Results 11 to 20 of about 45,661 (289)
Cancer Management and Research, 2021 Weihong Lin,* Zuopeng Wang,* Jing Wang, Hanlei Yan, Qilei Han, Wei Yao, Kai Li Department of Pediatric Surgery, Children’s Hospital of Fudan University, National Children’s Medical Center, Shanghai, People’s Republic of China*These ...
Lin W +6 more
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From circRNAs to fusion circRNAs in hematological malignancies [PDF]
JCI Insight, 2021 Circular RNAs (circRNAs) represent a type of endogenous noncoding RNA generated by back-splicing events. Unlike the majority of RNAs, circRNAs are covalently closed, without a 5' end or a 3' poly(A) tail. A few circRNAs can be associated with polysomes, suggesting a protein-coding potential. CircRNAs are not degraded by RNA exonucleases or ribonuclease
Loelia Babin +8 more
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CircRNA May Not Be “Circular” [PDF]
Frontiers in Genetics, 2021 Circular RNA (circRNA) is a novel regulatory non-coding RNA and participates in diverse physiological and pathological processes. However, the structures and molecular mechanisms of circRNAs remain unclear. In this study, taking advantage of openly databases and bioinformatics analysis, we observed lots of internal complementary base-pairing sequences (
Handong Sun +14 more
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Regulation of circRNA biogenesis [PDF]
RNA Biology, 2015 Unlike linear RNAs terminated with 5' caps and 3' tails, circular RNAs are characterized by covalently closed loop structures with neither 5' to 3' polarity nor polyadenylated tail. This intrinsic characteristic has led to the general under-estimation of the existence of circular RNAs in previous polyadenylated transcriptome analyses.
Ling-Ling Chen, Li Yang
semanticscholar +4 more sources
Closing the circle : current state and perspectives of circular RNA databases [PDF]
, 2021 Circular RNAs (circRNAs) are covalently closed RNA molecules that have been linked to various diseases, including cancer. However, a precise function and working mechanism are lacking for the larger majority.
Vandesompele, Jo +2 more
core +1 more source
Exosomal circRNA: emerging insights into cancer progression and clinical application potential
Journal of Hematology & Oncology, 2023 Exosomal circRNA serves a novel genetic information molecule, facilitating communication between tumor cells and microenvironmental cells, such as immune cells, fibroblasts, and other components, thereby regulating critical aspects of cancer progression ...
Fan Zhang +4 more
semanticscholar +1 more source
Signal Transduction and Targeted Therapy, 2023 In this study, we identified that a conserved circular RNA (circRNA) DICAR, which was downregulated in diabetic mouse hearts. DICAR had an inhibitory effect on diabetic cardiomyopathy (DCM), as the spontaneous cardiac dysfunction, cardiac cell ...
Qi Yuan +17 more
semanticscholar +1 more source
Mechanism and Role of circRNA in Occurrence and Development of Hepatocellular Carcinoma
Zhongliu Fangzhi Yanjiu, 2022 Hepatocellular carcinoma (HCC) is the most common pathological type of primary liver cancer, with high fatality rate. The pathogenesis of HCC is complex, and the specific occurrence and development mechanism is still in the exploratory stage.
ZHOU Hong +6 more
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Advancement of science, 2023 Sepsis is one of the most common causes of death, which is closely related to the uncontrolled systemic inflammation. Dysregulation of M1 macrophage polarization is the primary contributor to serious inflammation.
L. Fan +12 more
semanticscholar +1 more source
The potential role and mechanism of circRNA/miRNA axis in cholesterol synthesis
International Journal on Biological Sciences, 2023 Cholesterol levels are an initiating risk factor for atherosclerosis. Many genes play a central role in cholesterol synthesis, including HMGCR, SQLE, HMGCS1, FDFT1, LSS, MVK, PMK, MVD, FDPS, CYP51, TM7SF2, LBR, MSMO1, NSDHL, HSD17B7, DHCR24, EBP, SC5D ...
Wujun Chen +11 more
semanticscholar +1 more source