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Dynamic combinatorial chemistry. [PDF]
ChemInform, 2006 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
P. Corbett +6 more
semanticscholar +7 more sources
Combinatorial chemistry in drug discovery. [PDF]
Curr Opin Chem Biol, 2017 Several combinatorial methods have been developed to create focused or diverse chemical libraries with a wide range of linear or macrocyclic chemical molecules: peptides, non-peptide oligomers, peptidomimetics, small-molecules, and natural product-like organic molecules.
Liu R, Li X, Lam KS.
europepmc +8 more sources
Protein-Directed Dynamic Combinatorial Chemistry: A Guide to Protein Ligand and Inhibitor Discovery [PDF]
Molecules, 2016 Protein-directed dynamic combinatorial chemistry is an emerging technique for efficient discovery of novel chemical structures for binding to a target protein.
Renjie Huang, Ivanhoe K. H. Leung
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Virtual Combinatorial Chemistry and Pharmacological Screening: A Short Guide to Drug Design. [PDF]
Int J Mol Sci, 2022 Traditionally, drug development involved the individual synthesis and biological evaluation of hundreds to thousands of compounds with the intention of highlighting their biological activity, selectivity, and bioavailability, as well as their low ...
Suay-García B +4 more
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Biomimetic selenocystine based dynamic combinatorial chemistry for thiol-disulfide exchange. [PDF]
Nat Commun, 2021 Dynamic combinatorial chemistry applied to biological environments requires the exchange chemistry of choice to take place under physiological conditions.
Canal-Martín A, Pérez-Fernández R.
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Protein-Templated Dynamic Combinatorial Chemistry: Brief Overview and Experimental Protocol. [PDF]
European J Org Chem, 2019 Dynamic combinatorial chemistry (DCC) is a powerful tool to identify bioactive compounds. This efficient technique allows the target to select its own binders and circumvents the need for synthesis and biochemical evaluation of all individual derivatives.
Hartman AM, Gierse RM, Hirsch AKH.
europepmc +2 more sources
CHIMIA, 2000 In many areas of chemical synthesis, drug discovery, and materials research, combinatorial approaches are becoming more and more important. One of the most serious bottlenecks in this area is the chemical analysis and screening of the products ...
Renato Zenobi
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Combinatorial Chemistry. By Willi Bannwarth and Eduard Felder [PDF]
Molecules, 2000 n ...
Shu-Kun Lin
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Dynamic Combinatorial Chemistry of Ditellurides. [PDF]
ChemistryAbstractDynamic combinatorial chemistry enables the exploration of reversible chemical exchange reactions. Here, we report studies on the dynamic Te─Te bond exchange of chemically and structurally diverse ditellurides using 125Te NMR spectroscopy. The results revealed rapid and unbiased equilibration, forming a consistent 1:1 distribution of reactants ...
Fisker CD +3 more
europepmc +6 more sources
Nova Biotechnologica et Chimica, 2014 The review will focus on the aspects of combinatorial chemistry and technologies that are more relevant in the modern pharmaceutical process. An historical, critical introduction is followed by three chapters, dealing with the use of combinatorial ...
Seneci Pierfausto +3 more
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