Results 1 to 10 of about 36,550 (274)

Protein-Directed Dynamic Combinatorial Chemistry: A Guide to Protein Ligand and Inhibitor Discovery [PDF]

Molecules, 2016
Protein-directed dynamic combinatorial chemistry is an emerging technique for efficient discovery of novel chemical structures for binding to a target protein.
Renjie Huang, Ivanhoe K. H. Leung
doaj   +4 more sources

Combinatorial Chemistry

CHIMIA, 2000
In many areas of chemical synthesis, drug discovery, and materials research, combinatorial approaches are becoming more and more important. One of the most serious bottlenecks in this area is the chemical analysis and screening of the products ...
Renato Zenobi
doaj   +6 more sources

Structurally divergent dynamic combinatorial chemistry on racemic mixtures [PDF]

Nature Communications, 2020
Structurally divergent reactions on racemic mixtures, which produce distinct chemical species from an enantiomeric mixture, are extremely rare in the literature.
Tiberiu-M. Gianga, G. Dan Pantoș
doaj   +2 more sources

Mesofluidic devices for DNA-programmed combinatorial chemistry. [PDF]

PLoS ONE, 2012
Hybrid combinatorial chemistry strategies that use DNA as an information-carrying medium are proving to be powerful tools for molecular discovery. In order to extend these efforts, we present a highly parallel format for DNA-programmed chemical library ...
Rebecca M Weisinger, Robert J Marinelli, S Jarrett Wrenn, Pehr B Harbury   +3 more
doaj   +2 more sources

Combinatorial Regression for Analytical Chemistry [PDF]

International Journal of Analytical Chemistry
A current problem in analytical chemistry is to match the uncertainty of several independent sample replicates with the measurement uncertainty associated with first-order models.
Jens E. T. Andersen
doaj   +2 more sources

Combinatorial chemistry [PDF]

Current Biology, 1998
Abstract The field of combinatorial chemistry was instigated primarily in response to the need for large libraries of novel compounds to feed the high throughput screening facilities developed by biologists. Traditional methods of organic synthesis involving the sequential synthesis of individual molecules are simply orders of magnitude ...
Czarnik, Anthony W, Keene, Jack D
  +9 more sources

Identification of HuR-RNA Interfering Compounds by Dynamic Combinatorial Chemistry and Fluorescence Polarization. [PDF]

ACS Med Chem Lett, 2023
Volpe SD, Listro R, Ambrosio FA, Garbagnoli M, Linciano P, Rossi D, Costa G, Alcaro S, Vasile F, Hirsch AKH, Collina S.   +10 more
europepmc   +2 more sources

Enzyme-Mediated Dynamic Combinatorial Chemistry Enables Large-Scale Synthesis of δ-Cyclodextrin. [PDF]

J Am Chem Soc
Hansen KH, Erichsen A, Larsen D, Beeren SR.   +3 more
europepmc   +2 more sources

Hit-optimization using target-directed dynamic combinatorial chemistry: development of inhibitors of the anti-infective target 1-deoxy-d-xylulose-5-phosphate synthase. [PDF]

Chem Sci, 2021
Jumde RP, Guardigni M, Gierse RM, Alhayek A, Zhu D, Hamid Z, Johannsen S, Elgaher WAM, Neusens PJ, Nehls C, Haupenthal J, Reiling N, Hirsch AKH.   +12 more
europepmc   +3 more sources

Direct C(sp3)–H allylation of 2-alkylpyridines with Morita–Baylis–Hillman carbonates via a tandem nucleophilic substitution/aza-Cope rearrangement

Beilstein Journal of Organic Chemistry, 2021
A base- and catalyst-free C(sp3)–H allylic alkylation of 2-alkylpyridines with Morita–Baylis–Hillman (MBH) carbonates is described. A plausible mechanism of the reaction might involve a tandem SN2’ type nucleophilic substitution followed by an aza-Cope ...
Siyu Wang, Lianyou Zheng, Shutao Wang, Shulin Ning, Zhuoqi Zhang, Jinbao Xiang   +5 more
doaj   +1 more source