Results 151 to 160 of about 20,415 (303)
Maxillary Sinus Papillary Edema as a Predictor of Odontogenic Sinusitis
The Laryngoscope, EarlyView.Maxillary sinus papillary edema (MSPE) is a distinct finding that is reliably identifiable, and is significantly more likely in odontogenic sinusitis (ODS) compared to infectious chronic rhinosinusitis without nasal polyps and noninfectious chronic rhinosinusitis with nasal polyps.Hussein Mackie, Japnam Jassal, Carl Wilson, Wamidh Alkhoory, Jacob G. Eide, Edward D. McCoul, John R. Craig +6 morewiley +1 more sourceDiagnostic Value of Glycocalyx Shedding in Blood for Differentiating between Parkinson's Disease and Multiple System Atrophy
Movement Disorders, EarlyView.Abstract Background
Blood–brain barrier disruption is increasingly recognized in synucleinopathies, but the role of the endothelial glycocalyx (GLX) in Parkinson's disease (PD) and multiple system atrophy (MSA) remains unclear. Objectives
The aim was to determine whether plasma GLX markers differ between PD, MSA, and healthy controls (HC), relate to ...Jonas Folke, Brian DellaValle, Mathias Lindh Jørgensen, Phillip Bredahl Mogensen, Casper Hempel, Jørgen Rungby, Anne‐Mette Hejl, Annemette Løkkegaard, Lisette Salvesen, Sara Bech, Mette Møller, Erik Hvid Danielsen, Morten Blaabjerg, Matthias Bode, Tomasz Brudek, Susana Aznar +15 morewiley +1 more sourceWhat practicing pathologists and oncologists should know about the new computational pathology‐based companion diagnostic tools
The Journal of Pathology, EarlyView.Abstract
The integration of artificial intelligence into pathology is transforming the assessment of histological and immunohistochemical (IHC) slides, offering opportunities to reduce variability and streamline diagnostics. In practical terms, most available tools and research models emulate the diagnostic capabilities of pathologists by detecting ...Diana Montezuma, Sara P. Oliveira, Inti Zlobec, Nadieh Khalili, Jordi Temprana‐Salvador, Sabine Leh, David Ameisen, Mircea‐Sebastian Șerbănescu, Arsela Prelaj, Jakob Nikolas Kather, Norman Zerbe, Vincenzo L'Imperio +11 morewiley +1 more sourceBeyond cell-cell adhesion: Emerging roles of the tight junction scaffold ZO-2 [PDF]
, 2013 Gehwolf, R., Krizbai, István Adorján, Toepfer, S., Traweger, A., Wagner, R.N., Wilhelm, Imola, Zweimueller-Mayer, J. +6 morecore +1 more sourceEpigenetic Dysregulation of the NKX2‐1/SPDEF Axis Drives Persistent Goblet Cell Differentiation and Epithelial Barrier Dysfunction in Chronic Obstructive Pulmonary Disease
Respirology, EarlyView.This study investigated airway epithelial barrier dysfunction persistence in ex‐smokers with COPD and underlying mechanisms using single‐cell RNA and ATAC sequencing. Epigenetic NKX2‐1/SPDEF dysregulation maintains goblet cell hyperplasia and barrier dysfunction despite long‐term smoking cessation.Ayaka Shiota, Keiko Kan‐o, Yumiko Ishii, Tomoaki Koga, Takeshi Sawada, Kei‐ichiro Yasunaga, Shingo Usuki, Tatsuya Katsuno, Shigesato Inoue, Tomohiro Ogawa, Akihiro Jo, Satoru Fukuyama, Mitsuyoshi Nakao, Hiroaki Ogata, Mizuho A. Kido, Sachiko Tsukita, Koichiro Matsumoto, Isamu Okamoto +17 morewiley +1 more sourceTight junctions and the modulation of barrier function in disease [PDF]
, 2008 Carola Förster, NJ Abbott, C Achler, M Ahdieh, Y Ando-Akatsuka, DA Antonetti, C Avolio, MS Balda, G Bazzoni, T Ben-Yosef, K- Brew, M Bruewer, N Burgel, C Chang, P Claude, B Cochand-Priollet, CJ Cohen, OR Colegio, G Conyers, PO Couraud, CB Coyne, EB Cramer, AH Cross, F D’Atri, E Dejana, K Ebnet, E Efrati, E Ehler, MG Farquhar, EA Felinski, E Ferrary, C Förster, JC Forrest, C Förster, C Förster, C Förster, M Furuse, M Furuse, M Furuse, M Furuse, M Furuse, M Furuse, SJ Giebel, MZ Gilcrease, L Gonzalez-Mariscal, NS Harhaj, KA Harkness, F Heller, T Hirase, D Hollander, KB Hoover, J Hou, J Hou, AJ Hudspeth, A Ikari, M Itoh, M Itoh, B Jovov, M Juhler, PJ Kausalya, AG Kermode, M Konrad, H Korner, F Kramer, K Kubota, DB Lee, D Leppert, Y Liu, H Long, TY Ma, I Martin-Padura, K Matter, K Matter, BA McClane, P Michl, LL Mitic, K Morita, S Morohashi, IJ Namer, A Nusrat, T Oshima, M Peeters, LS Poritz, S Prasad, LL Rubin, AD Sabag, M Saitou, M Saitou, EE Schneeberger, GM Sheehan, C Silwedel, DB Simon, MB Sobocka, AP Soler, N Sonoda, LA Staehelin, BR Stevenson, JG Swift, K Swisshelm, AM Tokes, S Tsukita, S Tsukita, JR Turner, VN Tzelepi, M Utech, JB Bree van, CM Itallie Van, CM Itallie Van, CM Itallie Van, S Vitale, Z Wang, Z Wang, M Wattenhofer, CR Weber, F Weber, ER Wilcox, H Wolburg, H Wolburg, V Wong, V Wong, DF Woods, BR Yacyshyn, Y Yang, VW Yong, A Youakim, A Zahraoui, S Zeissig, HP Zenner +127 morecore +1 more sourceMesoporous Silica Nanoparticles‐Based Formulations for Enhanced Oral Delivery of Peptide Drugs: A Case Study on Insulin
Small, EarlyView.This work explores the tailored functionalization of mesoporous silica nanoparticles (MSN) to improve the oral delivery of insulin, as a case study. Insulin confinement within silica mesopores increased drug solubility, and co‐formulation with succinylated β‐lactoglobulin yielded pH‐responsive tablets that limited gastric release and proteolysis, while Claudia Iriarte‐Mesa, Estelle Juère, Andrea Bileck, Thomas Kremsmayr, Michael L. Goodson, Allison Ehrlich, Adnan Hodžić, Martin Kunert, Christopher Gerner, Hanspeter Kählig, Doris Marko, Markus Muttenthaler, David Berry, Giorgia Del Favero, Freddy Kleitz +14 morewiley +1 more sourceBrain Pericytes and Wnt/β‐Catenin Signaling Induce Functional Blood–Brain Barrier Phenotype in Human iPSC‐Derived Model
Small Methods, EarlyView.This study shows that human iPSC‐derived endothelial cells acquire a functional blood–brain barrier phenotype when co‐cultured with brain pericytes and stimulated with CHIR‐99021, a Wnt/β‐catenin activator. This model recapitulates key barrier properties, inflammatory responses, and transcriptomic features of the native human BBB, offering new ...Henrique Nogueira Pinto, Nine R. Kok, Philipp C. Hauger, Manon Karsten‐van Diepen, Michael de Kok, Nanne J. Paauw, Susanne M. A. van der Pol, Joline P. Nugteren‐Boogaard, Peter L. Hordijk, Stephanie D. Beekhuis‐Hoekstra, Susan Gibbs, Nienke M. de Wit, Helga E. de Vries +12 morewiley +1 more source
