Modulation of PGC-1α activity as a treatment for metabolic and muscle-related diseases [PDF]
, 2014 Physical inactivity is a predisposing factor for various disease states including obesity, cardiovascular disease, as well as for certain types of cancer. Regular endurance exercise mediates several beneficial effects such as increased energy expenditure
Handschin, Christoph +1 more
core +1 more source
Large animal models for chronic wasting disease [PDF]
Cell and Tissue Research, 2022 Chronic wasting disease (CWD) is a fatal neurodegenerative prion disease of cervid species including deer, elk, moose and reindeer. The disease has shown both geographic and species expansion since its discovery in the late 1960's and is now recognized in captive and free-ranging cervid populations in North America, Asia and Europe.
openaire +2 more sources
Exposure Risk of Chronic Wasting Disease in Humans
Viruses, 2020 The majority of human prion diseases are sporadic, but acquired disease can occur, as seen with variant Creutzfeldt–Jakob disease (vCJD) following consumption of bovine spongiform encephalopathy (BSE).
Satish K. Nemani +4 more
doaj +1 more source
The potential therapeutic effects of creatine supplementation on body composition and muscle function in cancer [PDF]
, 2018 Low muscle mass in individuals with cancer has a profound impact on quality of life and independence and is associated with greater treatment toxicity and poorer prognosis.
Fairman, C M +5 more
core +2 more sources
Severe malnutrition in children presenting to health facilities in an urban slum in Bangladesh [PDF]
, 2012 SETTING: An urban slum in Kamrangirchar, Bangladesh. OBJECTIVES: Among children aged 6–59 months seeking medical care from the two Médecins Sans Frontières-supported primary health centres, to determine 1) the prevalence of severe acute malnutrition (SAM)
Alders, P +12 more
core +3 more sources
Susceptibilities of Nonhuman Primates to Chronic Wasting Disease
Emerging Infectious Diseases, 2009 Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy, or prion disease, that affects deer, elk, and moose. Human susceptibility to CWD remains unproven despite likely exposure to CWD-infected cervids.
Brent Race +16 more
doaj +1 more source
Spatiotemporal epizootiology of chronic wasting disease in Wisconsin deer
Ecosphere, 2023 Chronic wasting disease (CWD) is a fatal neurological disease of cervids caused by a misfolded protein with no vaccines or other cures to prevent infection and death.
Michael D. Samuel
doaj +1 more source
Prion seeding activity in DNA extractions: implications for laboratory biosafety
PrionInfectious prions (PrPSc) are largely resistant to proteolytic digestion, including proteinase K (PK) digestion. While nucleic acid extracts are generally considered non-infectious from a classical microbiology context (i.e.
Sarah C. Gresch +10 more
doaj +1 more source
Cellular interplay in skeletal muscle regeneration and wasting: insights from animal models
Journal of Cachexia, Sarcopenia and Muscle, 2023 Skeletal muscle wasting, whether related to physiological ageing, muscle disuse or to an underlying chronic disease, is a key determinant to quality of life and mortality.
Pauline Henrot +8 more
doaj +1 more source
Six-Month Mortality among HIV-Infected Adults Presenting for Antiretroviral Therapy with Unexplained Weight Loss, Chronic Fever or Chronic Diarrhea in Malawi. [PDF]
, 2012 In sub-Saharan Africa, early mortality is high following initiation of antiretroviral therapy (ART). We investigated 6-month outcomes and factors associated with mortality in HIV-infected adults being assessed for ART initiation and presenting with ...
AD Kerkhoff +50 more
core +3 more sources