Borrelia burgdorferi BBK32 Inhibits the Classical Pathway by Blocking Activation of the C1 Complement Complex. [PDF]
PLoS Pathogens, 2016 Pathogens that traffic in blood, lymphatics, or interstitial fluids must adopt strategies to evade innate immune defenses, notably the complement system.
Brandon L Garcia +4 more
doaj +12 more sources
The contribution of the alternative pathway in complement activation on cell surfaces depends on the strength of classical pathway initiation [PDF]
Clinical & Translational Immunology, 2023 Objectives The complement system is an important component of innate immunity. The alternative pathway (AP) amplification loop is considered an essential feed forward mechanism for complement activation.
Esther CW deBoer +14 more
doaj +3 more sources
The classical pathway triggers pathogenic complement activation in membranous nephropathy [PDF]
Nature Communications, 2023 It is generally thought that complement activation in human membranous nephropathy (MN) occurs predominantly via the lectin or alternative pathway. Here, the authors show that the classical pathway is the dominant form of complement activation in MN and ...
Larissa Seifert +23 more
doaj +3 more sources
Functional and Structural Characterization of a Potent C1q Inhibitor Targeting the Classical Pathway of the Complement System [PDF]
Frontiers in Immunology, 2020 The classical pathway of complement is important for protection against pathogens and in maintaining tissue homeostasis, but excessive or aberrant activation is directly linked to numerous pathologies.
Nick S. Laursen +7 more
doaj +3 more sources
SALO, a novel classical pathway complement inhibitor from saliva of the sand fly Lutzomyia longipalpis. [PDF]
Sci Rep, 2016 Blood-feeding insects inject potent salivary components including complement inhibitors into their host's skin to acquire a blood meal. Sand fly saliva was shown to inhibit the classical pathway of complement; however, the molecular identity of the ...
Abdeladhim, M. +18 more
core +3 more sources
Quantification of classical and non-classical crystallization pathways in calcite precipitation [PDF]
Earth and Planetary Science Letters, 2022 Crystal precipitation from aqueous solution occurs through multiple pathways. Besides the classical ion-by-ion addition, non-classical crystallization mechanisms, such as multi-ion polymer and nano-particle attachment, could be of great significance under certain circumstances.
Zhongtian Zhang, Jiuyuan Wang
openaire +3 more sources
Direct versus Delayed pathways in Strong-Field Non-Sequential Double Ionization [PDF]
, 2010 We report full-dimensionality quantum and classical calculations for double ionization of laser-driven helium at 390 nm. Good qualitative agreement is observed.
A Emmanouilidou +7 more
core +3 more sources
Frontiers in Immunology, 2014 The classical pathway of complement plays multiple physiological roles including modulating immunological effectors initiated by adaptive immune responses as well as an essential homeostatic role in the clearance of damaged self-antigens.
Julia A Sharp +5 more
doaj +2 more sources
Nucleation of colloids and macromolecules: does the nucleation pathway matter? [PDF]
, 2012 A recent description of diffusion-limited nucleation based on fluctuating hydrodynamics that extends classical nucleation theory predicts a very non-classical two-step scenario whereby nucleation is most likely to occur in spatially-extended, low ...
Bernstein J. +3 more
core +2 more sources
Novel Evasion Mechanisms of the Classical Complement Pathway [PDF]
The Journal of Immunology, 2016 Abstract Complement is a network of soluble and cell surface-associated proteins that gives rise to a self-amplifying, yet tightly regulated system with fundamental roles in immune surveillance and clearance. Complement becomes activated on the surface of nonself cells by one of three initiating mechanisms known as the classical, lectin,
B. Garcia +3 more
semanticscholar +3 more sources