Results 61 to 70 of about 72,499 (281)

The [2Fe‐2S] cluster of mitochondrial outer membrane protein mitoNEET has an O2‐regulated nitric oxide access tunnel

FEBS Letters, Volume 599, Issue 7, Page 952-970, April 2025.
The mitochondrial outer membrane iron–sulphur ([Fe‐S]) protein mitoNEET is a target of the type‐2 diabetes drug pioglitazone. Its unknown molecular function is linked to respiratory complex activity and mitochondrial function. We discovered that O2 protects the mitoNEET [2Fe‐2S] cluster against NO oxidation and desensitization towards reduction by H2S.
Thao Nghi Hoang, Meritxell Wu‐Lu, Alberto Collauto, Peter‐Leon Hagedoorn, Madalina Alexandru, Maike Henschel, Shahram Kordasti, Maria Andrea Mroginski, Maxie M. Roessler, Kourosh H. Ebrahimi   +9 more
wiley   +1 more source

A Comparison Of Two Methods For Random Labelling of Balls by Vectors of Integers [PDF]

Advances in Combinatorial Methods and Applications to Statistics, N. Balakrishnan, ed., Birkhauser, 1997 (Mohanty Festschrift], 1998
A combinatorial problem that came up in Combinatorial Chemistry is solved.
arxiv  

Identification of Bis-Cyclic Guanidines as Antiplasmodial Compounds from Positional Scanning Mixture-Based Libraries

Molecules, 2019
The screening of more than 30 million compounds derived from 81 small molecule libraries built on 81 distinct scaffolds identified pyrrolidine bis-cyclic guanidine library (TPI-1955) to be one of the most active and selective antiplasmodial libraries ...
David L. Perry, Bracken F. Roberts, Ginamarie Debevec, Heather A. Michaels, Debopam Chakrabarti, Adel Nefzi   +5 more
doaj   +1 more source

Molecular insights into the modulation of the 5HT2A receptor by serotonin, psilocin, and the G protein subunit Gqα

FEBS Letters, Volume 599, Issue 6, Page 876-891, March 2025.
We explore 5HT2A receptor activation, a key target for psychedelic drugs, using molecular dynamics simulations. Without Gqα, the active receptor collapses to an inactive conformation, underscoring the G‐protein's role. Discovery of an intermediate “partially‐open” state and the higher affinity of ligands to the orthosteric binding site provides ...
Niklas Viohl, Ali Asghar Hakami Zanjani, Himanshu Khandelia   +2 more
wiley   +1 more source

A histidine‐rich extension of the mitochondrial F0 subunit ATP6 from the ice worm Mesenchytraeus solifugus increases ATP synthase activity in bacteria

FEBS Letters, Volume 599, Issue 8, Page 1113-1121, April 2025.
The glacier ice worm Mesenchytraeus solifugus survives year‐round at 0 °C. Its ATP6 subunit, which forms a regulatory component of the proton pore in mitochondrial ATP synthase, has a carboxy‐terminal extension not found in any other organism examined to date. Here, we show that fusion of this extension to the homologous AtpB protein in E. coli results
Truman Dunkley, Daniel H. Shain, Eric A. Klein   +2 more
wiley   +1 more source

Solid-Phase Synthetic Route to Multiple Derivatives of a Fundamental Peptide Unit

Molecules, 2010
Amino acids are Nature’s combinatorial building blocks. When substituted on both the amino and carboxyl sides they become the basic scaffold present in all peptides and proteins.
Martin J. O’Donnell, Maciej Pawłowski, Ziniu Zhou, Paweł Zajdel, William L. Scott   +4 more
doaj   +1 more source

Interaction between bacterial phytochromes Agp1 and Agp2 of Agrobacterium fabrum by fluorescence resonance energy transfer and docking studies

FEBS Letters, Volume 599, Issue 6, Page 848-865, March 2025.
The interaction between Agrobacterium fabrum phytochromes Agp1 and Agp2 was studied using FRET. Full‐length and truncated proteins with varied label positions provided spatial insights, narrowing down from many docking models to three. These models explain Agp2's reduction in Agp1 autophosphorylation, with Arg83 of Agp2 specifically evolved to interact
Afaf El Kurdi, Gero Kaeser, Patrick Scheerer, David Hoffmann, Ebru Akkus, Marcus Elstner, Norbert Krauß, Tilman Lamparter   +7 more
wiley   +1 more source

Solid-Phase Synthesis of Arylpiperazine Derivatives and Implementation of the Distributed Drug Discovery (D3) Project in the Search for CNS Agents

Molecules, 2011
We have successfully implemented the concept of Distributed Drug Discovery (D3) in the search for CNS agents. Herein, we demonstrate, for the first time, student engagement from different sites around the globe in the development of new biologically ...
William L. Scott, Ziniu Zhou, Martin J. O’Donnell, Grzegorz Satała, Andrzej J. Bojarski, Jean Martinez, Gaël Nomezine, Maciej Pawłowski, Gilles Subra, Katarzyna Grychowska, Joanna Król, Paweł Zajdel   +11 more
doaj   +1 more source

Functional variation among LPMOs revealed by the inhibitory effects of cyanide and buffer ions

FEBS Letters, Volume 599, Issue 9, Page 1317-1336, May 2025.
This study addresses the inhibition of lytic polysaccharide monooxygenases (LPMOs) by cyanide and explains how and why the magnitude of observed inhibitory effects depends on the way LPMO reactions are setup and on the type of LPMO. Enzymes known as lytic polysaccharide monooxygenases (LPMOs) are mono‐copper polysaccharide‐degrading peroxygenases that ...
Ole Golten, Lorenz Schwaiger, Zarah Forsberg, Kelsi R. Hall, Anton A. Stepnov, Tom Z. Emrich‐Mills, Iván Ayuso‐Fernández, Morten Sørlie, Roland Ludwig, Åsmund Kjendseth Røhr, Vincent G. H. Eijsink   +10 more
wiley   +1 more source

Solving Quantum Chemistry Problems with a D-Wave Quantum Annealer [PDF]

arXiv, 2018
Quantum annealing devices have been subject to various analyses in order to classify their usefulness for practical applications. While it has been successfully proven that such systems can in general be used for solving combinatorial optimization problems, they have not been used to solve chemistry applications.
arxiv