Results 141 to 150 of about 52,173 (326)
The hidden regulators: Non‐coding RNAs in KMT2A‐rearranged acute lymphoblastic leukemia
International Journal of Cancer, EarlyView.Abstract Acute lymphoblastic leukemia (ALL) driven by KMT2A rearrangements (KMT2A‐r) is an aggressive hematologic malignancy with poor prognosis and a high incidence in infants. While KMT2A fusion proteins drive leukemogenesis through transcriptional dysregulation, recent discoveries have highlighted the pivotal role of non‐coding RNAs (ncRNAs) in ...
Maria Augusta Poersch +5 more
wiley +1 more source
Programmable biomaterials for dynamic and responsive drug delivery [PDF]
, 2016 Biomaterials are continually being designed that enable new methods for interacting dynamically with cell and tissues, in turn unlocking new capabilities in areas ranging from drug delivery to regenerative medicine. In this review, we explore some of the
Almquist, BD, Kiani, MT, Stejskalova, A
core +1 more source
Prediction of circRNA-disease associations based on inductive matrix completion
BMC Medical Genomics, 2020 Currently, numerous studies indicate that circular RNA (circRNA) is associated with various human complex diseases. While identifying disease-related circRNAs in vivo is time- and labor-consuming, a feasible and effective computational method to predict ...
Menglu Li +3 more
semanticscholar +1 more source
Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials
iNew Medicine, EarlyView.ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong +5 more
wiley +1 more source
Recent advances in malaria genomics and epigenomics [PDF]
, 2016 Malaria continues to impose a significant disease burden on low- and middle-income countries in the tropics. However, revolutionary progress over the last 3 years in nucleic acid sequencing, reverse genetics, and post-genome analyses has generated step ...
Kirchner, Sebastian +2 more
core +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Hepatocellular carcinoma (HCC) is a heterogeneous malignancy characterized by high mortality rates. This article presents a discussion of the role of ZNF652 in HCC cell proliferation and apoptosis, thereby identifying a new target for HCC treatment. The expression levels of ZNF652, circRHOT1, and SLC38A6 in HCC and healthy cells were analyzed.
Kang Chen +7 more
wiley +1 more source
Cancer Management and Research, 2020 Saiyun Lei,1 Lei Xiang2 1Department of Joint Surgical, The Second Affiliated Hospital of University of South China, Hengyang 421001, People’s Republic of China; 2Department of Traumatic Orthopedics, Affiliated Nanhua Hospital, University of South ...
Lei S, Xiang L
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FROM EPIGENETICS TO ANTI-DOPING APPLICATION: A NEW TOOL OF DETECTION [PDF]
, 2017 Eukaryotic genomes transcribe up to 90% of the genomic DNA but only 1\u20132% of these transcripts encode for proteins, whereas the vast majority are transcribed as non-coding RNAs (ncRNAs). They are divided into short ncRNA, particularly microRNA (miRNA)
Cieszczyk, P. +5 more
core +1 more source
circRNA-miRNA-mRNA regulatory network in human lung cancer: an update
Cancer Cell International, 2020 Circular RNAs, as hopeful diagnosis markers and therapeutic molecules, have been studied, probed and applied into several diseases, such as cardiovascular diseases, systemic lupus erythematosus, leukemia, pulmonary tuberculosis, and cancer especially ...
Zhuo-zheng Liang +4 more
semanticscholar +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Triple‐negative breast cancer (TNBC) is characterized as an aggressive malignancy with limited therapeutic options. The circular RNA circ_0006174 has been implicated in oncogenic processes across various cancers; however, its specific role in the pathogenesis of TNBC remains unclear.
Yong‐Zhe Tang +4 more
wiley +1 more source