Results 91 to 100 of about 14,198 (253)

Meeting update: faecal microbiota transplantation––bench, bedside, courtroom? [PDF]

, 2016
A group of stakeholders met, under the aegis of the British Society of Gastroenterology, to discuss the current landscape of faecal microbiota transplant- ation (FMT) within the UK and beyond.
Ding, N, Hart, A, Marchesi, J, McLaughlin, J, Mullish, BH   +4 more
core   +1 more source

PADI2‐Catalyzed MEK1 Citrullination Activates ERK1/2 and Promotes IGF2BP1‐Mediated SOX2 mRNA Stability in Endometrial Cancer

Advancement of science, 2021
Peptidylarginine deiminase II (PADI2) converts positively charged arginine residues to neutrally charged citrulline, and this activity has been associated with the onset and progression of multiple cancers. However, a role for PADI2 in endometrial cancer
Teng-fei Xue, Xiaoqiu Liu, Mei Zhang, Q. E, Shuting Liu, Maosheng Zou, Ying Li, Zhinan Ma, Yun Han, P. Thompson, Xuesen Zhang   +10 more
semanticscholar   +1 more source

Profiling Protein Citrullination in Extracellular Vesicles by Single‐Molecule Detection Using Direct Stochastic Optical Reconstruction Microscopy

Journal of Biophotonics, EarlyView.
This study identifies post‐translationally citrullinated/deiminated protein cargoes co‐localised to EV subtypes, using super resolution microscopy and dSTORM imaging. The findings expand current understanding of post‐translational modifications in EV‐mediated cellular communication.
Sarah R. Needham, Benjamin M. Davis, Pinar Uysal‐Onganer, Daniel J. Rolfe, Mariya Hristova, Igor Kraev, Jameel M. Inal, Sigrun Lange   +7 more
wiley   +1 more source

Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix

Nature Communications, 2018
Colorectal cancers (CRCs) often develop into untreatable metastatic disease of the liver. Here the authors report the modification of extracellular matrix proteins by citrullination in CRC metastases to the liver and propose that inhibition of ...
A. E. Yuzhalin, A. N. Gordon-Weeks, M. L. Tognoli, K. Jones, B. Markelc, R. Konietzny, R. Fischer, A. Muth, E. O’Neill, P. R. Thompson, P. J. Venables, B. M. Kessler, S. Y. Lim, R. J. Muschel   +13 more
doaj   +1 more source

Peptidylarginine deiminases as drug targets in neonatal hypoxic-ischemic encephalopathy [PDF]

, 2016
Oxygen deprivation and infection are major causes of perinatal brain injury leading to cerebral palsy and other neurological disabilities. The identification of novel key factors mediating white and grey matter damage are crucial to allow better ...
Adhami, Alonso-Alconada, Azad, Baburamani, Balandraud, Balduini, Block, Bozdag, Brinkmann, Brown, Byrd, Chavanas, Chavanas, Cherian, Cherrington, Choi, Christophorou, Cotten, Cui, Culman, David, Dingley, Dixon, Douglas-Escobar, Dragunow, Dwivedi, Erny, Fan, Faulkner, Ferretti, Ferriero, Fox, Fricker, Garcia-Romo, Ginet, Goyal, Guerrin, Gupta, Gupta, György, Hagberg, Hagberg, Hagiwara, Horibata, Imm, Ireland, Ireland, Karlsson, Kearney, Keilhoff, Kendall, Kendall, Kessenbrock, Keunen, Kholia, Knuckley, Kopatz, Kumral, Kurinczuk, Lande, Lange, Lange, Latuga, Law, Lee, Li, Li, Li, Loos, Loos, Luo, Ma, Mallard, Mallard, Marcos, Mari, Martin, Mastronardi, McCormack, Mirza, Moelants, Moelants, Musse, Neeli, Neeli, Neher, Neher, Neniskyte, Neumann, Northington, Perlman, Pirianov, Prempunpong, Proost, Robertson, Robertson, Rocha-Ferreira, Romano-Keeler, Romero, Sharda, Sherman, Simak, Slack, Spengler, Stenberg, Stys, Subramanian, Trabocchi, U, Uria-Avellanal, Villanueva, Vossenaar, Wang, Wang, Wassink, Wei, Witalison, Wood, Wright, Wu, Wu, Wyatt, Wyatt, Yektaei-Karin, Yi, Yost, Zhu, Zhu, Zhu, Zhu, Zipfel   +130 more
core   +2 more sources

Biosynthesis of Citrulline in Plants [PDF]

Nature, 1961
IN 1930 citrulline was discovered in water-melons1. Later it was shown to be an important participant in the Krebs and Henseleit ornithine cycle in animals and micro-organisms. In recent years several laboratories have worked on the ornithine cycle in plants.
openaire   +2 more sources

Compartmentalized citrullination in Muller glial endfeet during retinal degeneration

Proceedings of the National Academy of Sciences of the United States of America, 2022
Muller glia (MG) play a central role in reactive gliosis, a stress response associated with rare and common retinal degenerative diseases, including age-related macular degeneration (AMD). The posttranslational modification citrullination targeting glial
S. Palko, Nicholas J Saba, Elias M. Mullane, Benjamin D Nicholas, Yosuke Nagasaka, J. Ambati, Bradley D. Gelfand, A. Ishigami, P. Bargagna-mohan, R. Mohan   +9 more
semanticscholar   +1 more source

Respiratory Syncytial Virus (RSV): A Comprehensive Overview From Basic Biology to Clinical Prevention and Control

Medicinal Research Reviews, EarlyView.
ABSTRACT Respiratory syncytial virus (RSV) is a common virus that causes respiratory infections, posing a serious threat, particularly to infants, the elderly, and individuals with compromised immune systems. As the leading cause of lower respiratory tract infections (LRTIs) in infants, RSV is responsible for millions of cases worldwide each year.
Jie Shi, Xiya Huang, Chunjun Ye, Yishan Lu, Yanyan Liu, Yuquan Wei, Xiawei Wei   +6 more
wiley   +1 more source

Peptidylarginine Deiminase 2 Autoantibodies Are Linked to Less Severe Disease in Multiple Sclerosis and Post-treatment Lyme Disease

Frontiers in Neurology, 2022
BackgroundPeptidylarginine deiminase 2 (PAD2) mediates the post-translational conversion of arginine residues in proteins to citrullines and is highly expressed in the central nervous system (CNS).
Yaewon Kim, Alison W. Rebman, Alison W. Rebman, Tory P. Johnson, Hong Wang, Ting Yang, Ting Yang, Carlo Colantuoni, Carlo Colantuoni, Carlo Colantuoni, Pavan Bhargava, Michael Levy, Peter A. Calabresi, John N. Aucott, John N. Aucott, Mark J. Soloski, Mark J. Soloski, Erika Darrah, Erika Darrah   +18 more
doaj   +1 more source

Association between antibodies to carbamylated proteins and subclinical atherosclerosis in rheumatoid arthritis patients [PDF]

, 2017
BACKGROUND: Rheumatoid arthritis (RA) patients carry a high risk of cardiovascular morbidity and mortality. The excess of cardiovascular disease cannot be entirely explained by traditional risk factors and the immune system contributes to the development
Alessandri, Cristiano, Ciciarello, Francesco Luigi, Colasanti, Tania, Conti, Fabrizio, DI FRANCO, Manuela, Miranda, Francesca, Pecani, Arbi, Spinelli, FRANCESCA ROMANA, Valesini, Guido   +8 more
core   +1 more source