Results 1 to 10 of about 1,577,940 (309)
How plants synthesize coenzyme Q [PDF]
Plant Communications, 2022 Coenzyme Q (CoQ) is a conserved redox-active lipid that has a wide distribution across the domains of life. CoQ plays a key role in the oxidative electron transfer chain and serves as a crucial antioxidant in cellular membranes.
Jing-Jing Xu +3 more
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Biosynthesis, Deficiency, and Supplementation of Coenzyme Q [PDF]
Antioxidants, 2023 Originally identified as a key component of the mitochondrial respiratory chain, Coenzyme Q (CoQ or CoQ10 for human tissues) has recently been revealed to be essential for many different redox processes, not only in the mitochondria, but elsewhere within
Carmine Staiano +6 more
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Understanding coenzyme Q. [PDF]
Physiol RevCoenzyme Q (CoQ), also known as ubiquinone, comprises a benzoquinone head group and a long isoprenoid sidechain. It is thus extremely hydrophobic and resides in membranes.
Wang Y, Lilienfeldt N, Hekimi S.
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Coenzyme Q biochemistry and biosynthesis. [PDF]
Trends Biochem Sci, 2023 Coenzyme Q (CoQ) is a remarkably hydrophobic, redox-active lipid that empowers diverse cellular processes. Although most known for shuttling electrons between mitochondrial electron transport chain (ETC) complexes, the roles for CoQ are far more wide ...
Guerra RM, Pagliarini DJ.
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New Insights on the Uptake and Trafficking of Coenzyme Q [PDF]
Antioxidants, 2023 Coenzyme Q (CoQ) is an essential lipid with many cellular functions, such as electron transport for cellular respiration, antioxidant protection, redox homeostasis, and ferroptosis suppression.
Michael D. Guile +3 more
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Mitochondrial matrix RTN4IP1/OPA10 is an oxidoreductase for coenzyme Q synthesis. [PDF]
Nat Chem Biol, 2023 Targeting proximity-labeling enzymes to specific cellular locations is a viable strategy for profiling subcellular proteomes. Here, we generated transgenic mice (MAX-Tg) expressing a mitochondrial matrix-targeted ascorbate peroxidase.
Park I +17 more
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Coenzyme Q at the Hinge of Health and Metabolic Diseases
Antioxidants, 2021 Coenzyme Q is a unique lipidic molecule highly conserved in evolution and essential to maintaining aerobic metabolism. It is endogenously synthesized in all cells by a very complex pathway involving a group of nuclear genes that share high homology among
Juan Diego Hernández-Camacho +4 more
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Cholesterol mediated ferroptosis suppression reveals essential roles of Coenzyme Q and squalene. [PDF]
Commun Biol, 2023 Cholesterol inhibits ferroptosis via CoQ10 and squalene metabolism and cholesterol diet can protect from hepatotoxicity. Recent findings have shown that fatty acid metabolism is profoundly involved in ferroptosis. However, the role of cholesterol in this
Sun Q +11 more
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Mitochondria regulate intracellular coenzyme Q transport and ferroptotic resistance via STARD7. [PDF]
Nat Cell Biol, 2023 Deshwal et al. show that the protease PARL regulates coenzyme Q (CoQ) via the lipid transfer protein STARD7. Mitochondrial STARD7 ensures CoQ synthesis; cytosolic STARD7 preserves CoQ transport to the membrane, protecting cells against ferroptosis ...
Deshwal S +9 more
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The Ubiquitous and Multifaceted Coenzyme Q [PDF]
AntioxidantsCoenzyme Q10 (CoQ10) is composed of a benzoquinone ring and an isoprenoid side chain attached to carbon 3 of the ring [...]
Luca Tiano, Plácido Navas
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