Results 21 to 30 of about 1,064,825 (236)
Combinatorial Chemistry: A Guide for Librarians.
Issues in Science and Technology Librarianship, 2002 In the 1980s a need to synthesize many chemical compounds rapidly and inexpensively spawned a new branch of chemistry known as combinatorial chemistry.
Philip Barnett
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AlgM4: A New Salt-Activated Alginate Lyase of the PL7 Family with Endolytic Activity
Marine Drugs, 2018 Alginate lyases are a group of enzymes that catalyze the depolymerization of alginates into oligosaccharides or monosaccharides. These enzymes have been widely used for a variety of purposes, such as producing bioactive oligosaccharides, controlling the ...
Guiyuan Huang +7 more
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Dynamic Combinatorial Chemistry: A New Methodology Comes of Age.
Chemistry, 2018 Dynamic combinatorial chemistry (DCC) has repeatedly proven to be an effective approach to generate directed ligand libraries for macromolecular targets.
Priska Frei, Rachel Hevey, B. Ernst
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Protein Binding Nanoparticles as an Integrated Platform for Cancer Diagnosis and Treatment
Advanced Science, 2022 Smart nanomaterials constitute a new approach toward safer and more effective combined anti‐cancer immunotherapy. In this study, polydopamine‐multiprotein conjugates (DmPCs) that can be used for targeted delivery of multiple proteins to cells, realize ...
Xuemei Wang +5 more
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Chemistry - An Asian Journal, 2018 Dynamic combinatorial chemistry (DCC) is a powerful supramolecular approach for discovering ligands for biomolecules. To date, most, if not all, biologically templated DCC systems employ only a single biomolecule to direct the self-assembly process.
Mohua Das +7 more
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Development of Advanced Macrosphelides: Potent Anticancer Agents
Molecules, 2015 Synthetic approaches to macrosphelide derivatives, based on medicinal chemistry, are summarized. This review contains conventional medicinal chemistry approaches, combinatorial chemistry, fluorous tagging techniques and affinity chromatography ...
Seung-Mann Paek
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The Lock is the Key: Development of Novel Drugs through Receptor Based Combinatorial Chemistry
Acta Chimica Slovenica, 2017 Modern drug discovery is mainly based on the de novo synthesis of a large number of compounds with a diversity of chemical functionalities. Though the introduction of combinatorial chemistry enabled the preparation of large libraries of compounds from so-
Goran Šinko, Nikola Maraković
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Dithioacetal Exchange: A New Reversible Reaction for Dynamic Combinatorial Chemistry.
Chemistry, 2016 Reversibility of dithioacetal bond formation is reported under acidic mild conditions. Its utility for dynamic combinatorial chemistry was explored by combining it with orthogonal disulfide exchange.
Andrea M. Escalante, R. Furlan
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Nature Nanotechnology, 2007 This chapter focuses on solid-phase (SP) combinatorial chemistry and libraries, and on their most recent applications in the drug discovery process. The first section provides a short history of combinatorial chemistry, and examines the most relevant trends which appeared recently.
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Encoded combinatorial chemistry. [PDF]
Proceedings of the National Academy of Sciences, 1992 The diversity of chemical synthesis and the power of genetics are linked to provide a powerful, versatile method for drug screening. A process of alternating parallel combinatorial synthesis is used to encode individual members of a large library of chemicals with unique nucleotide sequences.
Sydney Brenner, Richard A. Lerner
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