Presence and reactivities of antibodies directed to citrullinated peptides in a Swedish JIA cohort [PDF]
Pediatric Rheumatology Online JournalBackground Juvenile idiopathic arthritis is a heterogeneous group of chronic inflammatory joint diseases in children. The presence and role of antibodies targeting citrullinated proteins remains unclear in this patient group.
Raya Saleh +8 more
doaj +2 more sources
Both Systemic and Intra-articular Immunization with Citrullinated Peptides Are Needed to Induce Arthritis in the Macaque [PDF]
Frontiers in Immunology, 2017 ObjectivesAnti-citrullinated peptides antibodies (ACPAs) have high specificity for the diagnosis of rheumatoid arthritis (RA), but their role in the pathophysiology is not fully established.
Samuel Bitoun +10 more
doaj +2 more sources
Citrullinated peptides of peptidyl arginine deiminase 4 as major B-cell epitopes in patients with rheumatoid arthritis [PDF]
Frontiers in ImmunologyObjectiveTo identify new autoantibodies in rheumatoid arthritis (RA) patients’ sera.MethodsWe tested serum samples from 55 patients with RA and 25 controls on arrays containing 188 peptides from the alpha and beta chains of fibrinogen, vimentin, histon 4,
Mathilde Giassi +4 more
doaj +2 more sources
Citrullinated peptides as drug candidates for rheumatoid arthritis [PDF]
Frontiers in ImmunologyRheumatoid arthritis (RA) involves a breakdown of immune tolerance to citrullinated proteins, leading to chronic inflammation and joint damage. Despite advances in treatment, achieving long-term remission remains a major challenge.
Adrian H. Bustos +5 more
doaj +2 more sources
Are antibodies to fine specificities of citrullinated peptides/proteins useful for stratification of rheumatoid arthritis patients? [PDF]
Clinical & Translational Immunology, 2021 Background In rheumatoid arthritis (RA), antibodies to citrullinated protein (ACPA) are believed to be heterogeneous and patient stratification by antibody profiling raised clinical interest for patient management.
Leonor Nogueira +4 more
doaj +2 more sources
Development of a multiplex assay based on chimeric citrullinated peptides as proof of concept for diagnosis of rheumatoid arthritis. [PDF]
PLoS ONE, 2019 Anti-citrullinated peptide/protein antibodies (ACPAs) are the most specific serological biomarkers for rheumatoid arthritis (RA). They have both diagnostic and prognostic value, and are related to more aggressive joint disease in RA.
Cristina García-Moreno +4 more
doaj +2 more sources
Antibodies to citrullinated peptides are not associated with the rate of joint destruction in patients with a well-established diagnosis of rheumatoid arthritis [PDF]
Brazilian Journal of Medical and Biological Research, 2008 Antibodies to citrullinated peptides are highly specific for rheumatoid arthritis (RA) and represent a significant risk factor for undifferentiated polyarthritis.
A.M. Nieto-Colonia +5 more
doaj +3 more sources
Characterization and Localization of Citrullinated Proteoglycan Aggrecan in Human Articular Cartilage. [PDF]
PLoS ONE, 2016 BackgroundRheumatoid arthritis (RA) is an autoimmune disease of the synovial joints. The autoimmune character of RA is underscored by prominent production of autoantibodies such as those against IgG (rheumatoid factor), and a broad array of joint tissue ...
Tibor T Glant +6 more
doaj +3 more sources
Antibodies, 2022 Rheumatoid arthritis (RA) is a chronic disease which causes joint inflammation and, ultimately, erosion of the underlying bone. Diagnosis of RA is based on the presence of biomarkers, such as anti-citrullinated protein antibodies (ACPA) and rheumatoid ...
Ilaria Fanelli +5 more
doaj +1 more source
PLoS ONE, 2022 The immune response to citrullinated peptides in the mucosa has been suggested to play an important role in the transition from pre-onset rheumatoid arthritis (RA) to clinically evident RA.
Takuya Yasuda +2 more
doaj +2 more sources