Results 101 to 110 of about 14,198 (253)

Implications of Post-Translational Modifications in Autoimmunity with Emphasis on Citrullination, Homocitrullination and Acetylation for the Pathogenesis, Diagnosis and Prognosis of Rheumatoid Arthritis

International Journal of Molecular Sciences, 2022
Post-translational modifications (PTMs) influence cellular processes and consequently, their dysregulation is related to the etiologies of numerous diseases.
I. Haro, R. Sanmartí, M. Gómara
semanticscholar   +1 more source

Application Strategies of Bone Marrow Mesenchymal Stromal Cells in Bone‐Related Diseases

Cell Proliferation, EarlyView.
Engineered BMSCs and vesicles enhance therapy effects for bone diseases via multi‐strategic approaches. ABSTRACT Bone‐related diseases (e.g., osteoporosis, osteoarthritis and fractures) exhibit a rising global incidence, imposing significant burdens on both quality of life and healthcare systems.
Xuemei Long, Dan Tan, Qianke Tao, Qiaonan Ye, Luwen Ye, Qing Li, Jingang Xiao   +6 more
wiley   +1 more source

Coordinated actions of microRNAs with other epigenetic factors regulate skeletal muscle development and adaptation [PDF]

, 2017
Epigenetics plays a pivotal role in regulating gene expression in development, in response to cellular stress or in disease states, in virtually all cell types.
Adamo, Sergio, Bianchi, Marzia, Moresi, Viviana, Renzini, Alessandra   +3 more
core   +1 more source

Determination of Citrulline in Plasma

Clinical Chemistry, 1960
Abstract The Archibald method for the determination of plasma citrulline has been modified to eliminate the dialysis step in order to separate citrulline from plasma proteins. Instead these are precipitated with picric acid and the picrate ion removed by passage through an anion exchange column.
M P, MOCKLER, L R, MENEBROKER, F L, HUMOLLER, A J, BARAK   +3 more
openaire   +2 more sources

Citrullinated fibrinogen detected as a soluble citrullinated autoantigen in rheumatoid arthritis synovial fluids [PDF]

Annals of the Rheumatic Diseases, 2006
Anti-citrullinated protein antibodies (ACPA) are specifically and frequently detected in sera of patients with rheumatoid arthritis (RA). Citrullinated fibrin or fibrinogen is a candidate autoantigen of such antibodies.To investigate the presence of citrullinated fibrinogen (cFBG) in the plasma or synovial fluid of patients with RA and control patients,
Y, Takizawa, A, Suzuki, T, Sawada, M, Ohsaka, T, Inoue, R, Yamada, K, Yamamoto   +6 more
openaire   +2 more sources

The Keystone‐Pathogen Hypothesis Updated: The Role of Porphyromonas gingivalis in Periodontitis

Journal of Periodontal Research, EarlyView.
Porphyromonas gingivalis orchestrates a coordinated manipulation of immune and inflammatory responses in periodontal tissues which leads to the generation of a dysbiotic, subgingival biofilm community, and progression of periodontitis. The type 9 secretion system, lipid A modification, and the formation of outer membrane vesicles are important ...
Mike A. Curtis, James A. Garnett, Richard P. Darveau   +2 more
wiley   +1 more source

Genomic signatures of adaptive introgression from European mouflon into domestic sheep [PDF]

, 2017
Mouflon (Ovis aries musimon) became extinct from mainland Europe after the Neolithic, but remnant populations from the Mediterranean islands of Corsica and Sardinia have been used for reintroductions across Europe since the 19th-century.
Barbato, Mario, Bruford, Michael W., Cabras, Pierangela, Hailer, Frank, Kijas, James, Mazza, Raffaele, Mereu, Paolo, Orozco-ter Wengel, Pablo, Pirastru, Monica   +8 more
core   +2 more sources

Citrulline Evaluation in Bowel Transplantation

Transplantation Proceedings, 2010
The purpose of this study was to evaluate the correlation of plasma citrulline and rejection episodes in intestinal transplantation.From January 2007 until present, we performed citrulline assays on our small bowel patients. We investigated the correlation of these assays with the rejection status of the patients.
Department of Surgery, University of Miami School of Medicine, Miami, Florida, USA ( host institution ), Ruiz, P. ( author ), Tryphonopoulos, P. ( author ), Island, E. ( author ), Selvaggi, G. ( author ), Nishida, S. ( author ), Moon, J. ( author ), Berlanga, A. ( author ), Defranc, T. ( author ), Levi, D. ( author ), Tekin, A. ( author ), Tzakis, A.G. ( author )   +11 more
openaire   +3 more sources

Autoimmunity and Periodontitis

Journal of Periodontal Research, EarlyView.
In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga, Vivek Thumbigere‐Math, Mark C. Herzberg   +2 more
wiley   +1 more source

Candida albicans-Induced NETosis Is Independent of Peptidylarginine Deiminase 4

Frontiers in Immunology, 2018
Neutrophils are the most abundant innate immune cells and the first line of defense against many pathogenic microbes, including the human fungal pathogen Candida albicans.
Eva Guiducci, Christina Lemberg, Noëmi Küng, Elisabeth Schraner, Alexandre P. A. Theocharides, Salomé LeibundGut-Landmann   +5 more
doaj   +1 more source