Results 91 to 100 of about 5,725 (156)

Expression of type II toxin-antitoxin systems and ClpP protease of methicillin-resistant Staphylococcus aureus under thermal and oxidative stress conditions. [PDF]

Iran J Microbiol, 2021
Karimaei S, Kalani BS, Shahrokhi N, Mashhadi R, Pourmand MR.   +4 more
europepmc   +1 more source

Structure-guided development of selective caseinolytic protease P agonists as antistaphylococcal agents

Cell Reports Medicine
Summary: Methicillin-resistant Staphylococcus aureus is a ubiquitous pathogen, posing a serious threat to human health worldwide. Thus, there is a high demand for antibiotics with distinct targets. Caseinolytic protease P (ClpP) is a promising target for
Tao Zhang, Pengyu Wang, Hailing Zhou, Bingyan Wei, Yanling Zhao, Jiahui Li, Min Zhang, Wenjuan Wu, Lefu Lan, Jianhua Gan, Cai-Guang Yang   +10 more
doaj   +1 more source

ONC206 targeting ClpP induces mitochondrial dysfunction and protective autophagy in hepatocellular carcinoma cells

Neoplasia: An International Journal for Oncology Research
Hepatocellular carcinoma (HCC) is the most common form of liver cancer, accounting for approximately 90 % of all cases. ONC201, a member of the imipridone drug family, has shown promising therapeutic potential and a good safety profile in both malignant ...
Jiahao Cao, Fei Cao, Chuanzheng Wang, Zhen Jiao, Yuting You, Xiaomin Wang, Wenxiu Zhao   +6 more
doaj   +1 more source

Ferritin Degradation by Pneumococcal HtrA, RadA and ClpP Serine Proteases : A Probable Way For Releasing and Acquisition Of Iron

Infection and Drug Resistance, 2020
Mozhgan Kheirandish,1 Behrooz Motlagh,2 Davoud Afshar1 1Department of Microbiology and Virology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran; 2Department of Clinical Biochemistry, School of Medicine, Zanjan University of ...
Kheirandish M, Motlagh B, Afshar D
doaj  

Polydatin as a natural ClpP modulator for combating methicillin-resistant Staphylococcus aureus infection

Frontiers in Cellular and Infection Microbiology
IntroductionMethicillin resistant Staphylococcus aureus, MRSA, is a major cause of hospital acquired infections and poses a serious therapeutic challenge because of multidrug resistance and potent virulence.
Ying Qin, Jingjing Yang, Guangming Wang, Luna Yang, Dacheng Wang, Yongxin Luan   +5 more
doaj   +1 more source

Imipridone Anticancer Compounds Ectopically Activate the ClpP Protease and Represent a New Scaffold for Antibiotic Development. [PDF]

Genetics, 2020
Jacques S, van der Sloot AM, C Huard C, Coulombe-Huntington J, Tsao S, Tollis S, Bertomeu T, Culp EJ, Pallant D, Cook MA, Bonneil E, Thibault P, Wright GD, Tyers M.   +13 more
europepmc   +1 more source

ATP-dependent Clp protease proteolytic subunit (clpP) [PDF]

Science-Business eXchange, 2011
openaire   +1 more source

Mechanism of the allosteric activation of the ClpP protease machinery by substrates and active-site inhibitors. [PDF]

Sci Adv, 2019
Felix J, Weinhäupl K, Chipot C, Dehez F, Hessel A, Gauto DF, Morlot C, Abian O, Gutsche I, Velazquez-Campoy A, Schanda P, Fraga H.   +11 more
europepmc   +1 more source

Allosteric control of the bacterial ClpC/ClpP protease and its hijacking by antibacterial peptides. [PDF]

EMBO J
Jenne T, Engelhardt L, Baronaite I, Levy D, Riven I, Malolepszy M, Azinas S, Sych T, Sezgin E, Flemming D, Sinning I, Haran G, Carroni M, Mogk A.   +13 more
europepmc   +1 more source

ClpP protease activation results from the reorganization of the electrostatic interaction networks at the entrance pores. [PDF]

Commun Biol, 2019
Mabanglo MF, Leung E, Vahidi S, Seraphim TV, Eger BT, Bryson S, Bhandari V, Zhou JL, Mao YQ, Rizzolo K, Barghash MM, Goodreid JD, Phanse S, Babu M, Barbosa LRS, Ramos CHI, Batey RA, Kay LE, Pai EF, Houry WA.   +19 more
europepmc   +1 more source