Results 1 to 10 of about 1,161,970 (328)
Structurally divergent dynamic combinatorial chemistry on racemic mixtures [PDF]
Nature Communications, 2020 Structurally divergent reactions on racemic mixtures, which produce distinct chemical species from an enantiomeric mixture, are extremely rare in the literature.
Tiberiu-M. Gianga, G. Dan Pantoș
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Protein-Directed Dynamic Combinatorial Chemistry: A Guide to Protein Ligand and Inhibitor Discovery [PDF]
Molecules, 2016 Protein-directed dynamic combinatorial chemistry is an emerging technique for efficient discovery of novel chemical structures for binding to a target protein.
Renjie Huang, Ivanhoe K. H. Leung
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Fragment Linking and Optimization of Inhibitors of the Aspartic Protease Endothiapepsin: Fragment-Based Drug Design Facilitated by Dynamic Combinatorial Chemistry. [PDF]
Angew Chem Int Ed Engl, 2016 Fragment‐based drug design (FBDD) affords active compounds for biological targets. While there are numerous reports on FBDD by fragment growing/optimization, fragment linking has rarely been reported.
Mondal M +5 more
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Nova Biotechnologica et Chimica, 2014 The review will focus on the aspects of combinatorial chemistry and technologies that are more relevant in the modern pharmaceutical process. An historical, critical introduction is followed by three chapters, dealing with the use of combinatorial ...
Seneci Pierfausto +3 more
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Mesofluidic devices for DNA-programmed combinatorial chemistry. [PDF]
PLoS ONE, 2012 Hybrid combinatorial chemistry strategies that use DNA as an information-carrying medium are proving to be powerful tools for molecular discovery. In order to extend these efforts, we present a highly parallel format for DNA-programmed chemical library ...
Rebecca M Weisinger +3 more
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CHIMIA, 2000 In many areas of chemical synthesis, drug discovery, and materials research, combinatorial approaches are becoming more and more important. One of the most serious bottlenecks in this area is the chemical analysis and screening of the products ...
Renato Zenobi
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Generation of a Multicomponent Library of Disulfide Donor-Acceptor Architectures Using Dynamic Combinatorial Chemistry. [PDF]
Int J Mol Sci, 2015 Drożdż W +4 more
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Beilstein Journal of Organic Chemistry, 2021 A base- and catalyst-free C(sp3)–H allylic alkylation of 2-alkylpyridines with Morita–Baylis–Hillman (MBH) carbonates is described. A plausible mechanism of the reaction might involve a tandem SN2’ type nucleophilic substitution followed by an aza-Cope ...
Siyu Wang +5 more
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Microorganisms, 2023 Anthracyclines are an important class of natural antitumor drugs. They have a conservative aromatic tetracycline backbone that is substituted with different deoxyglucoses.
Liyan Yang +5 more
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