Results 21 to 30 of about 74,124 (282)
Química Nova, 2000 Combinatorial chemistry has emerged as a tool to circumvent a major problem of pharmaceutical industries to discover new lead compounds. A rapid and massive evaluation of a myriad of newly synthesised compounds can be carried out. Combinatorial synthesis
Andrei Leitão +2 more
doaj +1 more source
Spectral clustering of combinatorial fullerene isomers based on their facet graph structure [PDF]
Journal of Mathematical Chemistry, 18 November 2020, 2019 After Curl, Kroto and Smalley were awarded 1996 the Nobel Prize in chemistry, fullerenes have been subject of much research. One part of that research is the prediction of a fullerene's stability using topological descriptors. It was mainly done by considering the distribution of the twelve pentagonal facets on its surface, calculations mostly were ...
arxiv +1 more source
Química Nova, 2001 Combinatorial Chemistry has become a very efficient methodology in drug research. Recent progress in combinatorial synthesis performed both in solid and solution phase have led to a change in the paradigm for the identification and optimization of lead ...
Ricardo L. Araújo Dias +1 more
doaj +1 more source
Diversity and bioactivity of culturable bacteria from Acanthus ebracteatus
Guangxi Zhiwu, 2023 Acanthus ebracteatus is a special kind of rare mangrove plant, possessing great medicinal value. In this paper, in order to study the diversity of endophytic and rhizosphere culturable bacteria in the A.
Zhe LI +6 more
doaj +1 more source
eLife, 2021 ATP-binding cassette (ABC) transporters constitute the largest family of primary active transporters involved in a multitude of physiological processes and human diseases.
Erich Stefan +7 more
doaj +1 more source
High-throughput in-situ characterization and modelling of precipitation kinetics in compositionally graded alloys [PDF]
, 2015 The development of new engineering alloy chemistries is a time consuming and iterative process. A necessary step is characterization of the nano/microstructure to provide a link between the processing and properties of each alloy chemistry considered.
arxiv +1 more source
Combinatorial and Algebraic Enumeration: a survey of the work of Ian P. Goulden and David M. Jackson [PDF]
arXiv, 2022 In this survey we discuss some of the significant contributions of Ian Goulden and David Jackson in the areas of classical enumeration, symmetric functions, factorizations of permutations, and algebraic foundations of quantum field theory. Through their groundbreaking textbook, {\em Combinatorial Enumeration}, and their numerous research papers, both ...
arxiv
The dual nature of TDC – bridging dendritic and T cells in immunity
FEBS Letters, EarlyView.TDC are hematopoietic cells combining dendritic and T cell features. They reach secondary lymphoid organs (SLOs) and peripheral organs (liver and lungs) after FLT3‐dependent development in the bone marrow and maturation in the thymus. TDC are activated and enriched in SLOs upon viral infection, suggesting that they might play unique immune roles, since
Maria Nelli, Mirela Kuka
wiley +1 more source
Synthesis of Novel 2-(Pyridin-2-yl) Pyrimidine Derivatives and Study of Their Anti-Fibrosis Activity
Molecules, 2020 A pyrimidine moiety exhibiting a wide range of pharmacological activities has been employed in the design of privileged structures in medicinal chemistry. To prepare libraries of novel heterocyclic compounds with potential biological activities, a series
Yi-Fei Gu +6 more
doaj +1 more source
FEBS Letters, EarlyView.In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali +3 more
wiley +1 more source