Results 41 to 50 of about 1,203,521 (299)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

TOWARDS A MORE EFFECTIVE ENGAGEMENT OF LEARNERS AND TUTORS IN ONLINE DISCUSSION FORUMS [PDF]

open access: yesAAOU Journal, 2009
Online discussion forums have the potential to add value to the total learning environmental in open distance learning. A study analyzing more than a hundred online forums from twenty offered by four faculties was conducted at the Open University ...
Zoraini Wati Abas, Mansor Fadzil
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Leadership Development for Community Action: An Ethnographic Inquiry: Northwest Federation of Community Organizations [PDF]

open access: yes, 2005
LeeAnn Hall directs the Northwest Federation of Community Organizations (NWFCO), a collaboration of four state-based community organizations engaged in the fight for social and economic justice. Leadership development is at the heart of the NWFCO mission
Lisa Weinberg
core  

Developing the language of thinking within a classroom community of inquiry: pre-service teachers’ experiences [PDF]

open access: yes, 2012
We argue that the “community of inquiry” approach, using reading materials modelled on Lipman’s Philosophy for Children programme, is a theoretically justified and teacher-friendly means of promoting effective thinking skills.
Chigona, Agnes   +2 more
core   +4 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

An Item Response Theory Analysis of the Community of Inquiry Scale

open access: yesInternational Review of Research in Open and Distributed Learning, 2015
The aim of this study is to examine validity and reliability of Community of Inquiry Scale commonly used in online learning by the means of Item Response Theory.
Mehmet Barış Horzum   +1 more
doaj  

Cooperation and Competition in the Philosothon

open access: yesJournal of Philosophy in Schools, 2022
Philosothons are events in which students practise Community of Philosophical Inquiry, usually with awards being made using three criteria: critical thinking, creative thinking and collaboration. This seems to generate a tension.
Alan Tapper, Matthew Wills
doaj  

Teaching to Connect: Community-Building Strategies for the Virtual Classroom

open access: yesOnline Learning, 2019
A sense of community is central to student engagement and satisfaction. However, many students struggle with developing connections in online programs.
Sharla Berry
doaj   +1 more source

A design-based study of Citizen Inquiry for geology [PDF]

open access: yes, 2013
Citizen Inquiry forms a new method of informal science learning and aims to enable the engagement of citizens in online scientific investigations. Citizen Inquiry combines aspects from Citizen Science and Inquiry-based learning and is implemented through
Aristeidou, Maria   +2 more
core   +1 more source

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