Results 131 to 140 of about 45,661 (289)
Advanced Science, EarlyView.CircSMPD4 physically combines with lactate dehydrogenase A (LDHA) and reduces its acetylation level via SIRT2‐dependent deacetylation, thereby inhibiting chaperone‐mediated autophagy‐lysosome degradation of LDHA. Upregulating LDHA leads to increasing lactate production and extracellular export, which in turn suppresses natural killer cell cytotoxicity ...
Hao Shen +16 more
wiley +1 more source
Research progress of circRNA in malignant tumour metabolic reprogramming
RNA Biology, 2023 Cancer is a multi-factor systemic malignant disease, which has seriously threatened human health and created a heavy burden on the world economy. Metabolic reprogramming, one of the important signs of malignant tumours, provides necessary nutrition for ...
Yikun Geng +5 more
doaj +1 more source
Advanced Science, EarlyView.This study reveals that CAFs‐derived EVs enriched with circTAX1BP1 drive CRLM by promoting VIRMA lactylation and SP1/TGF‐β signaling, creating a positive feedback loop via ITGA11+ myCAFs. Targeting EV‐circTAX1BP1 and TGF‐β disrupts this loop, offering a novel therapeutic strategy for CRLM.
Jia‐nan Tan +12 more
wiley +1 more source
Genome-Wide Profiling of Circular RNAs in the Rapidly Growing Shoots of Moso Bamboo (Phyllostachys edulis). [PDF]
, 2019 Circular RNAs, including circular exonic RNAs (circRNA), circular intronic RNAs (ciRNA) and exon-intron circRNAs (EIciRNAs), are a new type of noncoding RNAs.
Gao, Yubang +13 more
core
Multiple Isoforms of ANRIL in Melanoma Cells: Structural Complexity Suggests Variations in Processing [PDF]
, 2017 The long non-coding RNA ANRIL, antisense to the CDKN2B locus, is transcribed from a gene that encompasses multiple disease-associated polymorphisms. Despite the identification of multiple isoforms of ANRIL, expression of certain transcripts has been ...
Askarian-Amiri, Marjan E. +7 more
core +1 more source
Advanced Intelligent Discovery, EarlyView.Exosomes are emerging as powerful biomarkers for disease diagnosis and monitoring. This review highlights the integration of surface‐enhanced Raman spectroscopy with artificial intelligence to enhance molecular fingerprinting of exosomes. Machine learning and deep learning techniques improve spectral interpretation, enabling accurate classification of ...
Munevver Akdeniz +2 more
wiley +1 more source
The RNA workbench: Best practices for RNA and high-throughput sequencing bioinformatics in Galaxy [PDF]
, 2017 RNA-based regulation has become a major research topic in molecular biology. The analysis of epigenetic and expression data is therefore incomplete if RNA-based regulation is not taken into account. Thus, it is increasingly important but not yet standard
Akalin, A. (Altuna) +19 more
core +8 more sources
circRNA-miRNA-mRNA regulatory network in human lung cancer: an update
Cancer Cell International, 2020 Circular RNAs, as hopeful diagnosis markers and therapeutic molecules, have been studied, probed and applied into several diseases, such as cardiovascular diseases, systemic lupus erythematosus, leukemia, pulmonary tuberculosis, and cancer especially ...
Zhuo-zheng Liang +4 more
semanticscholar +1 more source
Animal Models and Experimental Medicine, EarlyView.The hypothesis diagram illustrates the function and mechanism of circNR3C2: circNR3C2 overexpression can up‐regulate COL2, Aggrecan and SOX9 expression, and regulate chondrogenic differentiation of hADSCs by targeting hsa‐miR‐647. Abstract Background Human adipose‐derived stem cells (hADSCs) are seed cells with application prospects in cartilage repair.
Dabiao Hou +5 more
wiley +1 more source
Performance assessment of total RNA sequencing of human biofluids and extracellular vesicles [PDF]
, 2019 RNA profiling has emerged as a powerful tool to investigate the biomarker potential of human biofluids. However, despite enormous interest in extracellular nucleic acids, RNA sequencing methods to quantify the total RNA content outside cells are rare ...
Anckaert, Jasper +13 more
core +1 more source