Results 41 to 50 of about 152,959 (357)
Combinatorial chemistry in cancer research [PDF]
Clinical and Translational Oncology, 2007 Among the different strategies to treat cancer, chemotherapy approaches are the subject of intense research efforts. There is still a high demand for new anticancer drugs exhibiting improved efficiency and selectivity for their use in combined therapy strategies.
Messeguer Peypoch, Ángel +1 more
openaire +3 more sources
Discovery of the cryptic function of terpene cyclases as aromatic prenyltransferases
Nature Communications, 2020 Terpene cyclases catalyze the formation of diverse hydrocarbon scaffolds found in terpenoids. Here, the authors report the cryptic function of class I terpene cyclases as aromatic prenyltransferases and the universality of this cryptic feature is ...
Haibing He +12 more
doaj +1 more source
Combinatorial structures to construct simple games and molecules [PDF]
, 2017 We connect three different topics: combinatorial structures, game theory and chemistry. In particular, we establish the bases to represent some simple games, defined as influence games, and molecules, defined from atoms, by using ...
Molinero Albareda, Xavier
core +2 more sources
Combinatorial BLAS 2.0: Scaling combinatorial algorithms on distributed-memory systems [PDF]
arXiv, 2021 Combinatorial algorithms such as those that arise in graph analysis, modeling of discrete systems, bioinformatics, and chemistry, are often hard to parallelize. The Combinatorial BLAS library implements key computational primitives for rapid development of combinatorial algorithms in distributed-memory systems.
arxiv
Química Nova, 2000 Combinatorial chemistry has emerged as a tool to circumvent a major problem of pharmaceutical industries to discover new lead compounds. A rapid and massive evaluation of a myriad of newly synthesised compounds can be carried out. Combinatorial synthesis
Andrei Leitão +2 more
doaj +1 more source
Spectral clustering of combinatorial fullerene isomers based on their facet graph structure [PDF]
Journal of Mathematical Chemistry, 18 November 2020, 2019 After Curl, Kroto and Smalley were awarded 1996 the Nobel Prize in chemistry, fullerenes have been subject of much research. One part of that research is the prediction of a fullerene's stability using topological descriptors. It was mainly done by considering the distribution of the twelve pentagonal facets on its surface, calculations mostly were ...
arxiv +1 more source
Missing Elements and Missing Premises: A Combinatorial Argument for the Ontological Reduction of Chemistry [PDF]
, 2005 Does chemistry reduce to physics? If this means Can we derive the laws of chemistry from the laws of physics?', recent discussions suggest that the answer is no'.
Le Poidevin, R.
core +1 more source
Química Nova, 2001 Combinatorial Chemistry has become a very efficient methodology in drug research. Recent progress in combinatorial synthesis performed both in solid and solution phase have led to a change in the paradigm for the identification and optimization of lead ...
Ricardo L. Araújo Dias +1 more
doaj +1 more source
eLife, 2021 ATP-binding cassette (ABC) transporters constitute the largest family of primary active transporters involved in a multitude of physiological processes and human diseases.
Erich Stefan +7 more
doaj +1 more source