Results 41 to 50 of about 34,541 (197)

Solid-Phase Synthesis of Arylpiperazine Derivatives and Implementation of the Distributed Drug Discovery (D3) Project in the Search for CNS Agents

Molecules, 2011
We have successfully implemented the concept of Distributed Drug Discovery (D3) in the search for CNS agents. Herein, we demonstrate, for the first time, student engagement from different sites around the globe in the development of new biologically ...
William L. Scott, Ziniu Zhou, Martin J. O’Donnell, Grzegorz Satała, Andrzej J. Bojarski, Jean Martinez, Gaël Nomezine, Maciej Pawłowski, Gilles Subra, Katarzyna Grychowska, Joanna Król, Paweł Zajdel   +11 more
doaj   +1 more source

Rapid Discovery of Illuminating Peptides for Instant Detection of Opioids in Blood and Body Fluids

Molecules, 2019
The United States is currently experiencing an opioid crisis, with more than 47,000 deaths in 2017 due to opioid overdoses. Current approaches for opioid identification and quantification in body fluids include immunoassays and chromatographic methods (e.
Shabnam Jafari, Yann Thillier, Yousif H. Ajena, Diedra Shorty, Jiannan Li, Jonathan S. Huynh, Bethany Ming-Choi Pan, Tingrui Pan, Kit S. Lam, Ruiwu Liu   +9 more
doaj   +1 more source

Solid-Phase Synthetic Route to Multiple Derivatives of a Fundamental Peptide Unit

Molecules, 2010
Amino acids are Nature’s combinatorial building blocks. When substituted on both the amino and carboxyl sides they become the basic scaffold present in all peptides and proteins.
Martin J. O’Donnell, Maciej Pawłowski, Ziniu Zhou, Paweł Zajdel, William L. Scott   +4 more
doaj   +1 more source

Identification of Bis-Cyclic Guanidines as Antiplasmodial Compounds from Positional Scanning Mixture-Based Libraries

Molecules, 2019
The screening of more than 30 million compounds derived from 81 small molecule libraries built on 81 distinct scaffolds identified pyrrolidine bis-cyclic guanidine library (TPI-1955) to be one of the most active and selective antiplasmodial libraries ...
David L. Perry, Bracken F. Roberts, Ginamarie Debevec, Heather A. Michaels, Debopam Chakrabarti, Adel Nefzi   +5 more
doaj   +1 more source

Heterologous Expression and Biochemical Characterization of a Novel Lytic Polysaccharide Monooxygenase from Chitinilyticum aquatile CSC-1

Microorganisms
Lytic polysaccharide monooxygenases (LPMOs) are copper-dependent enzymes that catalyze the oxidative cleavage of recalcitrant polysaccharides. There are limited reports on LPMOs capable of concurrently catalyzing the oxidative cleavage of both cellulose ...
Xuezhi Shao, Hongliang Fang, Tao Li, Liyan Yang, Dengfeng Yang, Lixia Pan   +5 more
doaj   +1 more source

Library Design

CHIMIA, 2003
This review aims at giving a short introduction to the most important areas of library design. The description of compounds by descriptors and fingerprints, and similarity-based clustering techniques are illustrated in the context of untargeted ...
Friederike Stoll
doaj   +1 more source

Natural product-like combinatorial libraries

Journal of the Brazilian Chemical Society, 2003
Combinatorial chemistry has emerged over the last few years as an important tool for drug discovery and lead optimisation. In this approach, the molecular diversity and range of biological properties displayed by secondary metabolites constitutes a ...
Abreu Pedro M., Branco Paula S.
doaj  

Strategy and Tactics in Combinatorial Organic Synthesis. Applications to Drug Discovery

CHIMIA, 1997
A strategic analysis of various issues which pertain to the enablement of combinatorial organic synthesis to produce libraries of non-polymeric organic molecules is given.
Eric M. Gordon, Dinesh V. Patel, Jeffrey W. Jacobs, Mikhail F. Gordeev, Joseph Zhou   +4 more
doaj   +2 more sources

Combinatorial Computational Chemistry

Hyomen Kagaku, 2004
A new methodology “Combinatorial Computational Chemistry” was proposed to realize theoretical high-throughput screening of materials. In this review, we introduced our recent successful applications of combinatorial computational chemistry to material design.
Akira Miyamoto, Michihisa Koyama, Momoji Kubo   +2 more
openaire   +3 more sources

Combinatorial Chemistry in Ethnopharmacology [PDF]

Modern Chemistry & Applications, 2013
Biodiversity of natural products supplies an enormous source of drug discovery leads. It is the general belief that the nature of natural products are highly likely to provide therapeutic hits, because there are a greater number of stereocentres that intensifies scaffold diversity as supplied by the organic structures of more fused, bridged and ...
openaire   +2 more sources