal elements (EEs ...
Greg Smith, Cheryl Taylor-Kashton, Len Dushnicky, Stephen Symons, Jim Wright, Sabine Mai   +5 more
doaj   +1 more source

CenH3 distribution reveals extended centromeres in the model beetle Tribolium castaneum.

PLoS Genetics, 2020
Centromeres are chromosomal domains essential for kinetochore assembly and correct chromosome segregation. Inconsistent in their underlying DNA sequences, centromeres are defined epigenetically by the presence of the centromere-specific histone H3 ...
Tena Gržan, Evelin Despot-Slade, Nevenka Meštrović, Miroslav Plohl, Brankica Mravinac   +4 more
doaj   +1 more source

Studies on the tissue specificity of the high-mobility-group non-histone chromosomal proteins from calf.

Biochemical Journal, 1978
The high-mobility-group (HMG) non-histone chromosomal proteins from calf thymus, liver, spleen and kidney were extracted, and fractionated by CM-Sephadex chromatography and trichloroacetic acid precipitation. The isolated proteins HMG 1, HMG 2 and HMG 17
A. Rabbani, G. Goodwin, E. W. Johns
semanticscholar   +1 more source

The isolation, characterization and partial sequences of the chicken erythrocyte non-histone chromosomal proteins HMG14 and HMG17. Comparison with the homologous calf thymus proteins.

Biochemical Journal, 1980
Non-histone chromosomal proteins HMG14 and HMG17 were isolated from chicken erythrocyte nuclei. The proteins were characterized by amino acid analysis and by N-terminal sequence analyses.
J. Walker, E. W. Johns
semanticscholar   +1 more source

DNA Modifications: Function and Applications in Normal and Disease States

Biology, 2014
Epigenetics refers to a variety of processes that have heritable effects on gene expression programs without changes in DNA sequence. Key players in epigenetic control are chemical modifications to DNA, histone, and non-histone chromosomal proteins ...
Vichithra R. B. Liyanage, Jessica S. Jarmasz, Nanditha Murugeshan, Marc R. Del Bigio, Mojgan Rastegar, James R. Davie   +5 more
doaj   +1 more source

Non-histone chromosomal proteins. Evidence for their role in mediating the binding of histones to deoxyribonucleic acid during the cell cycle.

Biochemical Journal, 1974
By selective dissociation of histones with the ionic detergent sodium deoxycholate, we have demonstrated that these basic chromosomal polypeptides, which are effective inhibitors of transcription, are more tenaciously bound to DNA in mitotic than in S ...
G. S. Stein, Gale D. Hunter, Lena Lavie
semanticscholar   +1 more source

Epigenetics and airways disease

Respiratory Research, 2006
Epigenetics is the term used to describe heritable changes in gene expression that are not coded in the DNA sequence itself but by post-translational modifications in DNA and histone proteins. These modifications include histone acetylation, methylation,
Ito Kazuhiro, Ford Paul, Adcock Ian M, Barnes P J   +3 more
doaj   +1 more source