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Chromosome segregation in plant meiosis [PDF]
Frontiers in Plant Science, 2014 Faithful chromosome segregation in meiosis is essential for ploidy stability over sexual life cycles. In plants, defective chromosome segregation caused by gene mutations or other factors leads to the formation of unbalanced or unreduced gametes creating aneuploid or polyploid progeny, respectively.
Zamariola, Linda +4 more
core +11 more sources
Mechanical Mechanisms of Chromosome Segregation [PDF]
Cells, 2021 Chromosome segregation—the partitioning of genetic material into two daughter cells—is one of the most crucial processes in cell division. In all Eukaryotes, chromosome segregation is driven by the spindle, a microtubule-based, self-organizing subcellular structure.
Maya I. Anjur-Dietrich +2 more
openaire +5 more sources
Cohesin and chromosome segregation [PDF]
Current Biology, 2018 Cohesin is a ring-shaped protein complex that organises the genome, enabling its condensation, expression, repair and transmission. Cohesin is best known for its role in chromosome segregation, where it provides the cohesion that is established between the two newly duplicated sister chromatids during S phase.
Makrantoni, Vasso, Marston, Adele L
openaire +5 more sources
Double-checking chromosome segregation. [PDF]
J Cell Biol, 2023 Enduring chromosome segregation errors represent potential threats to genomic stability due to eventual chromosome copy number alterations (aneuploidy) and formation of micronuclei—key intermediates of a rapid mutational process known as chromothripsis that is found in cancer and congenital disorders.
Maiato H, Silva S.
europepmc +3 more sources
Mechanisms for Chromosome Segregation in Bacteria [PDF]
Frontiers in Microbiology, 2021 The process of DNA segregation, the redistribution of newly replicated genomic material to daughter cells, is a crucial step in the life cycle of all living systems. Here, we review DNA segregation in bacteria which evolved a variety of mechanisms for partitioning newly replicated DNA.
Gogou, C. (author) +2 more
openaire +6 more sources
Theory of Active Intracellular Transport by DNA-relaying [PDF]
Phys. Rev. Lett. 127, 138101 (2021), 2021 The spatiotemporal organization of bacterial cells is crucial for the active segregation of replicating chromosomes. In several species, including Caulobacter crescentus, the ATPase ParA binds to DNA and forms a gradient along the long cell axis.
arxiv +1 more source
Chromosome segregation in Eubacteria [PDF]
Current Opinion in Microbiology, 2003 It is now clear that bacterial chromosomes rapidly separate in a manner independent of cell elongation, suggesting the existence of a mitotic apparatus in bacteria. Recent studies of bacterial cells reveal filamentous structures similar to the eukaryotic cytoskeleton, proteins that mediate polar chromosome anchoring during Bacillus subtilis sporulation,
Kit Pogliano +2 more
openaire +3 more sources
Developmental Cell, 2002 During mitosis, in most eukaryotes, cohesin is removed from chromosomes in two steps. A paper in the March issue of Molecular Cell identifies Polo-like kinase as a key regulator for the first step that releases much of cohesin during prophase.
Stefan Weitzer, Frank Uhlmann
openaire +3 more sources
Current Opinion in Microbiology, 2001 The ability to visualise specific genes and proteins within bacterial cells is revolutionising knowledge of chromosome segregation. The essential elements appear to be the driving force behind DNA replication, which occurs at fixed cellular positions, the condensation of newly replicated DNA by a chromosome condensation machine located at the cell 1/4 ...
Sherratt, D, Lau, I, Barre, F
openaire +2 more sources
Chromosome Segregation: Disarming the Protector [PDF]
Current Biology, 2013 One of the key features of meiosis is that shugoshin in complex with protein phosphatase 2A (PP2A) protects centromeric cohesin during meiosis I, but not during meiosis II. A new model suggests that a PP2A inhibitor mediates deprotection of centromeric cohesin during meiosis II.
Swastika Sanyal +4 more
openaire +3 more sources