Results 21 to 30 of about 1,161,970 (328)

Dynamic Combinatorial Chemistry: A New Methodology Comes of Age.

Chemistry, 2018
Dynamic combinatorial chemistry (DCC) has repeatedly proven to be an effective approach to generate directed ligand libraries for macromolecular targets.
Priska Frei, Rachel Hevey, B. Ernst
semanticscholar   +1 more source

Protein Binding Nanoparticles as an Integrated Platform for Cancer Diagnosis and Treatment

Advanced Science, 2022
Smart nanomaterials constitute a new approach toward safer and more effective combined anti‐cancer immunotherapy. In this study, polydopamine‐multiprotein conjugates (DmPCs) that can be used for targeted delivery of multiple proteins to cells, realize ...
Xuemei Wang, Shengbo Li, Siqi Wang, Shuo Zheng, Zhenbing Chen, Heng Song   +5 more
doaj   +1 more source

Visual and computational analysis of structure-activity relationships in high-throughput screening data [PDF]

, 2001
Novel analytic methods are required to assimilate the large volumes of structural and bioassay data generated by combinatorial chemistry and high-throughput screening programmes in the pharmaceutical and agrochemical industries. This paper reviews recent
Agrafiotis, Agrafiotis, Ahlberg, Ajay, Ajay, Bayada, Bemis, Bernard, Bonabeau, Brown, Calvert, Card, Chen, Chen, Cho, Christianini, Clark, Clark, Cox, Duda, Edwards, Engels, Frimurer, Gao, Garrido, Ghose, Gillet, Gillet, Hand, Hann, Haupts, Hayward, Hertzberg, Izrailev, Jiang, Jones-Hertzog, Kirew, Kobayashi, Kohonen, Ladd, Lee, Lepre, Martin, Mason, Mello, Meyer, Miller, Mitchell, Oprea, Peter Gedeck, Peter Willett, Poroikov, Rhodes, Roberts, Roberts, Ros, Rusinko, Sadowski, Sadowski, Scherf, Sheridan, Shi, Stanton, Su, Teague, Thompson, Tropsha, Tufte, Tufte, Wagener, Walters, Wang, Wedin, Xie, Xu, Zupan   +75 more
core   +1 more source

A rapid screening, “combinatorial-type” survey of the metalloligand chemistry of Pt₂(PPh₃)₄(μ-S)₂ using electrospray mass spectrometry [PDF]

, 2001
Electrospray mass spectrometry is a rapid and powerful technique for a combinatorial-like survey of the chemistry of the metalloligand Pt₂(PPh₃)₄(μ-S)₂, leading to the successful isolation and crystallographic characterisation of the novel protonated ...
Fong, S.W. Audi, Henderson, William, Hor, T.S. Andy, Oliver, Allen G., Rickard, Clifton E.F., Vittal, Jagadese J.   +5 more
core   +2 more sources

Affinity chromatography in dynamic combinatorial libraries: one-pot amplification and isolation of a strongly binding receptor [PDF]

, 2010
We report the one-pot amplification and isolation of a nanomolar receptor in a multibuilding block aqueous dynamic combinatorial library using a polymer-bound template.
Aldaye, Au-Yeung, Au-Yeung, Au-Yeung, Besenius, Besenius, Brady, Brisig, Bugaut, Bulos, Cancilla, Chung, Corbett, Corbett, Corbett, Corbett, Corbett, Corbett, Corbett, David C. Sherrington, Eliseev, Eliseev, Gareiss, Grote, Hioki, Hochgürtel, Kerckhoffs, Klekota, Klekota, Ladame, Lam, Lehn, Liénard, Ludlow, McNaughton, McNaughton, McNaughton, Nguyen, Otto, Otto, Otto, Otto, Peter A. G. Cormack, Pol Besenius, Pérez-Fernández, R. Frederick Ludlow, Ramström, Ramström, Roberts, Rodriguez-Docampo, Rowan, Rozenman, Sadownik, Saur, Severin, Sijbren Otto, Sreenivasachary, Staab, Tauk, Valade, Vial, West, Williams, Xu   +63 more
core   +2 more sources

Multiprotein Dynamic Combinatorial Chemistry: A Strategy for the Simultaneous Discovery of Subfamily-Selective Inhibitors for Nucleic Acid Demethylases FTO and ALKBH3.

Chemistry - An Asian Journal, 2018
Dynamic combinatorial chemistry (DCC) is a powerful supramolecular approach for discovering ligands for biomolecules. To date, most, if not all, biologically templated DCC systems employ only a single biomolecule to direct the self-assembly process.
Mohua Das, Tianming Yang, Jinghua Dong, Fransisca Prasetya, Yiming Xie, Kendra H. Q. Wong, Adeline Cheong, E. Woon   +7 more
semanticscholar   +1 more source

Development of Advanced Macrosphelides: Potent Anticancer Agents

Molecules, 2015
Synthetic approaches to macrosphelide derivatives, based on medicinal chemistry, are summarized. This review contains conventional medicinal chemistry approaches, combinatorial chemistry, fluorous tagging techniques and affinity chromatography ...
Seung-Mann Paek
doaj   +1 more source

The Lock is the Key: Development of Novel Drugs through Receptor Based Combinatorial Chemistry

Acta Chimica Slovenica, 2017
Modern drug discovery is mainly based on the de novo synthesis of a large number of compounds with a diversity of chemical functionalities. Though the introduction of combinatorial chemistry enabled the preparation of large libraries of compounds from so-
Goran Šinko, Nikola Maraković
doaj   +1 more source

Dithioacetal Exchange: A New Reversible Reaction for Dynamic Combinatorial Chemistry.

Chemistry, 2016
Reversibility of dithioacetal bond formation is reported under acidic mild conditions. Its utility for dynamic combinatorial chemistry was explored by combining it with orthogonal disulfide exchange.
Andrea M. Escalante, R. Furlan
semanticscholar   +1 more source

Combinatorial structures to modeling simple games and applications [PDF]

, 2017
We connect three different topics: combinatorial structures, game theory and chemistry. In particular, we establish the bases to represent some simple games, defined as influence games, and molecules, defined from atoms, by using combinatorial structures.
Molinero Albareda, Xavier
core   +1 more source