Results 231 to 240 of about 20,650 (306)

Claudin-Low [PDF]

, 2020
openaire   +1 more source

Host immune collapse in influenza‐associated pulmonary aspergillosis: From barrier dysfunction to metabolic paralysis

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
From barrier dysfunction to metabolic paralysis: IAPA progression is characterized by a functional dissociation: the host experiences hyper‐inflammatory cytokine storms (IL‐1β, IFN‐λ) while simultaneously suffering from antimicrobial metabolic paralysis (loss of ROS and recognition). This creates a specific window for host‐directed therapies, including
Liangyu Li, Shuo Liang
wiley   +1 more source

Effect of heat stress on jejunal epithelial barrier integrity in broilers divergently selected for high- and low-water efficiency. [PDF]

Poult Sci
Greene ES, Orlowski S, Dridi S.
europepmc   +1 more source

The Dual Role of Autophagy in Cancer: Mechanisms and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Autophagy is a conserved cellular process degrading dysfunctional organelles and protein aggregates to maintain cell homeostasis, and it exhibits context‐dependent duality in cancer. Autophagy functions as a critical tumor‐suppressive mechanism by preventing DNA damage and mutation during tumor initiation.
Xiang‐Zheng Gao, Yuheng Qin, Haoyu Wan, Guang Lu, Han‐Ming Shen   +4 more
wiley   +1 more source

Claudin 24-A novel enhancer of AMPA receptor fidelity. [PDF]

Sci Adv
Strasdeit T, Amin E, Obst S, Biermann B, Newton TP, Kösters SC, Schouwink M, Fedotov S, Shaukat J, Bhattacharya S, Aslam M, Anstötz M, Okka FN, Sevillano Quispe OG, Bouvain P, Vedyashkin J, Sobolevsky AI, Traynelis SF, von Engelhardt J, Erlenhardt N, Hollmann M, Klöcker N.   +21 more
europepmc   +1 more source

Colorectal Precancerous Lesions: Molecular Mechanisms, Research Tools, and Natural Product‐Based Clinical Translation

MedComm – Oncology, Volume 5, Issue 2, June 2026.
This article systematically elucidates the molecular mechanisms of colorectal precancerous lesions, introduces cutting‐edge research tools like multi‐omics and organoids, and highlights the potential and prospects of natural products such as berberine, resveratrol, and curcumin in preventing and intervening in colorectal carcinogenesis by modulating ...
Shunji Liu, Chujuan Cui, Lingdong Kong, Qiang Xu, Haibo Cheng, Lisha Zhou, Yang Sun   +6 more
wiley   +1 more source

Claudin and Rab proteins are key molecular components involved in coccidiosis resistance in Portuguese Merino sheep. [PDF]

Genet Sel Evol
Varela-Martínez E, Afonso A, Mainou D, Teixeira F, Nunes T, Vieira P, Sarraguça I, Martins C, Campbell N, da Silva RC, Perloiro T, de Carvalho LM, Ferreira AC, da Gama LT, Waap H, Amaral AJ.   +15 more
europepmc   +1 more source

What practicing pathologists and oncologists should know about the new computational pathology‐based companion diagnostic tools

The Journal of Pathology, Volume 269, Issue 2, Page 143-148, June 2026.
Abstract The integration of artificial intelligence into pathology is transforming the assessment of histological and immunohistochemical (IHC) slides, offering opportunities to reduce variability and streamline diagnostics. In practical terms, most available tools and research models emulate the diagnostic capabilities of pathologists by detecting ...
Diana Montezuma, Sara P. Oliveira, Inti Zlobec, Nadieh Khalili, Jordi Temprana‐Salvador, Sabine Leh, David Ameisen, Mircea‐Sebastian Șerbănescu, Arsela Prelaj, Jakob Nikolas Kather, Norman Zerbe, Vincenzo L'Imperio   +11 more
wiley   +1 more source

AOH induces oxidative stress and DNA damage in ovarian cancer cells via modulation of GPER1 and HIF1α/PI3K/CLDNs signaling pathway. [PDF]

Sci Rep
Kozieł-Leszczyńska MJ, Habrowska-Górczyńska DE, Leszczyński KP, Urbanek KA, Piastowska-Ciesielska AW, Kowalska K.   +5 more
europepmc   +1 more source

Limitations of the refolding pipeline for de novo protein design

Protein Science, Volume 35, Issue 6, June 2026.
Abstract With the emergence of powerful deep learning‐based tools, computational protein design has become a widely accessible technique. Nowadays, it is possible to perform both sequence and structure design in a matter of minutes, making the technology attractive to the broader scientific community. In protein design campaigns, one of the most common
Kerlen T. Korbeld, Vsevolod Viliuga, Maximilian J. L. J. Fürst   +2 more
wiley   +1 more source