Results 121 to 130 of about 14,198 (253)
Tolerogenic citrullinated peptide for arthritis
Oncotarget, 2015 Disease-specific autoantibodies directed against post-translation citrullinated proteins/peptides (ACPAs) are specific serological markers for rheumatoid arthritis (RA) and have been accepted as one of the classification criteria for the disease. Beyond diagnosis these autoantibodies have also been shown also to predict disease severity.
Smadar, Gertel +2 more
openaire +2 more sources
Journal of Clinical Periodontology, Volume 53, Issue 3, Page 466-477, March 2026.ABSTRACT Aim To explore mechanistic links between rheumatoid arthritis (RA) and periodontitis (PD) through the lens of subgingival microbial dysbiosis–mediated inflammation. Methods Subgingival plaque from 100 volunteers with RA and PD (RAPD), 22 with RA (RAnoPD), 18 with PD (PDnoRA) and 19 healthy controls (noRAnoPD) was analysed using 16S‐amplicon ...
Isabel Lopez‐Oliva +11 more
wiley +1 more source
Reduced TCR-dependent activation through citrullination of a T-cell epitope enhances Th17 development by disruption of the STAT3/5 balance [PDF]
, 2016 Citrullination is a post-translational modification of arginine that commonly occurs in inflammatory tissues. Because T-cell receptor (TCR) signal quantity and quality can regulate T-cell differentiation, citrullination within a T-cell epitope has ...
Falconer, Jane +5 more
core +1 more source
Cell Reports, 2018 Summary: Recent proteome analyses have provided a comprehensive overview of various posttranslational modifications (PTMs); however, PTMs involving protein citrullination remain unclear. We performed a proteomic analysis of citrullinated proteins, and we
Chizu Tanikawa +14 more
doaj +1 more source
Clinical and Experimental Dental Research, Volume 12, Issue 1, February 2026.ABSTRACT Objectives Chronic kidney disease (CKD) is relatively common in patients with rheumatoid arthritis (RA). Periodontitis and periodontopathic Porphyromonas gingivalis are risk factors for CKD. However, the association of serum immunity to P. gingivalis and its peptidylarginine deiminase (PPAD), as well as periodontitis severity, with CKD in ...
Tetsuo Kobayashi +5 more
wiley +1 more source
Frontiers in Immunology, 2018 Protein citrullination catalyzed by peptidyl arginine deiminase (PADs) is involved in autoimmune disease pathogenesis, especially in rheumatoid arthritis.
Yebin Zhou +2 more
doaj +1 more source
Hand to Mouth: A Systematic Review and Meta-Analysis of the Association between Rheumatoid Arthritis and Periodontitis [PDF]
, 2016 Background: Rheumatoid arthritis (RA) and periodontitis are both chronic inflammatory diseases, which demonstrate similarities in terms of mechanism, histopathology, and demography. An association between these conditions has been demonstrated previously
Abou-Raya +57 more
core +2 more sources
ACR Open Rheumatology, Volume 8, Issue 1, January 2026.Objective Emerging evidence suggests that apolipoprotein E (apoE) may be involved in the immune system and diseases driven by chronic inflammation. The impact of the full range of structural genetic variation in APOE for risk of rheumatoid arthritis, psoriasis, and psoriatic arthritis in the general population is not known.
Katrine L. Rasmussen +5 more
wiley +1 more source
Reduced glutathione as a physiological co-activator in the activation of peptidylarginine deiminase [PDF]
, 2016 BACKGROUND: Citrullination catalysed by peptidylarginine deiminases (PADs) plays an important pathogenic role in anti-citrullinated protein antibody (ACPA)-positive rheumatoid arthritis (RA) and, possibly, several other inflammatory diseases.
Claus H. Nielsen +4 more
core +1 more source
A specific amino acid motif of HLA-DRB1 mediates risk and interacts with smoking history in Parkinson's disease. [PDF]
, 2019 Parkinson's disease (PD) is a neurodegenerative disease in which genetic risk has been mapped to HLA, but precise allelic associations have been difficult to infer due to limitations in genotyping methodology.
Anderson, Kirsten M +18 more
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