Results 1 to 10 of about 1,138,167 (190)
Structurally divergent dynamic combinatorial chemistry on racemic mixtures [PDF]
Nature Communications, 2020 Structurally divergent reactions on racemic mixtures, which produce distinct chemical species from an enantiomeric mixture, are extremely rare in the literature.
Tiberiu-M. Gianga, G. Dan Pantoș
doaj +2 more sources
Nova Biotechnologica et Chimica, 2014 The review will focus on the aspects of combinatorial chemistry and technologies that are more relevant in the modern pharmaceutical process. An historical, critical introduction is followed by three chapters, dealing with the use of combinatorial ...
Seneci Pierfausto +3 more
doaj +2 more sources
Fragment Linking and Optimization of Inhibitors of the Aspartic Protease Endothiapepsin: Fragment‐Based Drug Design Facilitated by Dynamic Combinatorial Chemistry [PDF]
Angewandte Chemie, 2016 Fragment‐based drug design (FBDD) affords active compounds for biological targets. While there are numerous reports on FBDD by fragment growing/optimization, fragment linking has rarely been reported.
M. Mondal +5 more
semanticscholar +2 more sources
Dynamic Combinatorial Libraries: From Exploring Molecular Recognition to Systems Chemistry [PDF]
Journal of the American Chemical Society, 2013 Dynamic combinatorial chemistry (DCC) is a subset of combinatorial chemistry where the library members interconvert continuously by exchanging building blocks with each other.
Li, Jianwei, +2 more
core +3 more sources
CHIMIA, 2000 In many areas of chemical synthesis, drug discovery, and materials research, combinatorial approaches are becoming more and more important. One of the most serious bottlenecks in this area is the chemical analysis and screening of the products ...
Renato Zenobi
doaj +3 more sources
Protein-Directed Dynamic Combinatorial Chemistry: A Guide to Protein Ligand and Inhibitor Discovery
Molecules, 2016 Protein-directed dynamic combinatorial chemistry is an emerging technique for efficient discovery of novel chemical structures for binding to a target protein.
Renjie Huang, Ivanhoe K. H. Leung
doaj +2 more sources
Machine learning in combinatorial polymer chemistry
Nature Reviews Materials, 2021 Adam J Gormley, Michael A Webb
exaly +2 more sources
Dynamic Combinatorial Chemistry [PDF]
Chemical Reviews, 2006 Corbett, Peter T., +6 more
core +2 more sources
Virtual Combinatorial Chemistry and Pharmacological Screening: A Short Guide to Drug Design
International Journal of Molecular Sciences, 2022 Traditionally, drug development involved the individual synthesis and biological evaluation of hundreds to thousands of compounds with the intention of highlighting their biological activity, selectivity, and bioavailability, as well as their low ...
Beatriz Suay-García +4 more
semanticscholar +1 more source
Biomimetic selenocystine based dynamic combinatorial chemistry for thiol-disulfide exchange
Nature Communications, 2021 Dynamic combinatorial chemistry applied to biological environments requires the exchange chemistry of choice to take place under physiological conditions.
Andrea Canal-Martín +1 more
semanticscholar +1 more source