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Mechanical Mechanisms of Chromosome Segregation [PDF]
Cells, 2021 Chromosome segregation—the partitioning of genetic material into two daughter cells—is one of the most crucial processes in cell division. In all Eukaryotes, chromosome segregation is driven by the spindle, a microtubule-based, self-organizing ...
Maya I. Anjur-Dietrich +2 more
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Double-checking chromosome segregation. [PDF]
J Cell Biol, 2023 Enduring chromosome segregation errors represent potential threats to genomic stability due to eventual chromosome copy number alterations (aneuploidy) and formation of micronuclei—key intermediates of a rapid mutational process known as chromothripsis that is found in cancer and congenital disorders.
Maiato H, Silva S.
europepmc +3 more sources
Bacterial chromosome segregation by the ParABS system [PDF]
Open Biology, 2020 Proper chromosome segregation during cell division is essential in all domains of life. In the majority of bacterial species, faithful chromosome segregation is mediated by the tripartite ParABS system, consisting of an ATPase protein ParA, a CTPase and ...
Adam S. B. Jalal, Tung B. K. Le
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The coordination of nuclear envelope assembly and chromosome segregation in metazoans
Nucleus, 2020 The nuclear envelope (NE) is composed of two lipid bilayer membranes that enclose the eukaryotic genome. In interphase, the NE is perforated by thousands of nuclear pore complexes (NPCs), which allow transport in and out of the nucleus. During mitosis in
Shiwei Liu, David Pellman
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Role of the Number of Microtubules in Chromosome Segregation during Cell Division [PDF]
PLoS ONE 10(10): e0141305 (2015), 2015 Faithful segregation of genetic material during cell division requires alignment of chromosomes between two spindle poles and attachment of their kinetochores to each of the poles. Failure of these complex dynamical processes leads to chromosomal instability (CIN), a characteristic feature of several diseases including cancer.
Z. Bertalan +3 more
arxiv +3 more sources
Chromosome segregation in plant meiosis [PDF]
Frontiers in Plant Science, 2014 Faithful chromosome segregation in meiosis is essential for ploidy stability over sexual life cycles. In plants, defective chromosome segregation caused by gene mutations or other factors leads to the formation of unbalanced or unreduced gametes creating
Linda eZamariola +4 more
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NuSAP4 regulates chromosome segregation in Trypanosoma brucei by promoting bipolar spindle assembly [PDF]
Communications BiologyFaithful chromosome segregation in eukaryotes requires the assembly of a bipolar spindle and the faithful attachment of kinetochores to spindle microtubules, which are regulated by various spindle-associated proteins (SAPs) that play distinct functions ...
Qing Zhou, Ziyin Li
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Nuclear Organization and Chromosome Segregation [PDF]
The Plant Cell, 1999 The genetic information underlying plant form and function is contained within the cell nucleus in the form of complex, dynamic DNA–protein structures—the chromosomes. The faithful transmission of these structures during mitosis and meiosis requires extensive chromosome reorganization and ...
A. E. Franklin, W. Zacheus Cande
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Coordination of Chromosome Segregation and Cell Division in Staphylococcus aureus
Frontiers in Microbiology, 2017 Productive bacterial cell division and survival of progeny requires tight coordination between chromosome segregation and cell division to ensure equal partitioning of DNA.
Amy L. Bottomley +6 more
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Kinetochore-independent chromosome segregation driven by lateral microtubule bundles
eLife, 2015 During cell division, chromosomes attach to spindle microtubules at sites called kinetochores, and force generated at the kinetochore-microtubule interface is the main driver of chromosome movement.
Christina C Muscat +4 more
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