miR-222-3p reduces myocardial injury in sepsis by regulating NFATc3. [PDF]
Yang X +5 more
europepmc +1 more source
Regulation of cellular proteostasis via mitochondrial protein import. [PDF]
Nguyen NGT, Li J.
europepmc +1 more source
Mode of action guided metagenomic natural product discovery reveals convergent evolution of a ClpP-targeting motif. [PDF]
Kan J +9 more
europepmc +1 more source
Dachaihu decoction alleviates septic liver injury by modulating the intestinal barrier dysfunction and suppressing the NF-κB/NLRP3/Caspase-1 signaling pathway. [PDF]
Yang Z +8 more
europepmc +1 more source
Clp Chaperone–Proteases: Structure and Function
Clp proteases are the most widespread energy-dependent proteases in bacteria. Their two-component architecture of protease core and ATPase rings results in an inventory of several Clp protease complexes that often coexist. Here, we present insights into Clp protease function, from their assembly to substrate recruitment and processing, and how this is ...
Eilika Weber-Ban +2 more
exaly +8 more sources
The Clp Protease System; A Central Component of the Chloroplast Protease Network
Intra-plastid proteases play crucial and diverse roles in the development and maintenance of non-photosynthetic plastids and chloroplasts. Formation and maintenance of a functional thylakoid electron transport chain requires various protease activities, operating in parallel, as well as in series. This review first provides a short, referenced overview
Jitae Kim +2 more
exaly +3 more sources
Clp Protease and OR Directly Control the Proteostasis of Phytoene Synthase, the Crucial Enzyme for Carotenoid Biosynthesis in Arabidopsis [PDF]
Ajuts: This work was supported by Agriculture and Food Research Initiative competitive award no. 2016-67013-24612 from the USDA National Institute of Food and Agriculture and by the HarvestPlus research consortium (2014H6320.FRE)Phytoene synthase (PSY ...
Manuel Rodriguez-Concepcion +2 more
exaly +2 more sources
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Tagging Proteins for the Clp Protease
Nature Reviews Microbiology, 2016Katharine Wrighton
exaly +2 more sources
Clp-Targeting BacPROTACs Impair Mycobacterial Proteostasis and Survival [PDF]
The ClpC1:ClpP1P2 protease is a core component of the proteostasis system in mycobacteria. To improve the efficacy of antitubercular agents targeting the Clp protease, we characterized the mechanism of the antibiotics cyclomarin A and ecumicin ...
Anton Meinhart, Tim Clausen
exaly +3 more sources

