Results 31 to 40 of about 34,489 (213)

Circular RNAs in Drug-Induced Cardiotoxicity: Roles, Mechanisms, and Therapeutic Potential. [PDF]

J Biochem Mol Toxicol
Circular RNAs have emerged as novel regulators and potential biomarkers in drug‐induced cardiotoxicity. This review summarizes the biogenesis, functional roles, and translational potential of circRNAs in cardiotoxicity assessment and drug safety evaluation.
Leng K, Yang Z, Shi L, Sun Z, Gu M, Tang N.   +5 more
europepmc   +2 more sources

The Promising Role of MicroRNAs, Long Non-Coding RNAs and Circular RNAs in Urological Malignancies [PDF]

Translational Research in Urology, 2022
Nowadays, non-communicable diseases are the leading cause of death worldwide. Cancer management has been a significant challenge for public health in the last decade.
Helia Azodian Ghajar, Roghayeh Koohi Ortakand   +1 more
doaj   +1 more source

Mechanisms of non-coding RNA-modulated alternative splicing in cancer

RNA Biology, 2022
Alternative splicing (AS) is a common and pivotal process for eukaryotic gene expression regulation, which enables a precursor RNA to produce multiple transcript variants with diverse cellular functions.
Xiaolin Wang, Jinghan Hua, Jingxin Li, Jiahui Zhang, Emmanuel Enoch Dzakah, Guozhen Cao, Wenchu Lin   +6 more
doaj   +1 more source

Effect of circular RNA hsa_circ_0000231 interacting with HnRNPK on proliferation, migration, and apoptosis in breast cancer

陆军军医大学学报, 2022
Objective To explore the effects of the interaction between circular RNA hsa_circ_0000231 and HnRNPK on the proliferation, migration and apoptosis in breast cancer. Methods Microarray analysis was used to investigate the expression profile of circRNAs in
HU Mengting, CHEN Junxia
doaj   +1 more source

Research Progress on Non-coding RNAs in Cholesteatoma of the Middle Ear [PDF]

Clinical and Experimental Otorhinolaryngology, 2023
Cholesteatoma of the middle ear is a common disease in otolaryngology that is receiving increasing attention. It is estimated that over five million people around the world have suffered from middle ear cholesteatoma.
Dongliang Liu, Hang Zhang, Xiulan Ma, Yaodong Dong   +3 more
doaj   +1 more source

Overexpression of circRNA and RfxCas13d-mediated circRNA knockdown.

, 2023
(A) Schematic of circRNA-407 overexpression plasmid. Expression of circRNA-407 was driven by AePUb promoter and circularization of LOC109412837 exon 5 to exon 8 was facilitated by Drosophila DNAREP1-DM flanking intron.
Yulan Chen (1788139), Ying Zhou (25031), Jinbao Gu (217536), Peiwen Liu (3518645), Lu Yang (30847), Yonghui Gao (102566), Xiaoguang Chen (187869)   +6 more
core   +1 more source

circRNA-sponging: a pipeline for extensive analysis of circRNA expression and their role in miRNA sponging [PDF]

, 2023
Motivation: Circular RNAs (circRNAs) are long noncoding RNAs (lncRNAs) often associated with diseases and considered potential biomarkers for diagnosis and treatment.
Lee, Hye Kyung, Leon Schwartz, Jakub Jankowski, Markus List, Furth, Priscilla A., Ciora, Octavia Andreea, Octavia-Andreea Ciora, Hennighausen, Lothar, Markus Hoffmann, List, Markus, Baumbach, Jan, Jankowski, Jakub, Lothar Hennighausen, Hoffmann, Markus, Nico Trummer, Lina-Liv Willruth, Jan Baumbach, Priscilla A Furth, Schwartz, Leon, Hye Kyung Lee, Trummer, Nico, Willruth, Lina Liv   +21 more
core   +1 more source

The Recent Research Progress of CircRNA in Bladder Cancer

Annals of Urologic Oncology, 2023
Bladder cancer is a major public health problem in the world, and is one of the most common malignant tumors in the genito-urinary system. Due to its high incidence and mortality, it remains a serious threat to human health.
Shuo Liu, Xin-liang Xu
doaj   +1 more source

IGNSCDA: Predicting CircRNA-Disease Associations Based on Improved Graph Convolutional Network and Negative Sampling.

, 2021
Accumulating evidences have shown that circRNA plays an important role in human diseases. It can be used as potential biomarker for diagnose and treatment of disease.
Wang, J, Lan, W, Liu, J, Chen, Q, Chen, Y-PP, Dong, Y, Chen, YPP, Pan, S, Yi-Ping Phoebe Chen, Jianxin Wang, Yi Dong, Jin Liu, Shirui Pan, Qingfeng Chen, Wei Lan   +14 more
core   +1 more source

circRNA18_46222157_46248185 inhibits melanogenesis by targeting miR-211/ pathway in goat melanocytes [PDF]

Animal Bioscience
Objective This study investigated the effects of circRNA18_46222157_46248185 (named circRNA18) on goat melanogenesis, which differs significantly in goat skins isolated from white and brown coat-colored skins.
Kai Yuan Ji, Xue Qing Zhang, Yi Wei Zhao, Chun E Liang, Xin Yuan, Yun Hai Zhang   +5 more
doaj   +1 more source