Results 11 to 20 of about 28,713 (267)
CircRNA Role and circRNA-Dependent Network (ceRNET) in Asthenozoospermia [PDF]
Frontiers in Endocrinology, 2020 The role of circRNA in reproduction is under investigation. CircRNAs are expressed in human testis, spermatozoa (SPZ), and seminal plasma. Their involvement in embryo development has also been suggested. Asthenozoospermia, a common cause of male infertility, is characterized by reduced or absent sperm motility in fresh ejaculate.
Francesco Manfrevola +8 more
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Cancer Management and Research, 2021 Weihong Lin,* Zuopeng Wang,* Jing Wang, Hanlei Yan, Qilei Han, Wei Yao, Kai Li Department of Pediatric Surgery, Children’s Hospital of Fudan University, National Children’s Medical Center, Shanghai, People’s Republic of China*These ...
Lin W +6 more
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circRNA-sponging: a pipeline for extensive analysis of circRNA expression and their role in miRNA sponging [PDF]
Bioinformatics Advances, 2023 ABSTRACT Motivation Circular RNAs (circRNAs) are long non-coding RNAs (lncRNAs) often associated with diseases and considered potential biomarkers for diagnosis and treatment. Among other functions, circRNAs have been shown to act as microRNA (miRNA) sponges, preventing the role of miRNAs that ...
Markus Hoffmann +10 more
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From circRNAs to fusion circRNAs in hematological malignancies [PDF]
JCI Insight, 2021 Circular RNAs (circRNAs) represent a type of endogenous noncoding RNA generated by back-splicing events. Unlike the majority of RNAs, circRNAs are covalently closed, without a 5' end or a 3' poly(A) tail. A few circRNAs can be associated with polysomes, suggesting a protein-coding potential. CircRNAs are not degraded by RNA exonucleases or ribonuclease
Babin, Loelia +5 more
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CircRNA May Not Be “Circular” [PDF]
Frontiers in Genetics, 2021 Circular RNA (circRNA) is a novel regulatory non-coding RNA and participates in diverse physiological and pathological processes. However, the structures and molecular mechanisms of circRNAs remain unclear. In this study, taking advantage of openly databases and bioinformatics analysis, we observed lots of internal complementary base-pairing sequences (
Handong Sun +14 more
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Circular RNAs in Cervical Cancer: What are the Prospects?
Креативная хирургия и онкология, 2023 C ervical cancer remains a pressing global health problem, creating a significant health burden for women worldwide. High incidence and mortality rates necessitate further research to unravel its underlying molecular mechanisms and identify new ...
S. A. Begliarzade, R. I. Tamrazov
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Unveiling Circular RNA-Mediated Regulatory Mechanisms in Necroptosis in Premature Ovarian Failure
Frontiers in Bioscience-Landmark, 2023 Background: Necroptosis is a programmed necrotic cell death, in which dying cells rupture and release intracellular components that trigger a proinflammatory response.
Xin Jin +6 more
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Identification of a lncRNA/circRNA-miRNA-mRNA ceRNA Network in Alzheimer's Disease
Journal of Integrative Neuroscience, 2023 Background: Alzheimer’s disease (AD) occurs in the elderly and pre-elderly, characterized by decline of memory, cognitive dysfunction, impairment of learning capacity, and motor dysfunction.
Lining Su +3 more
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Molecular Cell, 2017 Circular RNAs (circRNAs) are abundant and evolutionarily conserved RNAs of largely unknown function. Here, we show that a subset of circRNAs is translated in vivo. By performing ribosome footprinting from fly heads, we demonstrate that a group of circRNAs is associated with translating ribosomes.
Pamudurti, Nagarjuna Reddy +16 more
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RNA Biology, 2016 Circular RNAs (circRNAs) are highly abundant and evolutionarily conserved non-coding RNAs produced by circularization of specific exons. Since their re-discovery as potential regulators of gene expression, thousands of circRNAs were detected in different tissues and cell types across most organisms.
Mor, Hanan +2 more
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