Dynamic Combinatorial Libraries: From Exploring Molecular Recognition to Systems Chemistry [PDF]
Journal of the American Chemical Society, 2013 Dynamic combinatorial chemistry (DCC) is a subset of combinatorial chemistry where the library members interconvert continuously by exchanging building blocks with each other.
Li, Jianwei, +2 more
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Virtual Combinatorial Chemistry and Pharmacological Screening: A Short Guide to Drug Design. [PDF]
Int J Mol Sci, 2022 Traditionally, drug development involved the individual synthesis and biological evaluation of hundreds to thousands of compounds with the intention of highlighting their biological activity, selectivity, and bioavailability, as well as their low ...
Suay-García B +4 more
europepmc +2 more sources
Biomimetic selenocystine based dynamic combinatorial chemistry for thiol-disulfide exchange. [PDF]
Nat Commun, 2021 Dynamic combinatorial chemistry applied to biological environments requires the exchange chemistry of choice to take place under physiological conditions.
Canal-Martín A, Pérez-Fernández R.
europepmc +2 more sources
Dynamic Combinatorial Chemistry [PDF]
Chemical Reviews, 2006 Corbett, Peter T., +6 more
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Protein-Templated Dynamic Combinatorial Chemistry: Brief Overview and Experimental Protocol. [PDF]
European J Org Chem, 2019 Dynamic combinatorial chemistry (DCC) is a powerful tool to identify bioactive compounds. This efficient technique allows the target to select its own binders and circumvents the need for synthesis and biochemical evaluation of all individual derivatives.
Hartman AM, Gierse RM, Hirsch AKH.
europepmc +2 more sources
Combinatorial chemistry in drug discovery. [PDF]
Curr Opin Chem Biol, 2017 Liu R, Li X, Lam KS.
europepmc +2 more sources
Live-Cell-Templated Dynamic Combinatorial Chemistry.
Angewandte Chemie, 2020 Dynamic covalent chemistry combines in a single step the screening and synthesis of ligands for biomolecular recognition. To that, a chemical entity is used as template within a dynamic combinatorial library of interconverting species, so that the ...
D. Carbajo +3 more
semanticscholar +1 more source
Identification of a bladder cancer-specific ligand using a combinatorial chemistry approach
Urologic oncology, 2010 Hongyong Zhang +9 more
openalex +2 more sources
Combinatorial Chemistry: A Guide for Librarians.
Issues in Science and Technology Librarianship, 2002 In the 1980s a need to synthesize many chemical compounds rapidly and inexpensively spawned a new branch of chemistry known as combinatorial chemistry.
Philip Barnett
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AlgM4: A New Salt-Activated Alginate Lyase of the PL7 Family with Endolytic Activity
Marine Drugs, 2018 Alginate lyases are a group of enzymes that catalyze the depolymerization of alginates into oligosaccharides or monosaccharides. These enzymes have been widely used for a variety of purposes, such as producing bioactive oligosaccharides, controlling the ...
Guiyuan Huang +7 more
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