Results 21 to 30 of about 1,152,460 (369)

Ternary resin-bound Dynamic Combinatorial Chemistry. [PDF]

Chem Commun (Camb), 2012
Gromova AV, Ciszewski JM, Miller BL.
europepmc   +2 more sources

Live-Cell-Templated Dynamic Combinatorial Chemistry.

Angewandte Chemie, 2020
Dynamic covalent chemistry combines in a single step the screening and synthesis of ligands for biomolecular recognition. To that, a chemical entity is used as template within a dynamic combinatorial library of interconverting species, so that the ...
D. Carbajo, Yolanda Pérez, J. Bujons, I. Alfonso   +3 more
semanticscholar   +1 more source

Expression and Purification of Glycosyltransferase DnmS from Streptomyces peucetius ATCC 27952 and Study on Catalytic Characterization of Its Reverse Glycosyltransferase Reaction

Microorganisms, 2023
Anthracyclines are an important class of natural antitumor drugs. They have a conservative aromatic tetracycline backbone that is substituted with different deoxyglucoses.
Liyan Yang, Huimin Zhou, Guiguang Chen, Hongliang Li, Dengfeng Yang, Lixia Pan   +5 more
doaj   +1 more source

Combinatorial Chemistry: A Guide for Librarians.

Issues in Science and Technology Librarianship, 2002
In the 1980s a need to synthesize many chemical compounds rapidly and inexpensively spawned a new branch of chemistry known as combinatorial chemistry.
Philip Barnett
doaj   +1 more source

AlgM4: A New Salt-Activated Alginate Lyase of the PL7 Family with Endolytic Activity

Marine Drugs, 2018
Alginate lyases are a group of enzymes that catalyze the depolymerization of alginates into oligosaccharides or monosaccharides. These enzymes have been widely used for a variety of purposes, such as producing bioactive oligosaccharides, controlling the ...
Guiyuan Huang, Qiaozhen Wang, Mingqian Lu, Chao Xu, Fei Li, Rongcan Zhang, Wei Liao, Shushi Huang   +7 more
doaj   +1 more source

Protein Binding Nanoparticles as an Integrated Platform for Cancer Diagnosis and Treatment

Advanced Science, 2022
Smart nanomaterials constitute a new approach toward safer and more effective combined anti‐cancer immunotherapy. In this study, polydopamine‐multiprotein conjugates (DmPCs) that can be used for targeted delivery of multiple proteins to cells, realize ...
Xuemei Wang, Shengbo Li, Siqi Wang, Shuo Zheng, Zhenbing Chen, Heng Song   +5 more
doaj   +1 more source

Dynamic Combinatorial Chemistry: A New Methodology Comes of Age.

Chemistry, 2018
Dynamic combinatorial chemistry (DCC) has repeatedly proven to be an effective approach to generate directed ligand libraries for macromolecular targets.
Priska Frei, Rachel Hevey, B. Ernst
semanticscholar   +1 more source

A rapid screening, “combinatorial-type” survey of the metalloligand chemistry of Pt₂(PPh₃)₄(μ-S)₂ using electrospray mass spectrometry [PDF]

, 2001
Electrospray mass spectrometry is a rapid and powerful technique for a combinatorial-like survey of the chemistry of the metalloligand Pt₂(PPh₃)₄(μ-S)₂, leading to the successful isolation and crystallographic characterisation of the novel protonated ...
Fong, S.W. Audi, Henderson, William, Hor, T.S. Andy, Oliver, Allen G., Rickard, Clifton E.F., Vittal, Jagadese J.   +5 more
core   +2 more sources

Visual and computational analysis of structure-activity relationships in high-throughput screening data [PDF]

, 2001
Novel analytic methods are required to assimilate the large volumes of structural and bioassay data generated by combinatorial chemistry and high-throughput screening programmes in the pharmaceutical and agrochemical industries. This paper reviews recent
Agrafiotis, Agrafiotis, Ahlberg, Ajay, Ajay, Bayada, Bemis, Bernard, Bonabeau, Brown, Calvert, Card, Chen, Chen, Cho, Christianini, Clark, Clark, Cox, Duda, Edwards, Engels, Frimurer, Gao, Garrido, Ghose, Gillet, Gillet, Hand, Hann, Haupts, Hayward, Hertzberg, Izrailev, Jiang, Jones-Hertzog, Kirew, Kobayashi, Kohonen, Ladd, Lee, Lepre, Martin, Mason, Mello, Meyer, Miller, Mitchell, Oprea, Peter Gedeck, Peter Willett, Poroikov, Rhodes, Roberts, Roberts, Ros, Rusinko, Sadowski, Sadowski, Scherf, Sheridan, Shi, Stanton, Su, Teague, Thompson, Tropsha, Tufte, Tufte, Wagener, Walters, Wang, Wedin, Xie, Xu, Zupan   +75 more
core   +1 more source

Multiprotein Dynamic Combinatorial Chemistry: A Strategy for the Simultaneous Discovery of Subfamily-Selective Inhibitors for Nucleic Acid Demethylases FTO and ALKBH3.

Chemistry - An Asian Journal, 2018
Dynamic combinatorial chemistry (DCC) is a powerful supramolecular approach for discovering ligands for biomolecules. To date, most, if not all, biologically templated DCC systems employ only a single biomolecule to direct the self-assembly process.
Mohua Das, Tianming Yang, Jinghua Dong, Fransisca Prasetya, Yiming Xie, Kendra H. Q. Wong, Adeline Cheong, E. Woon   +7 more
semanticscholar   +1 more source