Results 1 to 10 of about 34,888 (134)
CHIMIA, 2000 In many areas of chemical synthesis, drug discovery, and materials research, combinatorial approaches are becoming more and more important. One of the most serious bottlenecks in this area is the chemical analysis and screening of the products ...
Renato Zenobi
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Structurally divergent dynamic combinatorial chemistry on racemic mixtures [PDF]
Nature Communications, 2020 Structurally divergent reactions on racemic mixtures, which produce distinct chemical species from an enantiomeric mixture, are extremely rare in the literature.
Tiberiu-M. Gianga, G. Dan Pantoș
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Mesofluidic devices for DNA-programmed combinatorial chemistry. [PDF]
PLoS ONE, 2012 Hybrid combinatorial chemistry strategies that use DNA as an information-carrying medium are proving to be powerful tools for molecular discovery. In order to extend these efforts, we present a highly parallel format for DNA-programmed chemical library ...
Rebecca M Weisinger +3 more
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Current Biology, 1998 Abstract The field of combinatorial chemistry was instigated primarily in response to the need for large libraries of novel compounds to feed the high throughput screening facilities developed by biologists. Traditional methods of organic synthesis involving the sequential synthesis of individual molecules are simply orders of magnitude ...
Czarnik, Anthony W, Keene, Jack D
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Protein-Directed Dynamic Combinatorial Chemistry: A Guide to Protein Ligand and Inhibitor Discovery [PDF]
Molecules, 2016 Protein-directed dynamic combinatorial chemistry is an emerging technique for efficient discovery of novel chemical structures for binding to a target protein.
Renjie Huang, Ivanhoe K. H. Leung
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Beilstein Journal of Organic Chemistry, 2021 A base- and catalyst-free C(sp3)–H allylic alkylation of 2-alkylpyridines with Morita–Baylis–Hillman (MBH) carbonates is described. A plausible mechanism of the reaction might involve a tandem SN2’ type nucleophilic substitution followed by an aza-Cope ...
Siyu Wang +5 more
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Microorganisms, 2023 Anthracyclines are an important class of natural antitumor drugs. They have a conservative aromatic tetracycline backbone that is substituted with different deoxyglucoses.
Liyan Yang +5 more
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Nova Biotechnologica et Chimica, 2014 The review will focus on the aspects of combinatorial chemistry and technologies that are more relevant in the modern pharmaceutical process. An historical, critical introduction is followed by three chapters, dealing with the use of combinatorial ...
Seneci Pierfausto +3 more
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Combinatorial Chemistry: A Guide for Librarians.
Issues in Science and Technology Librarianship, 2002 In the 1980s a need to synthesize many chemical compounds rapidly and inexpensively spawned a new branch of chemistry known as combinatorial chemistry.
Philip Barnett
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AlgM4: A New Salt-Activated Alginate Lyase of the PL7 Family with Endolytic Activity
Marine Drugs, 2018 Alginate lyases are a group of enzymes that catalyze the depolymerization of alginates into oligosaccharides or monosaccharides. These enzymes have been widely used for a variety of purposes, such as producing bioactive oligosaccharides, controlling the ...
Guiyuan Huang +7 more
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