Results 11 to 20 of about 52,173 (326)
Cancer Management and Research, 2021 Weihong Lin,* Zuopeng Wang,* Jing Wang, Hanlei Yan, Qilei Han, Wei Yao, Kai Li Department of Pediatric Surgery, Children’s Hospital of Fudan University, National Children’s Medical Center, Shanghai, People’s Republic of China*These ...
Lin W +6 more
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Regulation of circRNA biogenesis [PDF]
RNA Biology, 2015 Unlike linear RNAs terminated with 5' caps and 3' tails, circular RNAs are characterized by covalently closed loop structures with neither 5' to 3' polarity nor polyadenylated tail. This intrinsic characteristic has led to the general under-estimation of the existence of circular RNAs in previous polyadenylated transcriptome analyses.
Ling-Ling Chen, Li Yang
semanticscholar +3 more sources
From circRNAs to fusion circRNAs in hematological malignancies [PDF]
JCI Insight, 2021 Circular RNAs (circRNAs) represent a type of endogenous noncoding RNA generated by back-splicing events. Unlike the majority of RNAs, circRNAs are covalently closed, without a 5' end or a 3' poly(A) tail. A few circRNAs can be associated with polysomes, suggesting a protein-coding potential. CircRNAs are not degraded by RNA exonucleases or ribonuclease
Babin, Loelia +5 more
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LncRNAs and CircRNAs in cancer
MedComm, 2022 AbstractIt is well known that noncoding RNAs (ncRNAs) cannot encode proteins, but they can play important regulatory roles in tumors by combining with proteins, RNAs, and DNAs. As more and more studies reveal the important roles and underlying mechanisms of long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) in cancer, their huge application ...
Xin Yin +5 more
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Closing the circle : current state and perspectives of circular RNA databases [PDF]
, 2021 Circular RNAs (circRNAs) are covalently closed RNA molecules that have been linked to various diseases, including cancer. However, a precise function and working mechanism are lacking for the larger majority.
Vandesompele, Jo +2 more
core +1 more source
Circular RNAs in Cervical Cancer: What are the Prospects?
Креативная хирургия и онкология, 2023 C ervical cancer remains a pressing global health problem, creating a significant health burden for women worldwide. High incidence and mortality rates necessitate further research to unravel its underlying molecular mechanisms and identify new ...
S. A. Begliarzade, R. I. Tamrazov
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Unveiling Circular RNA-Mediated Regulatory Mechanisms in Necroptosis in Premature Ovarian Failure
Frontiers in Bioscience-Landmark, 2023 Background: Necroptosis is a programmed necrotic cell death, in which dying cells rupture and release intracellular components that trigger a proinflammatory response.
Xin Jin +6 more
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Exosomal circRNA: emerging insights into cancer progression and clinical application potential
Journal of Hematology & Oncology, 2023 Exosomal circRNA serves a novel genetic information molecule, facilitating communication between tumor cells and microenvironmental cells, such as immune cells, fibroblasts, and other components, thereby regulating critical aspects of cancer progression ...
Fan Zhang +4 more
semanticscholar +1 more source
CircRNA Role and circRNA-Dependent Network (ceRNET) in Asthenozoospermia [PDF]
Frontiers in Endocrinology, 2020 The role of circRNA in reproduction is under investigation. CircRNAs are expressed in human testis, spermatozoa (SPZ), and seminal plasma. Their involvement in embryo development has also been suggested. Asthenozoospermia, a common cause of male infertility, is characterized by reduced or absent sperm motility in fresh ejaculate.
Francesco Manfrevola +8 more
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Identification of a lncRNA/circRNA-miRNA-mRNA ceRNA Network in Alzheimer's Disease
Journal of Integrative Neuroscience, 2023 Background: Alzheimer’s disease (AD) occurs in the elderly and pre-elderly, characterized by decline of memory, cognitive dysfunction, impairment of learning capacity, and motor dysfunction.
Lining Su +3 more
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