Results 11 to 20 of about 1,137,818 (369)
Nova Biotechnologica et Chimica, 2014 The review will focus on the aspects of combinatorial chemistry and technologies that are more relevant in the modern pharmaceutical process. An historical, critical introduction is followed by three chapters, dealing with the use of combinatorial ...
Seneci Pierfausto +3 more
doaj +2 more sources
Dynamic Combinatorial Libraries: From Exploring Molecular Recognition to Systems Chemistry [PDF]
Journal of the American Chemical Society, 2013 Dynamic combinatorial chemistry (DCC) is a subset of combinatorial chemistry where the library members interconvert continuously by exchanging building blocks with each other.
Li, Jianwei, +2 more
core +3 more sources
Virtual Combinatorial Chemistry and Pharmacological Screening: A Short Guide to Drug Design. [PDF]
Int J Mol Sci, 2022 Traditionally, drug development involved the individual synthesis and biological evaluation of hundreds to thousands of compounds with the intention of highlighting their biological activity, selectivity, and bioavailability, as well as their low ...
Suay-García B +4 more
europepmc +2 more sources
Biomimetic selenocystine based dynamic combinatorial chemistry for thiol-disulfide exchange. [PDF]
Nat Commun, 2021 Dynamic combinatorial chemistry applied to biological environments requires the exchange chemistry of choice to take place under physiological conditions.
Canal-Martín A, Pérez-Fernández R.
europepmc +2 more sources
Protein-Templated Dynamic Combinatorial Chemistry: Brief Overview and Experimental Protocol. [PDF]
European J Org Chem, 2019 Dynamic combinatorial chemistry (DCC) is a powerful tool to identify bioactive compounds. This efficient technique allows the target to select its own binders and circumvents the need for synthesis and biochemical evaluation of all individual derivatives.
Hartman AM, Gierse RM, Hirsch AKH.
europepmc +2 more sources
Fragment Linking and Optimization of Inhibitors of the Aspartic Protease Endothiapepsin: Fragment-Based Drug Design Facilitated by Dynamic Combinatorial Chemistry. [PDF]
Angew Chem Int Ed Engl, 2016 Fragment‐based drug design (FBDD) affords active compounds for biological targets. While there are numerous reports on FBDD by fragment growing/optimization, fragment linking has rarely been reported.
Mondal M +5 more
europepmc +2 more sources
From Dynamic Combinatorial Chemistry to in Vivo Evaluation of Reversible and Irreversible Myeloperoxidase Inhibitors. [PDF]
ACS Med Chem Lett, 2017 The implementation of dynamic combinatorial libraries allowed the determination of highly active reversible and irreversible inhibitors of myeloperoxidase (MPO) at the nanomolar level.
Soubhye J +9 more
europepmc +2 more sources
Beilstein Journal of Organic Chemistry, 2021 A base- and catalyst-free C(sp3)–H allylic alkylation of 2-alkylpyridines with Morita–Baylis–Hillman (MBH) carbonates is described. A plausible mechanism of the reaction might involve a tandem SN2’ type nucleophilic substitution followed by an aza-Cope ...
Siyu Wang +5 more
doaj +1 more source
Live-Cell-Templated Dynamic Combinatorial Chemistry.
Angewandte Chemie, 2020 Dynamic covalent chemistry combines in a single step the screening and synthesis of ligands for biomolecular recognition. To that, a chemical entity is used as template within a dynamic combinatorial library of interconverting species, so that the ...
D. Carbajo +3 more
semanticscholar +1 more source