Results 61 to 70 of about 385,110 (187)

Ascending and descending networks involving the NTS and other structures associated with large-scale choline & amine projection systems and the circumventricular organs.

, 2023
Sagittal and horizontal schematic brain drawings are shown with ascending (green) and descending (red) networks involving the NTS. Reciprocal networks extending from the telencephalon to the spinal cord involve cholinergic (Ch) and aminergic (A, B, C, H:
Yoshinori Kawai (16792753)
core   +1 more source

Selective distribution of GLUT3-expressing nerve fibers in the lamina terminails among the circumventricular organs of mice

, 2019
Sensory circumventricular organs contain the subfornical organ, organum vasculosum of the lamina terminalis (OVLT), and area postrema. Here, immunostaining for GLUT3 in the murine brain selectively labeled the sobfornical organ and OVLT.
Iwanaga, Toshihiko, Konno, Kohtarou, Watanabe, Masahiko   +2 more
core   +1 more source

Unraveling the Inflammatory Enigma: Is Neuroinflammation a Culprit or Consequence in Pharmacoresistant Epilepsy?

Brain and Behavior, Volume 16, Issue 8, August 2026.
ABSTRACT Background Approximately 30% of epilepsy patients develop pharmacoresistant epilepsy (PRE), characterized by persistent seizures refractory to antiseizure medications (ASMs). While neuroinflammation is implicated in both epileptogenesis and treatment failure, its precise temporal contribution remains unclear.
Xianmei Wang, Jie Deng, Dai Shi, Zhiyan Liu, Likun Wang, Guofeng Wu   +5 more
wiley   +1 more source

The Circumventricular Organs

Circumventricular organs (CVOs) are highly vascularized midline structures lacking a complete blood-brain barrier (BBB) due to the presence of fenestrated vasculature, allowing peripheral circulating factors to penetrate the brain and influence neuronal activity.
Armocida, Daniele, Pesce, Alessandro, Paternò, Giovanni, Palmieri, Mauro, Salvati, Maurizio, Ascenzi, Brandon M., Frati, Alessandro   +6 more
openaire   +2 more sources

The Neuroprotective Potentials of Dual GIP/GLP1‐RA (Tirzepatide): From Preclinical Experiments to Clinical Trials: A Scoping Review

Brain and Behavior, Volume 16, Issue 8, August 2026.
The graphical abstract summarizes the current evidence on the potential neuroprotective effects of tirzepatide (TZP), a dual GIP/GLP‐1 receptor agonist, across mechanistic, preclinical, and clinical domains. Mechanistically, TZP is proposed to exert direct neural effects, preserve mitochondrial function, reduce apoptosis, oxidative stress, and ...
Yousef Hawas, Mohamed Abouzid, Ahmed Farid Gadelmawla, Dalia Kamal Ewis, Abdallah Khatatbeh, Yasmin Negida, Ahmed Negida   +6 more
wiley   +1 more source

Distribution of GLP-I binding sites in the rat brain: evidence that Exendin-4 is a ligand of brain DLP-1 binding sites

, 1995
Gut-brain-axis, circumventricular organs, receptor ...
Göke, R., Sheikh, Søren P., Mikkelsen, J.D., Larsen, P.J.   +3 more
core   +1 more source

Sustained microglial activation in the area postrema of collagen-induced arthritis mice

Arthritis Research & Therapy, 2021
Background Central nervous system (CNS)-mediated symptoms, such as fatigue, depression, and hyperalgesia, are common complications among patients with rheumatoid arthritis (RA).
Takayuki Matsushita, Kazuhiro Otani, Yohsuke Oto, Yukari Takahashi, Daitaro Kurosaka, Fusao Kato   +5 more
doaj   +1 more source

Microbiome‐Phytochemical Crosstalk Along the Gut‐Brain Axis in Alzheimer and Parkinson's Disease

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Phytochemicals remodel the gut microbiota by enriching beneficial bacteria and microbial metabolites while suppressing dysbiosis and inflammation. Through modulation of the gut–brain axis, they restore intestinal barrier integrity, regulate neuroimmune and neuroprotective signaling pathways, reduce amyloid‐β, tau, and α‐synuclein pathology, and ...
Md. Emon, Md. Mizanur Rahaman, Dhrubo Sarder, Md. Shadin, Shamima Akter Neela, Phurpa Wangchuk, Subir Sarker   +6 more
wiley   +1 more source

Lactate dehydrogenase and glutamate dehydrogenase activities in the circumventricular organs of rat brain following neonatal monosodium glutamate

, 1993
Glutamate (glu) an excitatory neurotransmitter amino acid, is present in high concentrations in the mammalian central nervous system and is the most abundant amino acid in our daily diet. In the present study the activities of lactate dehydrogenase (LDH)
Ali, M. M., Babu, G. N., Chandra, S. V., Misra, U. K., Bawari, M.   +4 more
core   +1 more source

Correlation of blood-brain barrier function and HT7 protein distribution in chick brain circumventricular organs

, 1990
The HT7 protein defined by a monoclonal antibody is a specific marker for chick brain endothelial cells (EMBO J., 5 (1986) 3179-3183). In this study, we have investigated the expression of this protein in the brain circumventricular organs which lack a ...
Schwarz, H., Riesau, W., Seulberger, H., Albrecht, U.   +3 more
core   +1 more source