Results 51 to 60 of about 4,605 (161)

GLP‐1 at the Metabolic–Cognitive Interface: Reward, Affect, and Memory

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
GLP‐1R signaling integrates metabolic state with neural circuits controlling reward, mood, and memory, acting as a metabolic‐cognitive interface. In reward pathways, it suppresses hedonic feeding and drug seeking; in affective circuits, sustained signaling promotes anxiolytic and antidepressant effects; and in the hippocampus, it enhances synaptic ...
Serena X. Gao, Léa Décarie‐Spain, Cindy Gu, Giulia Mazzini, Scott E. Kanoski, Tito Borner   +5 more
wiley   +1 more source

Targeting Multiple Gut‐Brain Pathways in Obesity: Rationale for Combination Pharmacotherapy

Obesity Science &Practice, Volume 12, Issue 2, April 2026.
ABSTRACT Background As a disease of energy dysregulation, obesity involves metabolic, hormonal, and neural factors, the interconnection of which is referred to as the “gut‐brain axis.” Objective This review aimed to provide an overview of the clinical evidence of physiological and objective or subjective changes in eating behavior with gut hormone ...
Alexander D. Miras, Muzamil Hussain
wiley   +1 more source

AT1R in Central Nervous System Disorders: Unveiling Novel Mechanisms and Therapeutic Avenues for Addiction

Addiction Biology, Volume 31, Issue 4, April 2026.
AT1R signaling drives addiction through interconnected pathways, and AT1R antagonists target multiple nodes for therapeutic effects. ABSTRACT Although the angiotensin II type 1 receptor (AT1R), a pivotal component of the renin–angiotensin system (RAS), is associated with cardiovascular and renal homeostasis, burgeoning evidence implicates its critical ...
Jianan Lv, Dan Zhu, Sisi Song, Jiahui Zhou, Xiaoyu Zhang, Wenhua Zhou, Yu Liu, Zizhen Si   +7 more
wiley   +1 more source

Is headache always necessary for the diagnosis of rebound intracranial hypertension in patients successfully treated for cerebrospinal fluid venous fistula?

Headache: The Journal of Head and Face Pain, Volume 66, Issue 6, Page 1386-1389, June 2026.
Rayyan Kinsara, Anish Kapadia, Howard Meng   +2 more
wiley   +1 more source

Signal Amplification in the HPT Axis—Evidence for Its Existence, Location, Significance, and Molecular Mechanisms

Acta Physiologica, Volume 242, Issue 4, April 2026.
ABSTRACT Thyroid hormones (THs) are under negative feedback regulation via the hypothalamic–pituitary‐thyroid (HPT) axis. How this axis operates to keep the circulating THs within a narrow physiological range is not well understood quantitatively. Led by the design principle of robust homeostatic feedback control, here we review and synthesize the ...
Li Jing, Sarahna A. Moyd, Qiang Zhang
wiley   +1 more source

Low wnt/β-catenin signaling determines leaky vessels in the subfornical organ and affects water homeostasis in mice

eLife, 2019
The circumventricular organs (CVOs) in the central nervous system (CNS) lack a vascular blood-brain barrier (BBB), creating communication sites for sensory or secretory neurons, involved in body homeostasis.
Fabienne Benz, Viraya Wichitnaowarat, Martin Lehmann, Raoul FV Germano, Diana Mihova, Jadranka Macas, Ralf H Adams, M Mark Taketo, Karl-Heinz Plate, Sylvaine Guérit, Benoit Vanhollebeke, Stefan Liebner   +11 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, Volume 600, Issue 5, Page 591-611, March 2026.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Ouabain‐induced hypertension in rats: Mechanisms, variability and translational implications

Experimental Physiology, Volume 111, Issue 3, Page 653-673, 1 March 2026.
Abstract Ouabain‐induced hypertension is a multifactorial and condition‐dependent phenomenon involving coordinated actions across vascular, renal and central nervous system pathways. At the vascular level, ouabain inhibits Na⁺/K⁺‐ATPase, particularly the α2‐isoform, leading to elevated intracellular Ca2⁺, enhanced vasoconstriction and structural ...
Priscilla Rodrigues O. Feijó, Luis Eduardo M. Quintas   +1 more
wiley   +1 more source

The Circumventricular Organs

Circumventricular organs (CVOs) are highly vascularized midline structures lacking a complete blood-brain barrier (BBB) due to the presence of fenestrated vasculature, allowing peripheral circulating factors to penetrate the brain and influence neuronal activity.
Armocida, Daniele, Pesce, Alessandro, Paternò, Giovanni, Palmieri, Mauro, Salvati, Maurizio, Ascenzi, Brandon M., Frati, Alessandro   +6 more
openaire   +2 more sources

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo, Hui Liu, Yu‐Jing Song, Jian‐Hua Wang, Danfeng Liu, Zhi‐Wei Zheng, Jia‐Jun Li, Boya Li, An Song, Wei He, Lei‐Lei Yang, Shuo Wang   +11 more
wiley   +1 more source