Human cytomegalovirus-induced host protein citrullination is crucial for viral replication
Nature Communications, 2021 Citrullination is a posttranslational modification of arginines. Here, the authors show that HCMV infection increases citrullination of host and virus proteins to promote infection and that citrullinated interferon-inducible protein IFIT1 is impaired in ...
Gloria Griffante +17 more
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A Hairy Cituation – PADIs in Regeneration and Alopecia
Frontiers in Cell and Developmental Biology, 2021 In this Review article, we focus on delineating the expression and function of Peptidyl Arginine Delminases (PADIs) in the hair follicle stem cell lineage and in inflammatory alopecia. We outline our current understanding of cellular processes influenced
Kim Vikhe Patil +2 more
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Earthworm coelomocyte extracellular traps : structural and functional similarities with neutrophil NETs [PDF]
, 2018 ROD UJ /
Joanna Homa
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Citrullination – small change with a great consequence [PDF]
, 2013 Citrullination is one of the possible post-translational modifications of proteins. It is based on a conversion of L-arginine residue (L-Arg) to L-citrulline residue (L-Cit). The reaction is catalyzed by peptidylarginine deiminases (PAD). The change of L-
Gogól Mariusz
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Citrullination and Autophagy [PDF]
, 2017 During evolution, the eukaryotic cells develop different processes in order to adapt themselves to environmental changes, as well as to die or to survive. These processes include apoptosis, NETosis, and autophagy: citrullination is implicated in all of these physiological mechanisms.
Guido Valesini +5 more
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Autophagy, citrullination and cancer [PDF]
Autophagy, 2016 A cell needs to maintain a balance between biosynthesis and degradation of cellular components to maintain homeostasis. There are 2 pathways, the proteasome, which degrades short-lived proteins, and the autophagy/lysosomal pathway, which degrades long-lived proteins and organelles. Both of these pathways are also involved in antigen presentation or the
Lindy G, Durrant +2 more
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Protein citrullination: A proposed mechanism for pathology in traumatic brain injury
Frontiers in Neurology, 2015 Protein citrullination is a calcium-driven post-translational modification proposed to play a causative role in the neurodegenerative disorders of Alzheimer’s disease, multiple sclerosis (MS) and prion disease.
Rachel C Lazarus +10 more
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Methylation-dependent PAD2 upregulation in multiple sclerosis peripheral blood [PDF]
, 2012 Background: Peptidylarginine deiminase 2 (PAD2) and peptidylarginine deiminase 4 (PAD4) are two members of PAD family which are over-expressed in the multiple sclerosis (MS) brain.
ANNIBALI, Viviana +9 more
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Expression of citrulline and homocitrulline residues in the lungs of non-smokers and smokers : implications for autoimmunity in rheumatoid arthritis [PDF]
, 2015 Introduction: Smoking is a well-established risk factor for rheumatoid arthritis (RA), and it has been proposed that smoking-induced citrullination renders autoantigens immunogenic.
Bracke, Ken +8 more
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Regulation of glycolysis and cancer cell proliferation by PKM2 citrullination
Molecular & Cellular Oncology, 2021 Conversion of peptidyl-arginine to peptidyl citrulline, known as citrullination, is a post-translational protein modification catalyzed by the PADI (Protein Arginine Deiminase) family of enzymes. PADI1 and PADI3 catalyze citrullination of arginine 106 in
Sébastien Coassolo, Irwin Davidson
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