Results 61 to 70 of about 14,198 (253)

Joint inflammation related citrullination of functional arginines in extracellular proteins

Scientific Reports, 2017
We report the extent, specific sites and structural requirements of joint inflammation related citrullination in extracellular proteins. A total of 40 synovial fluid samples derived from chronically inflamed human joints were analysed by heparin-agarose ...
Kalle H. Sipilä, Vipin Ranga, Pekka Rappu, Markku Mali, Laura Pirilä, Ilona Heino, Johanna Jokinen, Jarmo Käpylä, Mark S. Johnson, Jyrki Heino   +9 more
doaj   +1 more source

Rheumatoid arthritis [PDF]

, 2016
Rheumatoid arthritis is a chronic inflammatory joint disease, which can cause cartilage and bone damage as well as disability. Early diagnosis is key to optimal therapeutic success, particularly in patients with well-characterised risk factors for poor ...
Aletaha, Daniel, McInnes, Iain B., Smolen, Josef S.   +2 more
core   +1 more source

Citrullination and carbamylation in the pathophysiology of rheumatoid arthritits

Frontiers in Immunology, 2015
The discovery that citrullination was crucial for the recognition of antigens by the most disease-specific class of autoantibodies in rheumatoid arthritis had a huge impact on studies aimed at understanding autoimmunity in this disease.
Ger J.M. Pruijn
doaj   +1 more source

Role of PAD enzymes on histone citrullination in cancer

Medical Journal of Babylon, 2022
Citrullination process is a natural pathway which happened at the time of cell dying, but during removal of these products, PAD enzymes may release causing stimuli to the immune system.
Noor Mohammed Abdulrahman, Shatha Hussein Ali   +1 more
doaj   +1 more source

Genetic variations in A20 DUB domain provide a genetic link to citrullination and neutrophil extracellular traps in systemic lupus erythematosus [PDF]

, 2019
Objectives: Genetic variations in TNFAIP3 (A20) de-ubiquitinase (DUB) domain increase the risk of systemic lupus erythematosus (SLE) and rheumatoid arthritis.
Alexsson, Andrei,, Arthur, Simon,, Bengtsson, Anders,, Cohen, Philip,, Collins, Barry,, Eloranta, Maija Leena,, Gunnarsson, Iva,, Jackson, Sonya,, Jevnikar, Zala,, Johansson, Patrik,, Jönsen, Andreas,, Kastbom, Alf,, Knebel, Axel,, Leonard, Dag,, Lund University., Lund University., Mattsson, Johan,, Nanda, Sambit,, Odqvist, Lina,, Rantapää-Dahlqvist, Solbritt,, Rhedin, Magdalena,, Riise, Rebecca,, Rönnblom, Lars,, Sandling, Johanna K.,, Sjöwall, Christopher,, Svenungsson, Elisabet,, Syvänen, Ann Christine,, Tandre, Karolina,, Thörn, Kristofer,, Vaarala, Outi,, Yrlid, Linda,, Öberg, Lisa,   +31 more
core   +2 more sources

Small molecule activates citrullination through targeting PAD2

Philosophical Transactions of the Royal Society of London. Biological Sciences, 2023
Citrullination is a post-translational modification catalysed by peptidyl arginine deiminase (PAD) enzymes, and dysregulation of protein citrullination is involved in various pathological disorders.
Xue Zhang, Mengzhen Shen, Huimin Zhu, Junjie Zhang, Min Yang, Kaiyan Su, Yirong Zhang, Wei Fu, X. Ke, Yi Qu   +9 more
semanticscholar   +1 more source

A quantitative and site-specific atlas of the in vivo citrullinome reveals widespread existence of citrullination

bioRxiv, 2023
Citrullination is the conversion of peptidyl-arginine into the non-coded amino acid citrulline. Despite its importance in physiology and disease, global identification of citrullinated proteins and precise modification sites has remained challenging ...
A. S. Rebak, I. Hendriks, Sara C. Buch-Larsen, J. D. Elsborg, Rebecca Kirsch, N. Doncheva, Lars Jørn Jensen, M. Christophorou, M. L. Nielsen   +8 more
semanticscholar   +1 more source

Zinc‐Containing Bioactive Glass Programs Macrophage Polarization through Extracellular Traps Regulation for Enhanced Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Zinc‐containing bioactive glass (ZnBG) promotes diabetic wound healing by regulating macrophage extracellular traps (METs). Specifically, ZnBG reduces oxidative stress and inhibits the PAD4 and NLRP3/caspase‐1/GSDMD signaling pathways, thereby suppressing MET formation.
RuiYang Sun, XueBo Wei, ZhuoYang Song, JunJun Luo, JingYi Ye, YinNan Zhang, LiFei Zhu, Jie Gao, Hongyu Zhang, Hong Zhu, Xin Wang, Ke Xu   +11 more
wiley   +1 more source

Exacerbation of symptomatic arthritis by cigarette smoke in experimental arthritis.

PLoS ONE, 2020
IntroductionEpidemiologically, cigarette smoking is a well-known risk factor for the pathogenesis of rheumatoid arthritis (RA). However, there has been few plausible explanations why cigarette smoking aggravated RA.
Jaewoo Kang, Sang Hoon Jeong, Kijun Lee, Narae Park, Hyerin Jung, Kyuhong Lee, Ji Hyeon Ju   +6 more
doaj   +1 more source

PCSPred_SC: Prediction of Protein Citrullination Sites Using an Effective Sequence-Based Combined Method

IEEE Access, 2020
As one of post-translational modifications (PTMs), protein citrullination is crucial in a diverse array of cellular processes and implicated in a slew of human pathology.
Lina Zhang, Jingui Chen, Chengjin Zhang, Rui Gao, Runtao Yang   +4 more
doaj   +1 more source