Creating Cocrystals: A Review of Pharmaceutical Cocrystal Preparation Routes and Applications [PDF]
Crystal Growth & Design, 2018 peer ...
Maryam Karimi-Jafari +3 more
openaire +1 more source
Mechanistic and kinetic insight into spontaneous cocrystallisation of isoniazid and benzoic acid [PDF]
, 2015 Solid-state cocrystallisation is of contemporary interest, because it offers an easy and efficient way to produce cocrystals, which are recognized as prospective pharmaceutical materials.
Fabian, Laszlo +5 more
core +1 more source
Acta Pharmaceutica Sinica B, 2019 Pharmaceutical cocrystals are a promising technology that can be used to improve the solubility of poor aqueous compounds. The objective of this study was to systematically investigate the solubility of myricetin (MYR) cocrystals, including their kinetic
Shuzhen Ren +7 more
doaj +1 more source
Hoogsteen base pairs proximal and distal to echinomycin binding sites on DNA [PDF]
, 1987 Forms of the DNA double helix containing non-Watson-Crick base-pairing have been discovered recently based on x-ray diffraction analysis of quinoxaline antibiotic-oligonucleotide complexes.
Dervan, Peter B., Mendel, David
core +2 more sources
Urea as a Cocrystal Former—Study of 3 Urea Based Pharmaceutical Cocrystals [PDF]
Pharmaceutics, 2021 Cocrystallization is commonly used for its ability to improve the physical properties of APIs, such as solubility, bioavailability, compressibility, etc. The pharmaceutical industry is particularly interested in those cocrystals comprising a GRAS former in connection with the target API.
Fucheng Leng, Koen Robeyns, Tom Leyssens
openaire +4 more sources
Pharmaceutical Cocrystal of Piroxicam: Design, Formulation and Evaluation [PDF]
Advanced Pharmaceutical Bulletin, 2017 Purpose: Cocrystallisation of drug with coformers is a promising approach to alter the solid sate properties of drug substances like solubility and dissolution.
Prabhakar Panzade +3 more
doaj +1 more source
Cocrystal formation by Ionic liquid-assisted grinding: Case study with cocrystals of caffeine [PDF]
, 2018 iquid assisted grinding using imidazolium-based ionic liquids (IL-AG) was found to be effective in isolation of cocrystals and cocrystal polymorphs. Isolation of specific polymorphs of caffeine–citric acid (CAF–CA) and caffeine–glutaric acid (CAF–GLU ...
Meyerson, A. S. +2 more
core +1 more source
The curious case of (caffeine).(benzoic acid): how heteronuclear seeding allowed the formation of an elusive cocrystal [PDF]
, 2013 Cocrystals are modular multicomponent solids with exceptional utility in synthetic chemistry and materials science. A variety of methods exist for the preparation of cocrystals yet, some promising cocrystal phases have proven to be intractable synthetic ...
Bucar, Dejan-Kresimir +8 more
core +1 more source
Uracil Derivatives for Halogen-Bonded Cocrystals [PDF]
International Journal of Molecular Sciences, 2021 Among non-covalent interactions, halogen bonding is emerging as a new powerful tool for supramolecular self-assembly. Here, along with a green and effective method, we report three new halogen-bonded cocrystals containing uracil derivatives and 1,2,4,5-tetrafluoro-3,6-diiodobenzene as X-bond donor coformer.
Mónica Benito +4 more
openaire +4 more sources
A nano-cocrystal strategy to improve the dissolution rate and oral bioavailability of baicalein
Asian Journal of Pharmaceutical Sciences, 2019 Baicalein (BE) is one of the main active flavonoids representing the variety of pharmacological effects including anticancer, anti-inflammatory and cardiovascular protective activities, but it's very low solubility, dissolution rate and poor oral ...
Jiaxin Pi +9 more
doaj +1 more source