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Structurally divergent dynamic combinatorial chemistry on racemic mixtures [PDF]
Nature Communications, 2020 Structurally divergent reactions on racemic mixtures, which produce distinct chemical species from an enantiomeric mixture, are extremely rare in the literature.
Tiberiu-M. Gianga, G. Dan Pantoș
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Combinatorial Chemistry. By Willi Bannwarth and Eduard Felder [PDF]
Molecules, 2000 n ...
Shu-Kun Lin
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Mesofluidic devices for DNA-programmed combinatorial chemistry. [PDF]
PLoS ONE, 2012 Hybrid combinatorial chemistry strategies that use DNA as an information-carrying medium are proving to be powerful tools for molecular discovery. In order to extend these efforts, we present a highly parallel format for DNA-programmed chemical library ...
Rebecca M Weisinger +3 more
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CHIMIA, 2000 Some new approaches are described for the synthesis of protein epitope mimetics, in particular, mimics of ?-hairpin structures found in antibodies, growth factors, and other proteins involved in macromolecular recognition in Nature. The mimetics
Luyong Jiang +3 more
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Protein-Directed Dynamic Combinatorial Chemistry: A Guide to Protein Ligand and Inhibitor Discovery [PDF]
Molecules, 2016 Protein-directed dynamic combinatorial chemistry is an emerging technique for efficient discovery of novel chemical structures for binding to a target protein.
Renjie Huang, Ivanhoe K. H. Leung
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Beilstein Journal of Organic Chemistry, 2021 A base- and catalyst-free C(sp3)–H allylic alkylation of 2-alkylpyridines with Morita–Baylis–Hillman (MBH) carbonates is described. A plausible mechanism of the reaction might involve a tandem SN2’ type nucleophilic substitution followed by an aza-Cope ...
Siyu Wang +5 more
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Fermionic Quantum Approximate Optimization Algorithm [PDF]
Physical Review Research 5, 023071 (2023), 2023 Quantum computers are expected to accelerate solving combinatorial optimization problems, including algorithms such as Grover adaptive search and quantum approximate optimization algorithm (QAOA). However, many combinatorial optimization problems involve constraints which, when imposed as soft constraints in the cost function, can negatively impact the
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Microorganisms, 2023 Anthracyclines are an important class of natural antitumor drugs. They have a conservative aromatic tetracycline backbone that is substituted with different deoxyglucoses.
Liyan Yang +5 more
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Nova Biotechnologica et Chimica, 2014 The review will focus on the aspects of combinatorial chemistry and technologies that are more relevant in the modern pharmaceutical process. An historical, critical introduction is followed by three chapters, dealing with the use of combinatorial ...
Seneci Pierfausto +3 more
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AlgM4: A New Salt-Activated Alginate Lyase of the PL7 Family with Endolytic Activity
Marine Drugs, 2018 Alginate lyases are a group of enzymes that catalyze the depolymerization of alginates into oligosaccharides or monosaccharides. These enzymes have been widely used for a variety of purposes, such as producing bioactive oligosaccharides, controlling the ...
Guiyuan Huang +7 more
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