Pharmaceutical Cocrystals in Drug-Delivery Technologies: Advances from Rational Design to Therapeutic Applications [PDF]
PharmaceuticsPharmaceutical cocrystals are a well-established class of solid-state forms that can modulate the solubility, dissolution, stability, and bioavailability of active pharmaceutical ingredients without altering their molecular identity. Although traditional
Marina Monserrat Marcos Valdez +3 more
doaj +2 more sources
Beyond Cocrystals: Hierarchical Functional Assemblies via Noncovalent Synthesis [PDF]
Advanced ScienceCocrystals are solid crystals formed by the combination of multiple components through non‐covalent interactions (NCIs). Despite their diverse structures and tunable optoelectronic properties, they cannot meet the demand for multi‐functionalization of ...
Ya‐Nan Zhu +6 more
doaj +2 more sources
Flavonoid-Based Cocrystals: A Comprehensive Study on Their Synthesis, Characterization, Physicochemical Properties and Applications [PDF]
MoleculesFlavonoids are naturally occurring compounds with reported anticancer, antimicrobial, anti-inflammatory, cardio-protective and antioxidant effects. They are increasingly incorporated in functional foods designed to promote health, enhance well-being, and
Urszula Izabela Maciołek +4 more
doaj +2 more sources
Cocrystallization of Ezetimibe with Organic Acids: Stoichiometric Optimization for Improved Solubility and Bioavailability [PDF]
PharmaceuticsBackground/Objectives: Pharmaceutical cocrystallization offers a promising strategy to enhance drug properties while preserving molecular integrity.
Ravi Maharjan +7 more
doaj +2 more sources
Research note: Dietary curcumin cocrystals enhance egg quality and lipid metabolism in laying hens [PDF]
Poultry ScienceThis study was conducted to evaluate the effects of dietary curcumin cocrystals on laying performance, egg quality, and lipid metabolism in laying hens.
Linglian Kong +4 more
doaj +2 more sources
Solid State Characterization and Dissolution Enhancement of Nevirapine Cocrystals [PDF]
Advanced Pharmaceutical Bulletin, 2021 Purpose: Novel cocrystals of nevirapine (NP) were designed and prepared with salicylamide and 3-hydroxy benzoic acid (3-HBA). Methods: The cocrystals were prepared by solvent drop grinding method by adding few drops of acetone to enhance the solubility ...
Prabhakar Panzade +3 more
doaj +1 more source
Crystals, 2021 Nowadays, many commercial drugs have poor solubility and bioavailability. Cocrystals are formulated to modulate active pharmaceutical ingredients’ properties with improved solubility, dissolution, and bioavailability compared to their pristine individual
Jianbing Tan, Jianhao Liu, Liling Ran
doaj +1 more source
Synthesis and Characterization of Nano-Sized 4-Aminosalicylic Acid–Sulfamethazine Cocrystals
Pharmaceutics, 2021 Drug–drug cocrystals are formulated to produce combined medication, not just to modulate active pharmaceutical ingredient (API) properties. Nano-crystals adjust the pharmacokinetic properties and enhance the dissolution of APIs.
Ala’ Salem +8 more
doaj +1 more source
Organic Cocrystals: Recent Advances and Perspectives for Electronic and Magnetic Applications
Frontiers in Chemistry, 2021 Cocrystal engineering is an advanced supramolecular strategy that has attracted a lot of research interest. Many studies on cocrystals in various application fields have been reported, with a particular focus on the optoelectronics field.
Mengjia Jiang +6 more
doaj +1 more source
Recent advances in improving oral drug bioavailability by cocrystals [PDF]
BioImpacts, 2018 Introduction: Oral drug delivery is the most favored route of drug administration. However, poor oral bioavailability is one of the leading reasons for insufficient clinical efficacy.
Shahram Emami +3 more
doaj +1 more source