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Chromosome segregation in plant meiosis [PDF]
Frontiers in Plant Science, 2014 Faithful chromosome segregation in meiosis is essential for ploidy stability over sexual life cycles. In plants, defective chromosome segregation caused by gene mutations or other factors leads to the formation of unbalanced or unreduced gametes creating
Linda eZamariola +4 more
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Exotic mitotic mechanisms [PDF]
Open Biology, 2012 The emergence of eukaryotes around two billion years ago provided new challenges for the chromosome segregation machineries: the physical separation of multiple large and linear chromosomes from the microtubule-organizing centres by the nuclear envelope.
Hauke Drechsler, Andrew D. McAinsh
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mBio, 2012 Vibrio cholerae has two chromosomes (chrI and chrII) whose replication and segregation are under different genetic controls. The region covering the replication origin of chrI resembles that of the Escherichia coli chromosome, and both origins are under ...
Ryosuke Kadoya, Dhruba K. Chattoraj
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Coordination of Chromosome Segregation and Cell Division in Staphylococcus aureus [PDF]
Frontiers in Microbiology, 2017 Productive bacterial cell division and survival of progeny requires tight coordination between chromosome segregation and cell division to ensure equal partitioning of DNA.
Amy L. Bottomley +6 more
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Age-cumulative effect of REC8 reduction on meiotic chromosome segregation errors in mice
Reproductive and Developmental Medicine, 2021 Objective: This study aimed to explore the relationship between cohesin subunit REC8 reduction and meiosis chromosome segregation errors in the ovary. Methods: Rec8+/− mice were generated using CRIPSR/Cas9 gene editing.
Li-Yuan Tian +5 more
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NuSAP4 regulates chromosome segregation in Trypanosoma brucei by promoting bipolar spindle assembly [PDF]
Communications BiologyFaithful chromosome segregation in eukaryotes requires the assembly of a bipolar spindle and the faithful attachment of kinetochores to spindle microtubules, which are regulated by various spindle-associated proteins (SAPs) that play distinct functions ...
Qing Zhou, Ziyin Li
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The mitotic ATR-Chk1 pathway promotes CDK1 activity for faithful chromosome segregation. [PDF]
Cell RepJoo YK +7 more
europepmc +3 more sources
Sod1 deficiency in mouse oocytes during in vitro maturation increases chromosome segregation errors with a reduced BUBR1 at kinetochore [PDF]
Reproductive Medicine and BiologyPurpose This study aimed to investigate the molecular mechanisms associated with chromosome segregation errors caused by intrinsic oxidative stress during in vitro oocyte maturation (IVM) using oocytes from Sod1‐deficient (Sod1KO) mice.
Mitsuru Nago +5 more
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A Brownian ratchet model for DNA loop extrusion by the cohesin complex
eLife, 2021 The cohesin complex topologically encircles DNA to promote sister chromatid cohesion. Alternatively, cohesin extrudes DNA loops, thought to reflect chromatin domain formation. Here, we propose a structure-based model explaining both activities.
Torahiko L Higashi +4 more
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Functional crosstalk between the cohesin loader and chromatin remodelers
Nature Communications, 2022 Chromatin remodelers direct the cohesin loader to nucleosome depleted regions where cohesin accesses chromosomes. Muñoz et al. now show that the cohesin loader in turn is a biochemical activator of a chromatin remodeler, helping to clear ...
Sofía Muñoz +5 more
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