Results 111 to 120 of about 14,198 (253)

A guide to chemokines and their receptors [PDF]

, 2018
The chemokines (or chemotactic cytokines) are a large family of small, secreted proteins that signal through cell surface G‐protein coupled heptahelical chemokine receptors.
Braun A, Dyer DP, Garton KJ, Gupta SK, Hundelshausen P, Janssens R, Murphy PM, Sozzani S, Speck RF, Suan D, Woollard SM, Zheng Y   +11 more
core   +1 more source

Localized Periodontitis in Young Individuals: Aggregatibacter JP2 Clone, Immunological Dysfunctions and Other Stories

Journal of Periodontal Research, EarlyView.
This review describes the features of grade C molar‐incisor pattern periodontitis and discusses the role of A. actinomycetemcomitans in its pathogenesis and why molars and incisors are preferably affected. Possible future studies on this aggressive disease in primary and permanent dentition and emerging omics techniques for diagnosis and management are
Luigi Nibali, Meaad M. Alamri, Manuela Maria Viana Miguel, Luciana Shaddox   +3 more
wiley   +1 more source

Potential Role of Peptidylarginine Deiminase Enzymes and Protein Citrullination in Cancer Pathogenesis

Biochemistry Research International, 2012
The peptidylarginine deiminases (PADs) are a family of posttranslational modification enzymes that catalyze the conversion of positively charged protein-bound arginine and methylarginine residues to the uncharged, nonstandard amino acid citrulline.
Sunish Mohanan, Brian D. Cherrington, Sachi Horibata, John L. McElwee, Paul R. Thompson, Scott A. Coonrod   +5 more
doaj   +1 more source

GnRH Induces Citrullination of the Cytoskeleton in Murine Gonadotrope Cells

International Journal of Molecular Sciences
Peptidylarginine deiminases (PADs or PADIs) catalyze the conversion of positively charged arginine to neutral citrulline, which alters target protein structure and function. Our previous work established that gonadotropin-releasing hormone agonist (GnRHa)
Elizabeth B. Quigley, Stanley B. DeVore, Shaihla A. Khan, Zachary M. Geisterfer, H. Rothfuss, Ari O Sequoia, Paul R. Thompson, Jesse C Gatlin, Brian D. Cherrington, Amy M. Navratil   +9 more
semanticscholar   +1 more source

Characterization of the Hypercitrullination Reaction in Human Neutrophils and Other Leukocytes

Mediators of Inflammation, 2015
Autoantibodies against citrullinated proteins are diagnostic for rheumatoid arthritis. However, the molecular mechanisms driving protein citrullination in patients with rheumatoid arthritis remain poorly understood. Using two independent western blotting
Yebin Zhou, Tiziana Di Pucchio, Gary P. Sims, Nanette Mittereder, Tomas Mustelin   +4 more
doaj   +1 more source

Autoantibodies in inflammatory arthritis [PDF]

, 2016
Rheumatoid arthritis (RA) is a systemic chronic inflammatory disease characterized by extensive synovitis resulting in erosions of articular cartilage and marginal bone with joint destruction.
Chimenti, Ms, Conigliaro, P, Novelli, L, Perricone, C, Perricone, R, Sunzini, F, Triggianese, P   +6 more
core   +1 more source

La désimination ou citrullination [PDF]

médecine/sciences, 2011
La desimination, aussi nommee citrullination, est une modification post-traductionnelle aux multiples facettes. Elle est impliquee dans de nombreux processus cellulaires physiologiques comme la regulation genique, le developpement embryonnaire ou encore la differenciation terminale, mais aussi dans divers mecanismes physiopathologiques lies a des ...
Marie-Claire Méchin, Rachida Nachat, Fanny Coudane, Véronique Adoue, Jacques Arnaud, Guy Serre, Michel Simon   +6 more
openaire   +1 more source

Protein Arginine Deiminases (PADs): Biochemistry and Chemical Biology of Protein Citrullination.

Accounts of Chemical Research, 2019
Proteins are well-known to undergo a variety of post-translational modifications (PTMs). One such PTM is citrullination, an arginine modification that is catalyzed by a group of hydrolases called protein arginine deiminases (PADs).
S. Mondal, P. Thompson
semanticscholar   +1 more source

Periodontitis and rheumatoid arthritis—Global efforts to untangle two complex diseases

Periodontology 2000, EarlyView.
Abstract Understanding the impact of oral health on rheumatoid arthritis (RA) will inform how best to manage patients with both periodontitis and RA. This review seeks to provide an update on interventional and mechanistic investigations, including a brief summary of European Research programs investigating the link between periodontitis and RA. Recent
Isabel Lopez‐Oliva, Jennifer Malcolm, Shauna Culshaw   +2 more
wiley   +1 more source

Citrullination regulates pluripotency and histone H1 binding to chromatin. [PDF]

, 2014
Citrullination is the post-translational conversion of an arginine residue within a protein to the non-coded amino acid citrulline. This modification leads to the loss of a positive charge and reduction in hydrogen-bonding ability. It is carried out by a
A Gaspar-Maia, A Jedrusik, A Shevchenko, AK Hadjantonakis, Aliaksandra Radzisheuskaya, C Tanikawa, Clara Slade Oliveira, DT Brown, E Darrah, E Meshorer, ER Vossenaar, FA Goytisolo, GK Smyth, GL Cuthbert, Gonçalo Castelo-Branco, H Asaga, H Marks, H Niwa, I Neeli, J Cox, J Cox, J Cox, J Silva, J Silva, JE Elias, JE Jones, JM Polo, John B. Gurdon, José C. R. Silva, JV Olsen, JV Olsen, K Martinod, Kerri A. Mowen, M Bischoff, M Brahmajosyula, M Buttinelli, M Zernicka-Goetz, Magdalena Zernicka-Goetz, Maria A. Christophorou, Michael L. Nielsen, ML Nielsen, NL Barbosa-Morais, P Du, P Li, Paul Bertone, QL Ying, R Kan, R Schnabel, Remco Loos, Richard P. Halley-Stott, RP Halley-Stott, S Ding, S Falcon, S Masui, S Rozen, S Wang, S Yamanaka, T Bartke, T Hagiwara, Tony Kouzarides, TW Theunissen, TW Theunissen, X Chang, X Zhang, X Zhang, Y Fan, Y Luo, Y Wang, Y Zhang   +68 more
core   +1 more source