Results 11 to 20 of about 34,260 (269)
Cancer Management and Research, 2021 Weihong Lin,* Zuopeng Wang,* Jing Wang, Hanlei Yan, Qilei Han, Wei Yao, Kai Li Department of Pediatric Surgery, Children’s Hospital of Fudan University, National Children’s Medical Center, Shanghai, People’s Republic of China*These ...
Lin W +6 more
doaj +4 more sources
From circRNAs to fusion circRNAs in hematological malignancies [PDF]
JCI Insight, 2021 Circular RNAs (circRNAs) represent a type of endogenous noncoding RNA generated by back-splicing events. Unlike the majority of RNAs, circRNAs are covalently closed, without a 5' end or a 3' poly(A) tail. A few circRNAs can be associated with polysomes, suggesting a protein-coding potential. CircRNAs are not degraded by RNA exonucleases or ribonuclease
Babin, Loelia +5 more
openaire +4 more sources
CircRNA Role and circRNA-Dependent Network (ceRNET) in Asthenozoospermia [PDF]
Frontiers in Endocrinology, 2020 The role of circRNA in reproduction is under investigation. CircRNAs are expressed in human testis, spermatozoa (SPZ), and seminal plasma. Their involvement in embryo development has also been suggested. Asthenozoospermia, a common cause of male infertility, is characterized by reduced or absent sperm motility in fresh ejaculate.
Francesco Manfrevola +8 more
openaire +3 more sources
Molecular Cell, 2017 Circular RNAs (circRNAs) are abundant and evolutionarily conserved RNAs of largely unknown function. Here, we show that a subset of circRNAs is translated in vivo. By performing ribosome footprinting from fly heads, we demonstrate that a group of circRNAs is associated with translating ribosomes.
Pamudurti, Nagarjuna Reddy +16 more
openaire +3 more sources
Closing the circle : current state and perspectives of circular RNA databases [PDF]
, 2021 Circular RNAs (circRNAs) are covalently closed RNA molecules that have been linked to various diseases, including cancer. However, a precise function and working mechanism are lacking for the larger majority.
Vandesompele, Jo +2 more
core +1 more source
CircRNA May Not Be “Circular” [PDF]
Frontiers in Genetics, 2021 Circular RNA (circRNA) is a novel regulatory non-coding RNA and participates in diverse physiological and pathological processes. However, the structures and molecular mechanisms of circRNAs remain unclear. In this study, taking advantage of openly databases and bioinformatics analysis, we observed lots of internal complementary base-pairing sequences (
Handong Sun +14 more
openaire +3 more sources
Current Opinion in Genetics & Development, 2018 Exonic circular RNAs (circRNAs) are mostly generated from exons of protein-coding genes and, in many cases, are more abundant that the linear product from their hosting gene. Certain circRNAs are very abundant in the brain and in non-dividing cells; and many also show physiological-specific and tissue-specific expression.
Patop, Ines Lucia, Kadener, Sebastian
openaire +2 more sources
CircRNA expression profile and circRNA-miRNA-mRNA crosstalk in allergic rhinitis [PDF]
World Allergy Organization Journal, 2020 Circular RNAs (circRNAs) are involved in inflammation; however, their role in allergic rhinitis (AR) remains unclear. In this study, we analyzed circRNA expression and identified a circRNA-miRNA-mRNA network through which circRNAs regulate AR pathogenesis.We analyzed circRNA, miRNA, and mRNA expression profiles in the nasal mucosa by high-throughput ...
Chang-Yu Qiu +7 more
openaire +3 more sources
Nature Reviews Molecular Cell Biology, 2020 Increased expression of the circular RNA generated by the sulfateless gene (circSfl), and of the protein it encodes, can extend the lifespan of flies.
openaire +2 more sources
NOVA2 regulates neural circRNA biogenesis [PDF]
Nucleic Acids Research, 2021 Abstract Circular RNAs (circRNAs) are highly expressed in the brain and their expression increases during neuronal differentiation. The factors regulating circRNAs in the developing mouse brain are unknown. NOVA1 and NOVA2 are neural-enriched RNA-binding proteins with well-characterized roles in alternative splicing.
David Knupp +4 more
openaire +3 more sources