Results 21 to 30 of about 52,173 (326)
Signal Transduction and Targeted Therapy, 2023 In this study, we identified that a conserved circular RNA (circRNA) DICAR, which was downregulated in diabetic mouse hearts. DICAR had an inhibitory effect on diabetic cardiomyopathy (DCM), as the spontaneous cardiac dysfunction, cardiac cell ...
Qi Yuan +17 more
semanticscholar +1 more source
Research Progress on Non-coding RNAs in Cholesteatoma of the Middle Ear [PDF]
Clinical and Experimental Otorhinolaryngology, 2023 Cholesteatoma of the middle ear is a common disease in otolaryngology that is receiving increasing attention. It is estimated that over five million people around the world have suffered from middle ear cholesteatoma.
Dongliang Liu +3 more
doaj +1 more source
Molecular Cell, 2017 Circular RNAs (circRNAs) are abundant and evolutionarily conserved RNAs of largely unknown function. Here, we show that a subset of circRNAs is translated in vivo. By performing ribosome footprinting from fly heads, we demonstrate that a group of circRNAs is associated with translating ribosomes.
Pamudurti, Nagarjuna Reddy +16 more
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The roles of circRNA–miRNA–mRNA networks in the development and treatment of osteoporosis [PDF]
Frontiers in Endocrinology, 2022 Osteoporosis is a systemic metabolic disease, mainly characterized by reduced bone mineral density and destruction of bone tissue microstructure. However, the molecular mechanisms of osteoporosis need further investigation and exploration.
Manqi Gao +4 more
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Advancement of science, 2023 Sepsis is one of the most common causes of death, which is closely related to the uncontrolled systemic inflammation. Dysregulation of M1 macrophage polarization is the primary contributor to serious inflammation.
L. Fan +12 more
semanticscholar +1 more source
CircRNA May Not Be “Circular” [PDF]
Frontiers in Genetics, 2021 Circular RNA (circRNA) is a novel regulatory non-coding RNA and participates in diverse physiological and pathological processes. However, the structures and molecular mechanisms of circRNAs remain unclear. In this study, taking advantage of openly databases and bioinformatics analysis, we observed lots of internal complementary base-pairing sequences (
Handong Sun +14 more
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陆军军医大学学报, 2023 Objective To investigate the effects of intraperitoneal injection of islet amyloid polypeptide (IAPP) on the expression profiles of circular RNAs (circRNAs) and messenger RNAs (mRNAs) in the brain tissue of Alzheimer's disease (AD) mice and wild-type ...
HOU Mingliang +3 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2023 Significance Metastasis is responsible for most of cancer-related deaths, which requires dramatic remodeling of the cytoskeleton. Circular RNA ASH2 (circASH2) functions as a powerful tumor suppressor via directly modulating stability of microfilament ...
Boqiang Liu +15 more
semanticscholar +1 more source
The potential role and mechanism of circRNA/miRNA axis in cholesterol synthesis
International Journal on Biological Sciences, 2023 Cholesterol levels are an initiating risk factor for atherosclerosis. Many genes play a central role in cholesterol synthesis, including HMGCR, SQLE, HMGCS1, FDFT1, LSS, MVK, PMK, MVD, FDPS, CYP51, TM7SF2, LBR, MSMO1, NSDHL, HSD17B7, DHCR24, EBP, SC5D ...
Wujun Chen +11 more
semanticscholar +1 more source
Current Opinion in Genetics & Development, 2018 Exonic circular RNAs (circRNAs) are mostly generated from exons of protein-coding genes and, in many cases, are more abundant that the linear product from their hosting gene. Certain circRNAs are very abundant in the brain and in non-dividing cells; and many also show physiological-specific and tissue-specific expression.
Patop, Ines Lucia, Kadener, Sebastian
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