Results 51 to 60 of about 385,110 (187)

Interleukin-10 modulates the synthesis of inflammatory mediators in the sensory circumventricular organs: implications for the regulation of fever and sickness behaviors. [PDF]

J Neuroinflammation, 2013
Background Whereas the role played by interleukin (IL)-10 in modulating fever and sickness behavior has been linked to it targeting the production of pro-inflammatory cytokines in the circulation, liver and spleen, it is not known whether it could ...
Harden LM, Rummel C, Luheshi GN, Poole S, Gerstberger R, Roth J.   +5 more
europepmc   +3 more sources

Origin and development of circumventricular organs in living vertebrate

Seminars in Cell & Developmental Biology, 2020
The circumventricular organs (CVOs) function by mediating chemical communication between blood and brain across the blood-brain barrier. Their origin and developmental mechanisms involved are not understood in enough detail due to a lack of molecular markers common for CVOs. These rather small and inconspicuous organs are found in close vicinity to the
Vladimir, Korzh, Igor, Kondrychyn
openaire   +2 more sources

GLP‐1 receptor agonists in Alzheimer's disease and MCI: a meta‐analysis

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 4, October/December 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) is the leading cause of dementia in older individuals and remains a major clinical and socioeconomic burden. Despite the success of anti‐amyloid therapies in reducing biomarker burden, more effective and safer treatments are still needed.
Ryan G. P. Siqueira, Carlotta Ranalli, Duygu Yılmaz, Meire da Silva, Bernardo Raposo Pinel Maltez, Giovanni Gosch Berton, Jeffrey L. Cummings   +6 more
wiley   +1 more source

Effect of neonatal monosodium glutamate on the activities of glutamate dehydrogenase and aminotransferases in the circumventricular organs of rat brain

, 1995
Glutamate (Glu) the major amino acid in mammalian brain and most dietary proteins possesses neurotransmitter as well as neurotoxic properties. We administered monosodium glutamate (MSG) 4 mg/g bwt, sc on postnatal day (PND) 1 through 10 to rats on ...
Ali, M. M., Babu, G. Nagesh, Misra, U. K., Bawari, M.   +3 more
core   +1 more source

The expression pattern of the Na+ sensor, NaX in the hydromineral homeostatic network: a comparative study between the rat and mouse

Frontiers in Neuroanatomy, 2012
The Scn7a gene encodes for the specific sodium channel NaX, which is considered a primary determinant of sodium sensing in the brain. Only partial data exist describing the NaX distribution pattern and the cell types that express NaX in both the rat and ...
Benjamin eNehmé, Mélaine eHenry, Didier eMouginot, Didier eMouginot   +3 more
doaj   +1 more source

Whole‐Brain Monosynaptic Inputs and Outputs of Corticotropin‐Releasing Hormone Neurons of the Paraventricular Nucleus of the Hypothalamus in Male Mice

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Using rabies‐based monosynaptic retrograde tracing and AAV anterograde labeling, this study maps the brain‐wide inputs and outputs of PVN CRH neurons, identifying them as a key hub coordinating stress, autonomic, and behavioral responses. ABSTRACT Objective The paraventricular nucleus of the hypothalamus (PVN) is a central hub integrating ...
Ziteng Yue, Danyang Zhao, Xinxin Chen, Yousheng Zhang, Heng Zhang, Yinchang Wang, Yuhang Liu, Yuxin Yang, Can Geng, Yimeng Song, Xiaoyi Wang, Sheng Wang   +11 more
wiley   +1 more source

Cancer Neuroscience: From Local Neuro–Immune Microenvironments to Systemic Brain–Body Circuitry

MedComm, Volume 7, Issue 9, September 2026.
This review outlines the cancer neuroscience paradigm, spanning systemic brain–body circuitry and local neuro–immune–tumor microenvironments. We discuss how tumors promote axonogenesis and pseudo‐synapse formation, and how sensory neuropeptides, such as CGRP, contribute to CD8+ T‐cell exhaustion.
Mingxuan Xie, Yu Zhao, Xinruo Xing, Yuqiang Liu, Jungang Zhao, Maojin Yao, Jun Tang, Jianzhu Zhao   +7 more
wiley   +1 more source

Effects of extremely low frequency electromagnetic fields on vascular permeability of circumventricular organs in the adult rat

, 2008
The present work deals with the effects of extremely low frequency electromagnetic fields (ELF-EMF) on blood vessels permeability to non liposoluble substances of the circumventricular organs (CVO) of adult rats.
Gutierrez-Mercado, Y.K., Serrano-Luna, G., Feria-Velasco, A., Canedo-Dorantes, L., Banuelos-Pineda, J.   +4 more
core   +1 more source

Circumventricular Organ Apelin Receptor Knockdown Decreases Blood Pressure and Sympathetic Drive Responses in the Spontaneously Hypertensive Rat

Frontiers in Physiology, 2021
The central site(s) mediating the cardiovascular actions of the apelin-apelin receptor (APJ) system remains a major question. We hypothesized that the sensory circumventricular organs (CVOs), interfacing between the circulation and deeper brain ...
Philip R. Griffiths, Stephen J. Lolait, Julian F. R. Paton, Julian F. R. Paton, Anne-Marie O’Carroll   +4 more
doaj   +1 more source

A symmetric systemic challenge elicits a right‐biased response mediated by vasopressin signaling

Journal of Neuroendocrinology, Volume 38, Issue 9, September 2026.
Water deprivation, a spatially symmetric homeostatic challenge, induces vasopressin receptor‐dependent right‐sided hindlimb asymmetry in rats, providing a binary readout of lateralized physiological regulation. These findings suggest that symmetric homeostatic challenges can engage neuroendocrine mechanisms that shift the balance between left‐ and ...
Hiroyuki Watanabe, Yaromir Kobikov, Sara Yusuf Mohamed, Karen Rich, Daniil Sarkisyan, Olga Nosova, Alfhild Grönbladh, Mathias Hallberg, Jens Schouenborg, Georgy Bakalkin, Mengliang Zhang   +10 more
wiley   +1 more source