Results 11 to 20 of about 12,205 (240)

Autophagy generates citrullinated peptides in human synoviocytes: a possible trigger for anti-citrullinated peptide antibodies [PDF]

Rheumatology, 2016
OBJECTIVES: Autophagy may represent a functional processing event that creates a substrate for autoreactivity. In particular, autophagy may play a role in the pathogenesis of RA, since autophagy is a key cellular event involved in the generation of ...
Alessandra Nerviani, Antonella Capozzi, Cristiano Alessandri, Cristina Iannuccelli, Emanuela Lococo, Guido Valesini, Kato, Manuela Di Franco, Maurizio Sorice, Michele Bombardieri, Neumann, Pickl, Roberta Misasi, Tina Garofalo, Valeria Manganelli   +14 more
core   +4 more sources

Contribution of Peptide Backbone to Anti-Citrullinated Peptide Antibody Reactivity.

PLoS ONE, 2015
Rheumatoid arthritis (RA) is one of the most common autoimmune diseases, affecting approximately 1-2% of the world population. One of the characteristic features of RA is the presence of autoantibodies.
Nicole Hartwig Trier, Catharina Essendrup Dam, Dorthe Tange Olsen, Paul Robert Hansen, Gunnar Houen   +4 more
doaj   +4 more sources

How RA Associated HLA-DR Molecules Contribute to the Development of Antibodies to Citrullinated Proteins: The Hapten Carrier Model

Frontiers in Immunology, 2022
The risk to develop ACPA positive rheumatoid arthritis (RA), the most destructive type of autoimmune arthritis, is carried by HLA-DRB1 alleles containing a 5 amino acid motif: the shared epitope (SE).
Jean Roudier, Jean Roudier, Jean Roudier, Nathalie Balandraud, Nathalie Balandraud, Isabelle Auger, Isabelle Auger   +6 more
doaj   +1 more source

Citrullinated Epitopes Identified on Tumour MHC Class II by Peptide Elution Stimulate Both Regulatory and Th1 Responses and Require Careful Selection for Optimal Anti-Tumour Responses

Frontiers in Immunology, 2021
BackgroundSomatic mutations or post-translational modifications of proteins result in changes that enable immune recognition. One such post-translational modification is citrullination, the conversion of arginine residues to citrulline.
Peter Symonds, Ana Marcu, Ana Marcu, Katherine W. Cook, Rachael L. Metheringham, Lindy G. Durrant, Lindy G. Durrant, Victoria A. Brentville   +7 more
doaj   +1 more source

Specificity of Anti-Citrullinated Protein Antibodies to Citrullinated α-Enolase Peptides as a Function of Epitope Structure and Composition

Antibodies, 2021
Rheumatoid arthritis (RA) is an autoimmune disease affecting approximately 1–2% of the world population. In addition to the first discovered serologic markers for RA, the rheumatoid factors (RFs), anti-citrullinated protein antibodies (ACPAs) are even ...
Ilaria Fanelli, Paolo Rovero, Paul Robert Hansen, Jette Frederiksen, Gunnar Houen, Nicole Hartwig Trier   +5 more
doaj   +1 more source

Antibodies to citrullinated peptides in tuberculosis [PDF]

Clinical Rheumatology, 2013
Rheumatoid arthritis (RA) is an autoimmune disease characterized by symmetric polyarthritis, rheumatoid factor (RF) positivity, and bone erosions. Recently, research has been conducted on anti-citrullinated peptide antibodies (ACPAs) to which there are greater sensitivity and specificity than RF.
I, Lima, R C, Oliveira, A, Atta, S, Marchi, L, Barbosa, E, Reis, M G, Reis, M B, Santiago   +7 more
openaire   +2 more sources

The role of posttranslational modifications in generating neo-epitopes that bind to rheumatoid arthritis-associated HLA-DR alleles and promote autoimmune T cell responses.

PLoS ONE, 2021
While antibodies to citrullinated proteins have become a diagnostic hallmark in rheumatoid arthritis (RA), we still do not understand how the autoimmune T cell response is influenced by these citrullinated proteins.
Stephane Becart, Karen B Whittington, Amanda Prislovsky, Navin L Rao, Edward F Rosloniec   +4 more
doaj   +1 more source

Collision-Induced Dissociation of Citrullinated Peptide Anions

Journal of the American Society for Mass Spectrometry, 2023
Peptide identification by positive electrospray ionization (ES+) tandem mass spectrometry (MS/MS) is a well-established strategy in proteomics. Several research groups reported the usefulness of negative electrospray ionization (ES-) for gaining complementary structural information on peptides and their post-translational modifications (PTM) compared ...
Arnold Steckel, Dávid Papp, Katalin Uray, Gitta Schlosser   +3 more
openaire   +2 more sources

PAD4 Immunization Triggers Anti-Citrullinated Peptide Antibodies in Normal Mice: Analysis With Peptide Arrays

Frontiers in Immunology, 2022
The critical immunological event in rheumatoid arthritis (RA) is the production of antibodies to citrullinated proteins (ACPAs), ie proteins on which arginines have been transformed into citrullines by peptidyl arginine deiminases (PAD).
Marie F. Hemon, Marie F. Hemon, Nathalie C. Lambert, Fanny Arnoux, Jean Roudier, Jean Roudier, Isabelle Auger   +6 more
doaj   +1 more source

Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis [PDF]

, 2009
Antibodies to citrulline-modifi ed proteins have a high diagnostic value in rheumatoid arthritis (RA). However, their biological role in disease development is still unclear.
Aho, Andersson, Auger, Baeten, Bella, Bettina Sehnert, Brunsberg, Burkhardt, Burkhardt, Bäcklund, Caspi, Chang, Chapuy-Regaud, Collaborative Computational Project, Number 4, DeLano, Dyson, Emsley, Emsley, Emsley, Estelle Bajtner, Foulquier, Girbal-Neuhauser, Giudicelli, Grab, Guy Serre, Harald Burkhardt, Hill, Hill, Hoffmann, Hüseyin Uysal, Kabsch, Kanazawa, Kidd, Krissinel, Kuhn, Kutty S. Nandakumar, Lefranc, Marjolein M.G.M. Thunnissen, Masson-Bessière, Masson-Bessière, Michaëlsson, Molberg, Murshudov, Nair, Nandakumar, Rantapää-Dahlqvist, Read, Reparon-Schuijt, Rikard Holmdahl, Robert Bockermann, Rosloniec, Schellekens, Schellekens, Schulte, Schwab, Stanfield, Stetefeld, Tarcsa, Uysal, van der Helm-van Mil, Vander Cruyssen, von Delwig, Vossenaar, Vossenaar, Vossenaar, Vossenaar, Winn, Yousfi Monod, Zong, Åke Engström   +69 more
core   +2 more sources