Results 1 to 10 of about 14,198 (253)

Histone citrullination: a new target for tumors

Molecular Cancer, 2021
As the main protein components of chromatin, histones play central roles in gene regulation as spools of winding DNA. Histones are subject to various modifications, including phosphorylation, acetylation, glycosylation, methylation, ubiquitination and ...
Dongwei Zhu, Yue Zhang, Shengjun Wang
doaj   +2 more sources

Novel method to quantify peptidylarginine deiminase activity shows distinct citrullination patterns in rheumatoid and juvenile idiopathic arthritis

Frontiers in Immunology, 2023
IntroductionPeptidylarginine deiminases (PADs) mediate citrullination, an irreversible posttranslational modification that converts arginine to citrulline residues in proteins.
Karen Yu, Luna Dillemans, Mieke Gouwy, Helena Bessa, Mieke Metzemaekers, Erik Martens, Patrick Matthys, Xavier Bossuyt, Patrick Verschueren, Carine Wouters, Lien De Somer, Paul Proost   +11 more
doaj   +2 more sources

Citrullination Post-Translational Modification: State of the Art of Brain Tumor Investigations and Future Perspectives

Diagnostics, 2023
The present review aims to describe the state of the art of research studies investigating the citrullination post-translational modification in adult and pediatric brain tumors.
Diana Valeria Rossetti, Alexandra Muntiu, Luca Massimi, Gianpiero Tamburrini, Claudia Desiderio   +4 more
doaj   +2 more sources

SMARCAD1 Contributes to the Regulation of Naive Pluripotency by Interacting with Histone Citrullination [PDF]

Cell Reports, 2017
Histone citrullination regulates diverse cellular processes. Here, we report that SMARCAD1 preferentially associates with H3 arginine 26 citrullination (H3R26Cit) peptides present on arrays composed of 384 histone peptides harboring distinct post ...
Shu Xiao, Jia Lu, Bharat Sridhar, Xiaoyi Cao, Pengfei Yu, Tianyi Zhao, Chieh-Chun Chen, Darina McDee, Laura Sloofman, Yang Wang, Marcelo Rivas-Astroza, Bhanu Prakash V.L. Telugu, Dana Levasseur, Kang Zhang, Han Liang, Jing Crystal Zhao, Tetsuya S. Tanaka, Gary Stormo, Sheng Zhong   +18 more
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Cholinergic dysfunction-induced insufficient activation of alpha7 nicotinic acetylcholine receptor drives the development of rheumatoid arthritis through promoting protein citrullination via the SP3/PAD4 pathway

Acta Pharmaceutica Sinica B, 2023
Both cholinergic dysfunction and protein citrullination are the hallmarks of rheumatoid arthritis (RA), but the relationship between the two phenomena remains unclear. We explored whether and how cholinergic dysfunction accelerates protein citrullination
Changjun Lv, Minghui Sun, Yilei Guo, Wenxin Xia, Simiao Qiao, Yu Tao, Yulai Fang, Qin Zhang, Yanrong Zhu, Yusufu Yalikun, Yufeng Xia, Zhifeng Wei, Yue Dai   +12 more
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The Citrullination-Neutrophil Extracellular Trap Axis in Chronic Diseases

Journal of Innate Immunity, 2022
Citrullination of proteins is crucial for the formation of neutrophil extracellular traps (NETs) – strands of nuclear DNA expulsed in the extracellular environment along with antimicrobial proteins in order to halt the spread of pathogens. Paradoxically,
Martin Maronek, Roman Gardlik
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Inflammation-related citrullination of matrisome proteins in human cancer

Frontiers in Oncology, 2022
IntroductionProtein arginine deiminases (PADs) are intracellular enzymes that may, especially in pathological conditions, also citrullinate extracellular substrates, including matrisome proteins such as structural proteins in extracellular matrix (ECM ...
Pekka Rappu, Ujjwal Suwal, Elina Siljamäki, Jyrki Heino   +3 more
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Epitope-Based Chicken-Derived Novel Anti-PAD2 Monoclonal Antibodies Inhibit Citrullination

Journal of Immunology Research, 2021
The aberrant upregulation of protein arginine deiminase 2- (PAD2-) catalyzed citrullination is reported in various autoimmune diseases (rheumatoid arthritis and multiple sclerosis) and several cancers.
Masayoshi Aosasa, Md Saddam Hossain, Tomoko Sakata, Keita Koga, Takanari Shigemitsu, Yuji Shoya, Motonori Yamaguchi, Kenji Saito, Mujo Kim   +8 more
doaj   +1 more source

Citrullination only infrequently impacts peptide binding to HLA class II MHC. [PDF]

PLoS ONE, 2017
It has been hypothesized that HLA class II alleles associated with rheumatoid arthritis (RA) preferentially present self-antigens altered by post-translational modification, such as citrullination.
John Sidney, Stephane Becart, Mimi Zhou, Karen Duffy, Mikaela Lindvall, Erin C Moore, Eugene L Moore, Tadimeti Rao, Navin Rao, Morten Nielsen, Bjoern Peters, Alessandro Sette   +11 more
doaj   +1 more source

Interaction between extracellular matrix molecules and microbial pathogens: evidence for the missing link in autoimmunity with rheumatoid arthritis as a disease model. [PDF]

, 2014
Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammation followed by tissue rebuilding or fibrosis. A failure by the body to regulate inflammation effectively is one of the hallmarks of RA.
Bella, Blombäck, Chang, De Almeida, De Rycke, Everse, Fan, Gregersen, Hynes, Ioan-Facsinay, Klareskog, Li, Mahdi, McInnes, Meyer, Mikuls, Mundlos, Panayi, Perry, Ruiz-Esquide, Scher, Scott, Sofat, Symmons, Van Beers, van der Woude, van Heemst, Vincent, Wegner, Wellcome Trust Case Control Consortium, Weyand, Williams   +31 more
core   +6 more sources