Results 11 to 20 of about 14,198 (253)

Citrullination modulation stabilizes HIF-1α to promote tumour progression

Nature Communications
Citrullination plays an essential role in various physiological or pathological processes, however, whether citrullination is involved in regulating tumour progression and the potential therapeutic significance have not been well explored.
Rui Chen, Zhiyuan Lin, Shengqi Shen, Chuxu Zhu, Kai Yan, Caixia Suo, Rui Liu, Haoran Wei, Li Gao, Kaixiang Fan, Huafeng Zhang, Linchong Sun, Ping Gao   +12 more
doaj   +2 more sources

Citrullination in health and disease: From physiological function to gene regulation

Genes and Diseases
Protein citrullination involves the deimination of arginine or methylarginine residues in peptide chains to form citrulline by peptidyl arginine deiminases.
Xiaoya Zhang, Guiqiu Xie, Lang Rao, Chaoguang Tian   +3 more
doaj   +2 more sources

The Role of Citrullination Modification in CD4⁺ T Cells in the Pathogenesis of Immune-Related Diseases

Biomolecules
The post-translational modifications (PTMs) of proteins play a crucial role in increasing the functional diversity of proteins and are associated with the pathogenesis of various diseases. This review focuses on a less explored PTM called citrullination,
Yuhang Chen, Yi Teng, Ping Xu, Shengjun Wang   +3 more
doaj   +2 more sources

Peptidylarginine deiminase 2 plays a key role in osteogenesis by enhancing RUNX2 stability through citrullination

Cell Death and Disease, 2023
Peptidylarginine deiminase (PADI) 2 catalyzes the post-translational conversion of peptidyl-arginine to peptidyl-citrulline in a process called citrullination. However, the precise functions of PADI2 in bone formation and homeostasis remain unknown.
Hyun-Jung Kim, Hye-Rim Shin, Heein Yoon, Min-Sang Park, Byung-Gyu Kim, Jae-I Moon, Woo-Jin Kim, Seung Gwa Park, Ki-Tae Kim, Ha-Neui Kim, Je-Yong Choi, Hyun-Mo Ryoo   +11 more
doaj   +2 more sources

Citrullination of C1-inhibitor as a mechanism of impaired complement regulation in rheumatoid arthritis

Frontiers in Immunology, 2023
BackgroundDysregulated complement activation, increased protein citrullination, and production of autoantibodies against citrullinated proteins are hallmarks of rheumatoid arthritis (RA).
Myriam Martin, Sara C. Nilsson, David Eikrem, Karin Fromell, Carsten Scavenius, Leonie M. Vogt, Ewa Bielecka, Jan Potempa, Jan Potempa, Jan J. Enghild, Bo Nilsson, Kristina N. Ekdahl, Kristina N. Ekdahl, Meliha C. Kapetanovic, Anna M. Blom   +14 more
doaj   +2 more sources

Evidence of membranolytic targeting and intracellular citrullination in neutrophils isolated from patients with rheumatoid arthritis

Scientific Reports
Anti-citrullinated protein autoantibodies (ACPA) are diagnostic for rheumatoid arthritis (RA). The antigens recognized by these autoantibodies are produced by protein arginine deiminases (PADs), particularly PAD4.
Fatemeh Moadab, Xiaoxing Wang, Ethan Le, Tal Gazitt, Rayan Najjar, J. Lee Nelson, Vijay Joshua, Vivianne Malmström, Keith Elkon, Caroline Grönwall, Tomas Mustelin   +10 more
doaj   +2 more sources

PAD-mediated citrullination is a novel candidate diagnostic marker and druggable target for HPV-associated cervical cancer

Frontiers in Cellular and Infection Microbiology
Citrullination is an emerging post-translational modification catalyzed by peptidyl-arginine deiminases (PADs) that convert peptidyl-arginine into peptidyl-citrulline. In humans, the PAD family consists of five isozymes (PADs 1-4, 6) involved in multiple
Camilla Albano, Matteo Biolatti, Jasenka Mazibrada, Selina Pasquero, Francesca Gugliesi, Irene Lo Cigno, Federica Calati, Greta Bajetto, Greta Bajetto, Greta Bajetto, Giuseppe Riva, Gloria Griffante, Gloria Griffante, Santo Landolfo, Marisa Gariglio, Marco De Andrea, Marco De Andrea, Valentina Dell’Oste   +17 more
doaj   +2 more sources

Citrullination in the pathology of inflammatory and autoimmune disorders: recent advances and future perspectives

Cellular and Molecular Life Sciences, 2022
Numerous post-translational modifications (PTMs) govern the collective metabolism of a cell through altering the structure and functions of proteins.
Oskar Ciesielski, Marta Biesiekierska, Baptiste Panthu, M. Soszyński, L. Pirola, A. Balcerczyk   +5 more
semanticscholar   +1 more source

Citrullination modulates antigen processing and presentation by revealing cryptic epitopes in rheumatoid arthritis

Nature Communications, 2023
Cryptic peptides, hidden from the immune system under physiologic conditions, are revealed by changes to MHC class II processing and hypothesized to drive the loss of immune tolerance to self-antigens in autoimmunity.
A. Curran, Alexander A. Girgis, Yura Jang, Jonathan D. Crawford, M. A. Thomas, Ryan Kawalerski, Jeff Coller, C. O. Bingham, Chan-Hyun Na, E. Darrah   +9 more
semanticscholar   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source