Combinatorial chemistry in drug discovery. [PDF]
Curr Opin Chem Biol, 2017 Several combinatorial methods have been developed to create focused or diverse chemical libraries with a wide range of linear or macrocyclic chemical molecules: peptides, non-peptide oligomers, peptidomimetics, small-molecules, and natural product-like organic molecules.
Liu R, Li X, Lam KS.
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Protein-Directed Dynamic Combinatorial Chemistry: A Guide to Protein Ligand and Inhibitor Discovery [PDF]
Molecules, 2016 Protein-directed dynamic combinatorial chemistry is an emerging technique for efficient discovery of novel chemical structures for binding to a target protein.
Renjie Huang, Ivanhoe K. H. Leung
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Virtual Combinatorial Chemistry and Pharmacological Screening: A Short Guide to Drug Design. [PDF]
Int J Mol Sci, 2022 Traditionally, drug development involved the individual synthesis and biological evaluation of hundreds to thousands of compounds with the intention of highlighting their biological activity, selectivity, and bioavailability, as well as their low ...
Suay-García B +4 more
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Protein-Templated Dynamic Combinatorial Chemistry: Brief Overview and Experimental Protocol. [PDF]
European J Org Chem, 2019 Dynamic combinatorial chemistry (DCC) is a powerful tool to identify bioactive compounds. This efficient technique allows the target to select its own binders and circumvents the need for synthesis and biochemical evaluation of all individual derivatives.
Hartman AM, Gierse RM, Hirsch AKH.
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Fragment Linking and Optimization of Inhibitors of the Aspartic Protease Endothiapepsin: Fragment-Based Drug Design Facilitated by Dynamic Combinatorial Chemistry. [PDF]
Angew Chem Int Ed Engl, 2016 Fragment‐based drug design (FBDD) affords active compounds for biological targets. While there are numerous reports on FBDD by fragment growing/optimization, fragment linking has rarely been reported.
Mondal M +5 more
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CHIMIA, 2000 In many areas of chemical synthesis, drug discovery, and materials research, combinatorial approaches are becoming more and more important. One of the most serious bottlenecks in this area is the chemical analysis and screening of the products ...
Renato Zenobi
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Structurally divergent dynamic combinatorial chemistry on racemic mixtures [PDF]
Nature Communications, 2020 Structurally divergent reactions on racemic mixtures, which produce distinct chemical species from an enantiomeric mixture, are extremely rare in the literature.
Tiberiu-M. Gianga, G. Dan Pantoș
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Biomimetic selenocystine based dynamic combinatorial chemistry for thiol-disulfide exchange. [PDF]
Nat Commun, 2021 Canal-Martín A, Pérez-Fernández R.
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Nova Biotechnologica et Chimica, 2014 The review will focus on the aspects of combinatorial chemistry and technologies that are more relevant in the modern pharmaceutical process. An historical, critical introduction is followed by three chapters, dealing with the use of combinatorial ...
Seneci Pierfausto +3 more
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Mesofluidic devices for DNA-programmed combinatorial chemistry. [PDF]
PLoS ONE, 2012 Hybrid combinatorial chemistry strategies that use DNA as an information-carrying medium are proving to be powerful tools for molecular discovery. In order to extend these efforts, we present a highly parallel format for DNA-programmed chemical library ...
Rebecca M Weisinger +3 more
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