Results 31 to 40 of about 4,411,154 (387)

An Evolutionary Pathway for the Quantum Internet Relying on Secure Classical Repeaters [PDF]

IEEE Network, 2022
Until quantum repeaters become mature, quantum networks remain restricted either to limited areas of directly connected nodes or to nodes connected to a common node.
G. Long, Dong Pan, Yu‐Bo Sheng, Qikun Xue, Jianhua Lu, L. Hanzo   +5 more
semanticscholar   +1 more source

The Sez6 Family Inhibits Complement by Facilitating Factor I Cleavage of C3b and Accelerating the Decay of C3 Convertases

Frontiers in Immunology, 2021
The Sez6 family consists of Sez6, Sez6L, and Sez6L2. Its members are expressed throughout the brain and have been shown to influence synapse numbers and dendritic morphology. They are also linked to various neurological and psychiatric disorders.
Wen Q. Qiu, Shaopeiwen Luo, Stefanie A. Ma, Priyanka Saminathan, Herman Li, Jenny M. Gunnersen, Harris A. Gelbard, Jennetta W. Hammond   +7 more
doaj   +1 more source

Proprotein Convertases and the Complement System

Frontiers in Immunology, 2022
Proteins destined for secretion - after removal of the signal sequence - often undergo further proteolytic processing by proprotein convertases (PCs).
József Dobó, Andrea Kocsis, Ráhel Dani, Péter Gál   +3 more
doaj   +1 more source

Inhibition of the Classical Pathway of Complement by Meningococcal Capsular Polysaccharides [PDF]

J Immunol, 2014
S. Agarwal, Shreekant Vasudhev, R. DeOliveira, S. Ram   +3 more
semanticscholar   +2 more sources

Effective Neutrophil Phagocytosis of Aspergillus fumigatus Is Mediated by Classical Pathway Complement Activation [PDF]

J Innate Immun, 2015
S. Braem, S. Rooijakkers, K. V. van Kessel, H. de Cock, H. Wösten, J. V. van Strijp, P. Haas   +6 more
semanticscholar   +2 more sources

Functional Analysis of Two Divergent C4 Isotypes in the Classical and Lectin Pathways of Complement Activation in the Common Carp (Cyprinus carpio)

Journal of Marine Science and Engineering, 2023
In the evolution of the complement system, a major humoral innate immune factor, the existence of multiple isotypes of the complement components is considered as a key strategy to enhance innate immune defense. Complement C4 is also diversified in a wide
Rosli Nehlah, Akira Yamamoto, Takahiro Nagasawa, Tomonori Somamoto, Miki Nakao   +4 more
doaj   +1 more source

Complement Activation-Independent Attenuation of SARS-CoV-2 Infection by C1q and C4b-Binding Protein

Viruses, 2023
The complement system is a key component of the innate immune response to viruses and proinflammatory events. Exaggerated complement activation has been attributed to the induction of a cytokine storm in severe SARS-CoV-2 infection.
Nazar Beirag, Praveen M. Varghese, Martin Mayora Neto, Ahmad Al Aiyan, Haseeb A. Khan, Moneeb Qablan, Mohamed H. Shamji, Robert B. Sim, Nigel Temperton, Uday Kishore   +9 more
doaj   +1 more source

An Ultrahigh-Affinity Complement C4b-Specific Nanobody Inhibits In Vivo Assembly of the Classical Pathway Proconvertase

Journal of Immunology, 2020
Key Points hC4Nb8 is a potent cross-reactive inhibitor of CP and LP proconvertase formation. hC4Nb8 binds to a neoepitope exposed upon C4 activation and C4b generation. hC4Nb8 inhibits the CP of complement in vivo.
A. Zarantonello, J. Presumey, Léa Simoni, Esra Yalcin, Rachel Fox, A. Hansen, H. Olesen, S. Thiel, Matthew B. Johnson, B. Stevens, N. S. Laursen, M. Carroll, G. Andersen   +12 more
semanticscholar   +1 more source

Safety and efficacy of classical complement pathway inhibition with sutimlimab in chronic immune thrombocytopenia

Blood Advances, 2022
Key Points • Classical complement pathway activation contributes to the pathophysiology and clinical heterogeneity of immune thrombocytopenia (ITP).• Sutimlimab rapidly and durably increased platelet count in patients with chronic ITP by selectively ...
C. Broome, A. Röth, D. Kuter, M. Scully, Roy E. Smith, Jennifer P. Wang, C. Reuter, W. Hobbs, A. Daak   +8 more
semanticscholar   +1 more source

cGAS/STING: novel perspectives of the classic pathway [PDF]

Molecular Biomedicine, 2020
AbstractCyclic GMP-AMP (cGAMP) synthase (cGAS) is a cytosolic DNA sensor and innate immune response initiator. Binding with exogenous or endogenous nucleic acids, cGAS activates its downstream adaptor, stimulator of interferon genes (STING). STING then triggers protective immune to enable the elimination of the pathogens and the clearance of cancerous ...
Menghui Gao, Yuchen He, Haosheng Tang, Xiangyu Chen, Shuang Liu, Yongguang Tao   +5 more
openaire   +4 more sources