Enhanced Dissolution of Naproxen by Combining Cocrystallization and Eutectic Formation
Pharmaceutics, 2021 Improving dissolution properties of active pharmaceutical ingredients (APIs) is a critical step in drug development with the increasing occurrence of sparingly soluble APIs.
Hakyeong Kim, Soeun Jang, Il Won Kim
doaj +1 more source
Process monitoring and visualization solutions for hot-melt extrusion : a review [PDF]
, 2013 Objectives: Hot-melt extrusion (HME) is applied as a continuous pharmaceutical manufacturing process for the production of a variety of dosage forms and formulations.
De Beer, Thomas +3 more
core +2 more sources
Cocrystals of Isoniazid with Polyphenols: Mechanochemical Synthesis and Molecular Structure
Crystals, 2020 Isoniazid is used as anti-tuberculosis drug which possesses functional groups capable of forming hydrogen bonds. A series of cocrystals of isoniazid (INH) with polyphenolic coformers such as catechol (CAT), orcinol (ORC), 2-methylresorcinol (MER ...
Juan Saulo González-González +6 more
doaj +1 more source
Pharmaceutical cocrystals: A review of preparations, physicochemical properties and applications
Acta Pharmaceutica Sinica B, 2021 Pharmaceutical cocrystals are multicomponent systems in which at least one component is an active pharmaceutical ingredient and the others are pharmaceutically acceptable ingredients.
Minshan Guo +3 more
doaj +1 more source
Continuous cocrystallization of benzoic acid and isonicotinamide by mixing-induced supersaturation : exploring opportunities between reactive and antisolvent crystallization concepts [PDF]
, 2017 This study combines reactive and antisolvent crystallization concepts via mixing-induced supersaturation to demonstrate a wider range of options for solvent system selection in multicomponent crystallization.
Connor, Lauren E. +5 more
core +1 more source
Improvement of physicochemical parameters of acyclovir using cocrystallization approach
Brazilian Journal of Pharmaceutical SciencesAcyclovir is an antiviral drug having potent activity against the virus of herpes family and varicella zoster. Unfortunately, drug suffers very poor oral bioavailability (15-30%).
Jignasa Ketan Savjani, Chirag Pathak
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Cocrystal Transition Points: Role of Cocrystal Solubility, Drug Solubility, and Solubilizing Agents [PDF]
Molecular Pharmaceutics, 2015 In this manuscript we bring together concepts that are relevant to the solubilization and thermodynamic stability of cocrystals in the presence of drug solubilizing agents. Simple equations are derived that allow calculation of cocrystal solubilization and transition point solubility.
Maya P, Lipert +1 more
openaire +2 more sources
Preparation and physicochemical characterization of sildenafil cocrystals
Journal of Advanced Pharmaceutical Technology & Research, 2021 Sildenafil is a specific inhibitor of the phosphodiesterase type 5 (PDE-5) enzyme that protects cyclic guanosine monophosphate from breakdown by PDE-5. It is a biopharmaceutical categorization system Class II medication with low bioavailability because ...
Somchai Sawatdee +6 more
doaj +1 more source
Charge Transport in Ternary Charge‐Transfer Solid Solution Single Crystals
Advanced Functional Materials, EarlyView.This study deconvolutes the roles of indirect (superexchange) and direct electronic coupling on charge transport in single crystals of an organic charge‐transfer molecular semiconductor (OSC). This model system elegantly demonstrates that structural defects introduced by chemical dopants play a significant role in the electronic performance ...
Jonathan C. Novak +7 more
wiley +1 more source
Thermally Activated Delayed Fluorescence in Phase‐Separated Nanostructures
Advanced Functional Materials, EarlyView.A supramolecular, phase‐separation driven strategy yields charge transfer (CT) complexes from alternating electron‐deficient pyromellitic diimide and electron‐rich 4,5‐dibromoveratrole. The resulting CT complexes self‐assemble into lamellar nanosheets with nanometer‐sized domains that exhibit thermally activated delayed fluorescence (TADF) at room ...
Bart W.L. van den Bersselaar +8 more
wiley +1 more source