Results 11 to 20 of about 16,055 (257)

Cocrystals of Modafinil-Nicotinic Acid: A Novel Cocrystal for Enhanced Bioavailability [PDF]

Proceedings, 2021
In this work, we are the first to identify and report pharmaceutically effective cocrystals of the poorly soluble drug Modafinil (MOD) using a crystal engineering approach.
Tanmoy Ghosh, Thimmasetty Juturu, Shashank Nayak Nagar, Shwetha Kamath   +3 more
doaj   +3 more sources

Mechanosynthesis of Higher‐Order Cocrystals: Tuning Order, Functionality and Size in Cocrystal Design** [PDF]

Angewandte Chemie International Edition, 2021
Abstract The ability to rationally design and predictably construct crystalline solids has been the hallmark of crystal engineering research. To date, numerous examples of multicomponent crystals comprising organic molecules have been reported.
Zi Xuan Ng, Davin Tan, Wei Liang Teo, Félix León, Xiaoyan Shi, Ying Sim, Yongxin Li, Rakesh Ganguly, Yanli Zhao, Sharmarke Mohamed, Felipe Garcı́a   +10 more
openalex   +6 more sources

Recent advances in improving oral drug bioavailability by cocrystals [PDF]

BioImpacts, 2018
Introduction: Oral drug delivery is the most favored route of drug administration. However, poor oral bioavailability is one of the leading reasons for insufficient clinical efficacy.
Shahram Emami, Mohammadreza Siahi-Shadbad, Khosro Adibkia, Mohammad Barzegar-Jalali   +3 more
doaj   +1 more source

Cocrystals of Praziquantel with Phenolic Acids: Discovery, Characterization, and Evaluation

Molecules, 2022
Solvent-assisted grinding (SAG) and solution slow evaporation (SSE) methods are generally used for the preparation of cocrystals. However, even by using the same solvent, active pharmaceutical ingredient (API), and cocrystal coformer (CCF), the ...
Shiying Yang, Qiwen Liu, Weiwen Ji, Qi An, Junke Song, Cheng Xing, Dezhi Yang, Li Zhang, Yang Lu, Guanhua Du   +9 more
doaj   +1 more source

Polymorphism in Carbamazepine Cocrystals [PDF]

Crystal Growth & Design, 2008
Cocrystals of carbamazepine with nicotinamide and saccharin are shown to be polymorphic. Two polymorphs of carbamazepine-nicotinamide (CBZ-NCT) cocrystals and two polymorphs of carbamazepine-saccharin (CBZ-SAC) cocrystals were grown from solution in the presence of polymer heteronuclei. The two CBZ-NCT polymorphs, CBZ-NCT I and a polymer nucleated (PN)
William W, Porter, Sophia C, Elie, Adam J, Matzger   +2 more
openaire   +2 more sources

Cocrystals and Drug–Drug Cocrystals of Anticancer Drugs: A Perception towards Screening Techniques, Preparation, and Enhancement of Drug Properties

Crystals, 2022
The most favored approach for drug administration is the oral route. Several anticancer drugs come under this category and mostly lack solubility and oral bioavailability, which are the most common causes of inadequate clinical efficiency. Enhancing oral
Divya Dhatri Kara, Mahalaxmi Rathnanand
doaj   +1 more source

Effect of Surfactants and Polymers on the Dissolution Behavior of Supersaturable Tecovirimat-4-Hydroxybenzoic Acid Cocrystals

Pharmaceutics, 2021
(1) Background: Pharmaceutical cocrystals have attracted remarkable interest and have been successfully used to enhance the absorption of poorly water-soluble drugs.
Yumiao Feng, Yuanyuan Meng, Fangyun Tan, Lin Lv, Zhiping Li, Yuli Wang, Yang Yang, Wei Gong, Meiyan Yang   +8 more
doaj   +1 more source

Preparation, characterization and evaluation of fenofibrate: benzoic acid cocrystals with enhanced pharmaceutical properties

Future Journal of Pharmaceutical Sciences, 2021
Background Cocrystallization process involved the understanding of interaction at molecular level between two molecules in context to their crystal packing and designing of new solids having improved physicochemical as well as pharmaceutical properties ...
Braham Dutt, Manjusha Choudhary, Vikas Budhwar   +2 more
doaj   +1 more source

Preparation, characterization, and pharmacokinetics of rivaroxaban cocrystals with enhanced in vitro and in vivo properties in beagle dogs

International Journal of Pharmaceutics: X, 2022
Rivaroxaban (RIV) is a direct Factor Xa inhibitor anticoagulant, but the oral bioavailability of RIV is estimated to be only 60% due to its poor solubility. The aim of the present study was to improve the solubility and bioavailability of RIV.
Yuanyuan Meng, Fangyun Tan, Jiaxin Yao, Yanan Cui, Yumiao Feng, Zhiping Li, Yuli Wang, Yang Yang, Wei Gong, Meiyan Yang, Xiaolong Kong, Chunsheng Gao   +11 more
doaj   +1 more source

Solution Cocrystallization: A Scalable Approach for Cocrystal Production

Crystals, 2021
With an increasing interest in cocrystals due to various advantages, demand for large-scale cocrystallization techniques is rising. Solution cocrystallization is a solvent-based approach that utilizes several single-component crystallization concepts as ...
Nitin Pawar, Anindita Saha, Neelesh Nandan, Jose V. Parambil   +3 more
doaj   +1 more source