Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
TOWARDS A MORE EFFECTIVE ENGAGEMENT OF LEARNERS AND TUTORS IN ONLINE DISCUSSION FORUMS [PDF]
Online discussion forums have the potential to add value to the total learning environmental in open distance learning. A study analyzing more than a hundred online forums from twenty offered by four faculties was conducted at the Open University ...
Zoraini Wati Abas, Mansor Fadzil
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Leadership Development for Community Action: An Ethnographic Inquiry: Northwest Federation of Community Organizations [PDF]
LeeAnn Hall directs the Northwest Federation of Community Organizations (NWFCO), a collaboration of four state-based community organizations engaged in the fight for social and economic justice. Leadership development is at the heart of the NWFCO mission
Lisa Weinberg
core
Developing the language of thinking within a classroom community of inquiry: pre-service teachers’ experiences [PDF]
We argue that the “community of inquiry” approach, using reading materials modelled on Lipman’s Philosophy for Children programme, is a theoretically justified and teacher-friendly means of promoting effective thinking skills.
Chigona, Agnes +2 more
core +4 more sources
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
An Item Response Theory Analysis of the Community of Inquiry Scale
The aim of this study is to examine validity and reliability of Community of Inquiry Scale commonly used in online learning by the means of Item Response Theory.
Mehmet Barış Horzum +1 more
doaj
Cooperation and Competition in the Philosothon
Philosothons are events in which students practise Community of Philosophical Inquiry, usually with awards being made using three criteria: critical thinking, creative thinking and collaboration. This seems to generate a tension.
Alan Tapper, Matthew Wills
doaj
Teaching to Connect: Community-Building Strategies for the Virtual Classroom
A sense of community is central to student engagement and satisfaction. However, many students struggle with developing connections in online programs.
Sharla Berry
doaj +1 more source
A design-based study of Citizen Inquiry for geology [PDF]
Citizen Inquiry forms a new method of informal science learning and aims to enable the engagement of citizens in online scientific investigations. Citizen Inquiry combines aspects from Citizen Science and Inquiry-based learning and is implemented through
Aristeidou, Maria +2 more
core +1 more source

